ID   OSB5_DICDI              Reviewed;         362 AA.
AC   Q86HL8; Q555I5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Oxysterol-binding protein 5;
DE            Short=OSBPe;
GN   Name=osbE; ORFNames=DDB_G0274517;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
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DR   EMBL; AAFI02000012; EAL70151.1; -; Genomic_DNA.
DR   RefSeq; XP_644084.1; XM_638992.1.
DR   AlphaFoldDB; Q86HL8; -.
DR   SMR; Q86HL8; -.
DR   PaxDb; Q86HL8; -.
DR   PRIDE; Q86HL8; -.
DR   EnsemblProtists; EAL70151; EAL70151; DDB_G0274517.
DR   GeneID; 8619513; -.
DR   KEGG; ddi:DDB_G0274517; -.
DR   dictyBase; DDB_G0274517; osbE.
DR   eggNOG; KOG2210; Eukaryota.
DR   HOGENOM; CLU_706815_0_0_1; -.
DR   InParanoid; Q86HL8; -.
DR   PhylomeDB; Q86HL8; -.
DR   Reactome; R-DDI-1482801; Acyl chain remodelling of PS.
DR   Reactome; R-DDI-192105; Synthesis of bile acids and bile salts.
DR   Reactome; R-DDI-9013407; RHOH GTPase cycle.
DR   PRO; PR:Q86HL8; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   PANTHER; PTHR10972; PTHR10972; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   SUPFAM; SSF144000; SSF144000; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..362
FT                   /note="Oxysterol-binding protein 5"
FT                   /id="PRO_0000328469"
SQ   SEQUENCE   362 AA;  42447 MW;  CC6B87083F4813E4 CRC64;
     MEKDSKVIEK EGNKGFTKSI ISTVKNIKLG YGMDIYQMST PASLIAPYSS LTYISDSFSK
     NFEILIKANS IENDLDRLLE IFKYITTIFI INNNACGKPI VPIVGETQRF KFSNKDEDGN
     EFNDSFHCAE HVQNSPFPLS VSSTVNEKEG IELCYNYAAK ILFMATYFRI NIDEAETFIK
     FNKFNETYNI ILPTLYTRIF RGFSEYSGKL KIEPTKSNYY IDANFQSKPL IGGKYNYFEA
     YVSKKDTDEK IYKIFGQWDK EQQILDFENY QTDFFFKRPQ QFYEKQLPNE ILPTDSSVVW
     KGLIDAHNCG NNKLKLKEKT KVDEDQKLIE NQRKKENINF KPKFFIKNKE TDKWELDKFN
     KY