ID   OSB6_DICDI              Reviewed;         439 AA.
AC   Q86HV4; Q551J4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Oxysterol-binding protein 6;
DE   AltName: Full=OSBPf;
GN   Name=osbF; ORFNames=DDB_G0276427;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
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DR   EMBL; AAFI02000015; EAL69167.1; -; Genomic_DNA.
DR   RefSeq; XP_643140.1; XM_638048.1.
DR   AlphaFoldDB; Q86HV4; -.
DR   SMR; Q86HV4; -.
DR   STRING; 44689.DDB0237795; -.
DR   PaxDb; Q86HV4; -.
DR   EnsemblProtists; EAL69167; EAL69167; DDB_G0276427.
DR   GeneID; 8620546; -.
DR   KEGG; ddi:DDB_G0276427; -.
DR   dictyBase; DDB_G0276427; osbF.
DR   eggNOG; KOG2210; Eukaryota.
DR   HOGENOM; CLU_012334_1_2_1; -.
DR   InParanoid; Q86HV4; -.
DR   OMA; LEGLWYM; -.
DR   PhylomeDB; Q86HV4; -.
DR   Reactome; R-DDI-1482801; Acyl chain remodelling of PS.
DR   Reactome; R-DDI-192105; Synthesis of bile acids and bile salts.
DR   Reactome; R-DDI-9013407; RHOH GTPase cycle.
DR   PRO; PR:Q86HV4; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   PANTHER; PTHR10972; PTHR10972; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   SUPFAM; SSF144000; SSF144000; 1.
DR   PROSITE; PS01013; OSBP; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..439
FT                   /note="Oxysterol-binding protein 6"
FT                   /id="PRO_0000328474"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          409..439
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   439 AA;  49590 MW;  65F0C94E40E4AAD9 CRC64;
     MSAKVASNKE APLTEDSVSD LSSDGVEAEG VDQTENSGAD AMIDSEPATE AGVMKQAFGF
     IKNHLKVGAD MTKLPIPATF VQPISFLTAI QQQSAIFSHL LTSAPYIKED DQRFLQVLKY
     HLTWPKMYFP KNPLNPILGE VYECQVQHTD EKTNEVIQGD ITHFTAEQIS HHPPISCFNF
     YNDKHKIKFD SKQQITPVFK GKCIRVNMDV KTCITLEREG GVTETYFNDK FTEGYLRLLR
     WKFEFTGKYN FVCPETGYSA VINFKDKPII GGKWHDLQII VSKGTEPIYD IHGTHVDILT
     ITNLKDKTSG VFINYNTMRS EPVIEEPMEQ LKENASQKVW KGVAEGFAKK DSRKAGLEKQ
     RIEDLQRKKA KVNLAKDPNF IHKPHYFIHN PNLPADCVKP DYIFKKPVES STPNLSKVDS
     SAKIENSIPV DNSIPQTTN