OSCAR_HUMAN
ID OSCAR_HUMAN Reviewed; 282 AA.
AC Q8IYS5; B7WNS2; Q5GRG5; Q8N763; Q8NHL4; Q8WXQ0; Q8WXQ1; Q8WXQ2;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Osteoclast-associated immunoglobulin-like receptor;
DE Short=Osteoclast-associated receptor;
DE Short=hOSCAR;
DE AltName: Full=Polymeric immunoglobulin receptor 3;
DE Short=PIgR-3;
DE Short=PIgR3;
DE Short=Poly-Ig receptor 3;
DE Flags: Precursor;
GN Name=OSCAR;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT SER-97.
RA Zhang W., Li N., Wan T., Cao X.;
RT "Novel PIGR2.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 6).
RX PubMed=11805147; DOI=10.1084/jem.20011681;
RA Kim N., Takami M., Rho J., Josien R., Choi Y.;
RT "A novel member of the leukocyte receptor complex regulates osteoclast
RT differentiation.";
RL J. Exp. Med. 195:201-209(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 5), AND VARIANT SER-97.
RA Isogai T., Sugiyama T., Otsuki T., Wakamatsu A., Sato H., Ishii S.,
RA Yamamoto J., Isono Y., Hio Y., Otsuka K., Nagai K., Irie R., Tamechika I.,
RA Seki N., Yoshikawa T., Otsuka M., Nagahari K., Masuho Y.;
RT "Full-length cDNA sequences.";
RL Patent number EP1308459, 20-JUN-2003.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7), AND VARIANT
RP SER-97.
RC TISSUE=Macrophage;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT SER-97.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Regulator of osteoclastogenesis which plays an important
CC bone-specific function in osteoclast differentiation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305}; Single-
CC pass type I membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=7;
CC Name=1; Synonyms=OSCAR-S1;
CC IsoId=Q8IYS5-1; Sequence=Displayed;
CC Name=2; Synonyms=OSCAR-M1;
CC IsoId=Q8IYS5-2; Sequence=VSP_029355;
CC Name=3; Synonyms=OSCAR-M2;
CC IsoId=Q8IYS5-3; Sequence=VSP_029353, VSP_029355;
CC Name=4; Synonyms=OSCAR-S2;
CC IsoId=Q8IYS5-4; Sequence=VSP_029352;
CC Name=5;
CC IsoId=Q8IYS5-5; Sequence=VSP_029354;
CC Name=7;
CC IsoId=Q8IYS5-7; Sequence=VSP_029353;
CC Name=6; Synonyms=OSCAR-M3;
CC IsoId=Q8IYS5-6; Sequence=VSP_029352, VSP_029355;
CC -!- SIMILARITY: Belongs to the leukocyte receptor complex/polymeric
CC immunoglobulin receptor (PIR/LRC) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF251702; AAM19095.1; -; mRNA.
DR EMBL; AF391162; AAL68495.1; -; mRNA.
DR EMBL; AF391163; AAL68496.1; -; mRNA.
DR EMBL; AF391164; AAL68497.1; -; mRNA.
DR EMBL; AF474152; AAQ05766.1; -; mRNA.
DR EMBL; AF474153; AAQ05767.1; -; mRNA.
DR EMBL; AX746784; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK091111; BAC03586.1; -; mRNA.
DR EMBL; AK130199; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC012314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC035023; AAH35023.1; -; mRNA.
DR CCDS; CCDS12873.1; -. [Q8IYS5-3]
DR CCDS; CCDS12874.1; -. [Q8IYS5-6]
DR CCDS; CCDS12875.1; -. [Q8IYS5-2]
DR CCDS; CCDS12876.1; -. [Q8IYS5-7]
DR CCDS; CCDS62789.1; -. [Q8IYS5-4]
DR CCDS; CCDS74444.1; -. [Q8IYS5-1]
DR RefSeq; NP_001269278.1; NM_001282349.1.
DR RefSeq; NP_001269279.1; NM_001282350.1.
DR RefSeq; NP_570127.3; NM_130771.4.
DR RefSeq; NP_573398.2; NM_133168.4.
DR RefSeq; NP_573399.2; NM_133169.4.
DR RefSeq; NP_996554.2; NM_206818.2.
DR PDB; 5CJ8; X-ray; 2.02 A; A=31-215.
DR PDB; 5CJB; X-ray; 2.40 A; A=31-215.
DR PDB; 5EIQ; X-ray; 2.01 A; A=28-215.
DR PDB; 5EIV; X-ray; 2.41 A; A/B=26-215.
DR PDBsum; 5CJ8; -.
DR PDBsum; 5CJB; -.
DR PDBsum; 5EIQ; -.
DR PDBsum; 5EIV; -.
DR AlphaFoldDB; Q8IYS5; -.
DR SMR; Q8IYS5; -.
DR BioGRID; 125947; 5.
DR IntAct; Q8IYS5; 2.
DR STRING; 9606.ENSP00000479089; -.
DR GlyGen; Q8IYS5; 3 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q8IYS5; -.
DR BioMuta; OSCAR; -.
DR DMDM; 311033418; -.
DR jPOST; Q8IYS5; -.
DR MassIVE; Q8IYS5; -.
DR PaxDb; Q8IYS5; -.
DR PeptideAtlas; Q8IYS5; -.
DR PRIDE; Q8IYS5; -.
DR ProteomicsDB; 71224; -. [Q8IYS5-1]
DR ProteomicsDB; 71225; -. [Q8IYS5-2]
DR ProteomicsDB; 71226; -. [Q8IYS5-3]
DR ProteomicsDB; 71227; -. [Q8IYS5-4]
DR ProteomicsDB; 71228; -. [Q8IYS5-5]
DR ProteomicsDB; 71229; -. [Q8IYS5-6]
DR ProteomicsDB; 71230; -. [Q8IYS5-7]
DR Antibodypedia; 32787; 227 antibodies from 27 providers.
DR DNASU; 126014; -.
DR Ensembl; ENST00000284648.10; ENSP00000365808.2; ENSG00000170909.14.
DR Ensembl; ENST00000391761.5; ENSP00000375641.1; ENSG00000170909.14.
DR Ensembl; ENST00000610577.4; ENSP00000478594.1; ENSG00000276982.4. [Q8IYS5-7]
DR Ensembl; ENST00000610915.4; ENSP00000479317.1; ENSG00000277088.4. [Q8IYS5-4]
DR Ensembl; ENST00000610985.4; ENSP00000484755.1; ENSG00000274703.4. [Q8IYS5-7]
DR Ensembl; ENST00000611143.4; ENSP00000477994.1; ENSG00000278533.4. [Q8IYS5-3]
DR Ensembl; ENST00000611480.4; ENSP00000480193.1; ENSG00000275551.4. [Q8IYS5-1]
DR Ensembl; ENST00000611535.4; ENSP00000483744.1; ENSG00000275736.4. [Q8IYS5-2]
DR Ensembl; ENST00000611715.4; ENSP00000478382.1; ENSG00000278533.4. [Q8IYS5-4]
DR Ensembl; ENST00000611719.4; ENSP00000478099.1; ENSG00000275644.4. [Q8IYS5-4]
DR Ensembl; ENST00000611918.4; ENSP00000482460.1; ENSG00000276982.4. [Q8IYS5-4]
DR Ensembl; ENST00000611987.4; ENSP00000478027.1; ENSG00000276982.4. [Q8IYS5-3]
DR Ensembl; ENST00000612289.4; ENSP00000482414.1; ENSG00000277088.4. [Q8IYS5-1]
DR Ensembl; ENST00000612406.4; ENSP00000478224.1; ENSG00000273511.4. [Q8IYS5-7]
DR Ensembl; ENST00000612953.4; ENSP00000479954.1; ENSG00000275644.4. [Q8IYS5-7]
DR Ensembl; ENST00000613426.4; ENSP00000480900.1; ENSG00000275736.4. [Q8IYS5-1]
DR Ensembl; ENST00000613814.1; ENSP00000484125.1; ENSG00000275736.4. [Q8IYS5-4]
DR Ensembl; ENST00000614003.4; ENSP00000481647.1; ENSG00000274703.4. [Q8IYS5-1]
DR Ensembl; ENST00000614380.4; ENSP00000482734.1; ENSG00000277088.4. [Q8IYS5-7]
DR Ensembl; ENST00000615074.4; ENSP00000477845.1; ENSG00000275736.4. [Q8IYS5-7]
DR Ensembl; ENST00000615546.4; ENSP00000482402.1; ENSG00000275551.4. [Q8IYS5-4]
DR Ensembl; ENST00000616215.4; ENSP00000479628.1; ENSG00000170909.14.
DR Ensembl; ENST00000616227.4; ENSP00000479849.1; ENSG00000275736.4. [Q8IYS5-7]
DR Ensembl; ENST00000616232.4; ENSP00000484567.1; ENSG00000274703.4. [Q8IYS5-4]
DR Ensembl; ENST00000616461.4; ENSP00000482610.1; ENSG00000278533.4. [Q8IYS5-7]
DR Ensembl; ENST00000616758.4; ENSP00000481785.1; ENSG00000278533.4. [Q8IYS5-1]
DR Ensembl; ENST00000617187.4; ENSP00000481805.1; ENSG00000275551.4. [Q8IYS5-7]
DR Ensembl; ENST00000617210.4; ENSP00000482359.1; ENSG00000278378.4. [Q8IYS5-3]
DR Ensembl; ENST00000617622.4; ENSP00000480863.1; ENSG00000273511.4. [Q8IYS5-1]
DR Ensembl; ENST00000617834.4; ENSP00000481147.1; ENSG00000275551.4. [Q8IYS5-3]
DR Ensembl; ENST00000617993.4; ENSP00000481261.1; ENSG00000278378.4. [Q8IYS5-7]
DR Ensembl; ENST00000618710.4; ENSP00000484323.1; ENSG00000278378.4. [Q8IYS5-1]
DR Ensembl; ENST00000619170.4; ENSP00000482545.1; ENSG00000273511.4. [Q8IYS5-3]
DR Ensembl; ENST00000619287.4; ENSP00000484977.1; ENSG00000275736.4. [Q8IYS5-6]
DR Ensembl; ENST00000619631.4; ENSP00000484878.1; ENSG00000273511.4. [Q8IYS5-4]
DR Ensembl; ENST00000620283.4; ENSP00000483090.1; ENSG00000274703.4. [Q8IYS5-3]
DR Ensembl; ENST00000620647.4; ENSP00000478216.1; ENSG00000275644.4. [Q8IYS5-1]
DR Ensembl; ENST00000621284.4; ENSP00000477825.1; ENSG00000275736.4. [Q8IYS5-4]
DR Ensembl; ENST00000621290.4; ENSP00000482791.1; ENSG00000275736.4. [Q8IYS5-3]
DR Ensembl; ENST00000621328.4; ENSP00000482997.1; ENSG00000275644.4. [Q8IYS5-3]
DR Ensembl; ENST00000621506.4; ENSP00000480424.1; ENSG00000278378.4. [Q8IYS5-4]
DR Ensembl; ENST00000621788.4; ENSP00000481926.1; ENSG00000275736.4. [Q8IYS5-3]
DR Ensembl; ENST00000622288.4; ENSP00000484602.1; ENSG00000277088.4. [Q8IYS5-3]
DR Ensembl; ENST00000622326.4; ENSP00000481257.1; ENSG00000276982.4. [Q8IYS5-1]
DR GeneID; 126014; -.
DR KEGG; hsa:126014; -.
DR UCSC; uc002qdc.5; human. [Q8IYS5-1]
DR CTD; 126014; -.
DR DisGeNET; 126014; -.
DR GeneCards; OSCAR; -.
DR HGNC; HGNC:29960; OSCAR.
DR HPA; ENSG00000170909; Group enriched (bone marrow, lung, lymphoid tissue).
DR MIM; 606862; gene.
DR neXtProt; NX_Q8IYS5; -.
DR PharmGKB; PA162398474; -.
DR VEuPathDB; HostDB:ENSG00000170909; -.
DR eggNOG; ENOG502T2B6; Eukaryota.
DR InParanoid; Q8IYS5; -.
DR OrthoDB; 1327293at2759; -.
DR PhylomeDB; Q8IYS5; -.
DR TreeFam; TF336644; -.
DR PathwayCommons; Q8IYS5; -.
DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR SignaLink; Q8IYS5; -.
DR BioGRID-ORCS; 126014; 15 hits in 1067 CRISPR screens.
DR GeneWiki; OSCAR_(gene); -.
DR GenomeRNAi; 126014; -.
DR Pharos; Q8IYS5; Tbio.
DR PRO; PR:Q8IYS5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8IYS5; protein.
DR Bgee; ENSG00000170909; Expressed in monocyte and 93 other tissues.
DR ExpressionAtlas; Q8IYS5; baseline and differential.
DR Genevisible; Q8IYS5; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0035580; C:specific granule lumen; TAS:Reactome.
DR GO; GO:1904724; C:tertiary granule lumen; TAS:Reactome.
DR GO; GO:0038064; F:collagen receptor activity; IDA:MGI.
DR GO; GO:0030316; P:osteoclast differentiation; IMP:MGI.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR Pfam; PF13895; Ig_2; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cell membrane; Disulfide bond;
KW Glycoprotein; Immunoglobulin domain; Membrane; Receptor;
KW Reference proteome; Repeat; Secreted; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..282
FT /note="Osteoclast-associated immunoglobulin-like receptor"
FT /id="PRO_0000310951"
FT DOMAIN 22..116
FT /note="Ig-like 1"
FT DOMAIN 126..219
FT /note="Ig-like 2"
FT REGION 221..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 145
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 53..100
FT /evidence="ECO:0000250"
FT VAR_SEQ 13..25
FT /note="WPLCHTDITPSVP -> FP (in isoform 4 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:11805147"
FT /id="VSP_029352"
FT VAR_SEQ 24
FT /note="V -> VAIIV (in isoform 3 and isoform 7)"
FT /evidence="ECO:0000303|PubMed:11805147,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_029353"
FT VAR_SEQ 129..134
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029354"
FT VAR_SEQ 219..282
FT /note="GEGPEARPASSAPGMQAPGPPPSDPGAQAPSLSSFRPRGLVLQPLLPQTQDS
FT WDPAPPPSDPGV -> DSGSSDYTRGNLVRLGLAGLVLISLGALVTFDWRSQNRAPAGI
FT RP (in isoform 2, isoform 3 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:11805147, ECO:0000303|Ref.1"
FT /id="VSP_029355"
FT VARIANT 97
FT /note="I -> S (in dbSNP:rs1657535)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1,
FT ECO:0000269|Ref.3"
FT /id="VAR_037108"
FT VARIANT 229
FT /note="S -> Y (in dbSNP:rs8106130)"
FT /id="VAR_047393"
FT CONFLICT 158
FT /note="S -> N (in Ref. 1; AAM19095)"
FT /evidence="ECO:0000305"
FT CONFLICT 194
FT /note="S -> G (in Ref. 4; BAC03586 and 5; AX746784)"
FT /evidence="ECO:0000305"
FT STRAND 34..39
FT /evidence="ECO:0007829|PDB:5EIQ"
FT STRAND 41..43
FT /evidence="ECO:0007829|PDB:5EIQ"
FT STRAND 49..65
FT /evidence="ECO:0007829|PDB:5EIQ"
FT STRAND 73..87
FT /evidence="ECO:0007829|PDB:5EIQ"
FT HELIX 92..94
FT /evidence="ECO:0007829|PDB:5EIQ"
FT STRAND 96..103
FT /evidence="ECO:0007829|PDB:5EIQ"
FT HELIX 105..107
FT /evidence="ECO:0007829|PDB:5EIV"
FT STRAND 119..123
FT /evidence="ECO:0007829|PDB:5EIQ"
FT STRAND 125..127
FT /evidence="ECO:0007829|PDB:5EIQ"
FT STRAND 131..134
FT /evidence="ECO:0007829|PDB:5EIQ"
FT STRAND 146..151
FT /evidence="ECO:0007829|PDB:5EIQ"
FT STRAND 158..163
FT /evidence="ECO:0007829|PDB:5EIQ"
FT STRAND 166..174
FT /evidence="ECO:0007829|PDB:5EIQ"
FT STRAND 176..184
FT /evidence="ECO:0007829|PDB:5EIQ"
FT TURN 186..188
FT /evidence="ECO:0007829|PDB:5EIQ"
FT STRAND 191..198
FT /evidence="ECO:0007829|PDB:5EIQ"
FT STRAND 200..203
FT /evidence="ECO:0007829|PDB:5EIQ"
FT STRAND 213..215
FT /evidence="ECO:0007829|PDB:5EIQ"
SQ SEQUENCE 282 AA; 30481 MW; 1C0A86B90DA6F5CD CRC64;
MALVLILQLL TLWPLCHTDI TPSVPPASYH PKPWLGAQPA TVVTPGVNVT LRCRAPQPAW
RFGLFKPGEI APLLFRDVSS ELAEFFLEEV TPAQGGIYRC CYRRPDWGPG VWSQPSDVLE
LLVTEELPRP SLVALPGPVV GPGANVSLRC AGRLRNMSFV LYREGVAAPL QYRHSAQPWA
DFTLLGARAP GTYSCYYHTP SAPYVLSQRS EVLVISWEGE GPEARPASSA PGMQAPGPPP
SDPGAQAPSL SSFRPRGLVL QPLLPQTQDS WDPAPPPSDP GV
