ID   OSB4_DICDI              Reviewed;         466 AA.
AC   Q86KG4; Q559J7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Oxysterol-binding protein 4;
DE   AltName: Full=OSBPd;
GN   Name=osbD; ORFNames=DDB_G0272498;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
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DR   EMBL; AAFI02000008; EAL71173.1; -; Genomic_DNA.
DR   RefSeq; XP_645109.1; XM_640017.1.
DR   AlphaFoldDB; Q86KG4; -.
DR   SMR; Q86KG4; -.
DR   STRING; 44689.DDB0237808; -.
DR   PaxDb; Q86KG4; -.
DR   EnsemblProtists; EAL71173; EAL71173; DDB_G0272498.
DR   GeneID; 8618503; -.
DR   KEGG; ddi:DDB_G0272498; -.
DR   dictyBase; DDB_G0272498; osbD.
DR   eggNOG; KOG2210; Eukaryota.
DR   HOGENOM; CLU_012334_1_0_1; -.
DR   InParanoid; Q86KG4; -.
DR   OMA; SSYWTEH; -.
DR   PhylomeDB; Q86KG4; -.
DR   Reactome; R-DDI-1482801; Acyl chain remodelling of PS.
DR   Reactome; R-DDI-192105; Synthesis of bile acids and bile salts.
DR   Reactome; R-DDI-9013407; RHOH GTPase cycle.
DR   PRO; PR:Q86KG4; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   PANTHER; PTHR10972; PTHR10972; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   SUPFAM; SSF144000; SSF144000; 1.
DR   PROSITE; PS01013; OSBP; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..466
FT                   /note="Oxysterol-binding protein 4"
FT                   /id="PRO_0000328470"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   466 AA;  52915 MW;  4D915AD7E3EC50B3 CRC64;
     MEIGTSSTTN NIGVAPTIPQ DIVNNNNHNN NSSNNSSNNN SISSSPTDSS QLMNGEQSTS
     PPSPPIEEVL EEEPRNLLIS LLSELKIGVD LSRVPLPTFI LEPRSLLEKF TDNMIHGEIL
     CNLSKLESPM DRMHLITKWY LSAFHYRKKG LQKPYNPILG EIFRTRWEFK ETNSNCIMVA
     EQISHHPPVS CIYLSNRKDG YTMTGTINPR SKFLGNSMAV IVDGSSTLTL LGLQEEYVIT
     FPTAVARGII FGTLLTEIVG NSTISCKQTN IKVEMDFKAK PMFGGEYNVV CGKIKKGNET
     THTFNGKWDK KVEITLSSSS SSSKKKNGST NDILWDCNDA VKTQMITRQI SEQEEFESQR
     LWQKVSHAII KKNQKDATFE KNKLEDEQRK RVKDRKENNI EWEPRLFKKV NDQWIYKYQN
     HTLYDQNEPK EIETDGIIHF EGTLIKKESK QNLVEKCGAS ENEIIV