OSB3_DICDI
ID OSB3_DICDI Reviewed; 372 AA.
AC Q55CR2;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Oxysterol-binding protein 3;
DE AltName: Full=OSBPc;
GN Name=osbC; ORFNames=DDB_G0269940;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72320.1; -; Genomic_DNA.
DR RefSeq; XP_646419.1; XM_641327.1.
DR AlphaFoldDB; Q55CR2; -.
DR SMR; Q55CR2; -.
DR PaxDb; Q55CR2; -.
DR EnsemblProtists; EAL72320; EAL72320; DDB_G0269940.
DR GeneID; 8617376; -.
DR KEGG; ddi:DDB_G0269940; -.
DR dictyBase; DDB_G0269940; osbC.
DR eggNOG; KOG2210; Eukaryota.
DR HOGENOM; CLU_706815_0_0_1; -.
DR InParanoid; Q55CR2; -.
DR PhylomeDB; Q55CR2; -.
DR Reactome; R-DDI-1482801; Acyl chain remodelling of PS.
DR Reactome; R-DDI-192105; Synthesis of bile acids and bile salts.
DR Reactome; R-DDI-9013407; RHOH GTPase cycle.
DR PRO; PR:Q55CR2; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR PANTHER; PTHR10972; PTHR10972; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR SUPFAM; SSF144000; SSF144000; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..372
FT /note="Oxysterol-binding protein 3"
FT /id="PRO_0000328467"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 372 AA; 42025 MW; 1B75F7065C224202 CRC64;
MGKSDRKLTE ENSIENGVKP GKLTEEEMDA IDNSSQSKIV AIASMAKRLG LGLGSDLSQV
EYPSSFIAPF STLNFFSNNF ANHFNILLRA NKIENEMDRL IEVFKYSTTI HKIPEDCMKV
PLNAVIGETQ SLNFQTPDLN SPNDLISDNY LITEQVSELP PNTATCIYNK KEGVKALFNH
ESKIVFQITN VKTPTTGRKY VRFDKFDEEY DIEFPVLHSR FMRGFVEYCG EGSIKSNKSK
CFVSTNYIAK PLIGGNYHAY EAKVYNGIDS KPIYKISGQW DGESKITNLK TNETKPFFKN
ITTTTNFTPT ILNTDSSVVW GKIIQSVAQG KPINLAREKS KIIENQKTLN WAPSQFFLNL
EMGVWEPKLL ND
