ID   OSB8_DICDI              Reviewed;         402 AA.
AC   Q54QP6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Oxysterol-binding protein 8;
DE   AltName: Full=OSBPh;
GN   Name=osbH; ORFNames=DDB_G0283709;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=AX2;
RX   PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA   Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA   Soldati T.;
RT   "Proteomics fingerprinting of phagosome maturation and evidence for the
RT   role of a Galpha during uptake.";
RL   Mol. Cell. Proteomics 5:2228-2243(2006).
CC   -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
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DR   EMBL; AAFI02000056; EAL65621.1; -; Genomic_DNA.
DR   RefSeq; XP_638977.1; XM_633885.1.
DR   AlphaFoldDB; Q54QP6; -.
DR   SMR; Q54QP6; -.
DR   STRING; 44689.DDB0237794; -.
DR   PaxDb; Q54QP6; -.
DR   EnsemblProtists; EAL65621; EAL65621; DDB_G0283709.
DR   GeneID; 8624223; -.
DR   KEGG; ddi:DDB_G0283709; -.
DR   dictyBase; DDB_G0283709; osbH.
DR   eggNOG; KOG1737; Eukaryota.
DR   HOGENOM; CLU_007105_6_0_1; -.
DR   InParanoid; Q54QP6; -.
DR   OMA; AHSAKMY; -.
DR   PhylomeDB; Q54QP6; -.
DR   Reactome; R-DDI-192105; Synthesis of bile acids and bile salts.
DR   PRO; PR:Q54QP6; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   PANTHER; PTHR10972; PTHR10972; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   SUPFAM; SSF144000; SSF144000; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..402
FT                   /note="Oxysterol-binding protein 8"
FT                   /id="PRO_0000328471"
FT   COILED          328..361
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   402 AA;  45957 MW;  99219AFCF57AB5A9 CRC64;
     MFSGALNYMK GLVGTNENLQ VEESGDNKGD IEPEQRKGLL KQLSSYVGKD ITSLISLPVW
     IFEPVSFLQV MSEPLQYNAL LSKASKQDSE FLCLAYLAAF NCALYSTAVR TRKPFNPILG
     ETFEIVDKKG EFRFLAEQVS HHPPIGVSET ISEDYTLQLE TLLKSKFYGN SSEVEIDGTN
     HFFNKKTNHH YTWNHLVTCC HNIIIGSLWL DHYGDLVIEN HTTGSKAVLK FAKSGWLGAG
     RYGVTGEIVD CEGDVRYRIT GKWNESIQLF QVMDNGSSST TSTCLWEASK EPINNKFLFP
     RWVEENVIDL NDEYKKILPV TDSRLRADRI ALEEGNLDVA AKEKHNLEEK QREDKRQRVA
     ENKEWETAQF KKVDDAKFGY RWNYCGNYWE EREERVKAAA SN