OSCAR_MOUSE
ID OSCAR_MOUSE Reviewed; 265 AA.
AC Q8VBT3; Q8VHT9;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Osteoclast-associated immunoglobulin-like receptor;
DE Short=Osteoclast-associated receptor;
DE Short=mOSCAR;
DE AltName: Full=Ocl178;
DE Flags: Precursor;
GN Name=Oscar;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=11805147; DOI=10.1084/jem.20011681;
RA Kim N., Takami M., Rho J., Josien R., Choi Y.;
RT "A novel member of the leukocyte receptor complex regulates osteoclast
RT differentiation.";
RL J. Exp. Med. 195:201-209(2002).
CC -!- FUNCTION: Regulator of osteoclastogenesis which plays an important
CC bone-specific function in osteoclast differentiation.
CC {ECO:0000269|PubMed:11805147}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=OSCAR-M2;
CC IsoId=Q8VBT3-1; Sequence=Displayed;
CC Name=2; Synonyms=OSCAR-M3;
CC IsoId=Q8VBT3-2; Sequence=VSP_029356;
CC -!- TISSUE SPECIFICITY: Specifically expressed in preosteoclasts or mature
CC osteoclasts. {ECO:0000269|PubMed:11805147}.
CC -!- SIMILARITY: Belongs to the leukocyte receptor complex/polymeric
CC immunoglobulin receptor (PIR/LRC) family. {ECO:0000305}.
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DR EMBL; AF391159; AAL68492.1; -; mRNA.
DR EMBL; AF391160; AAL68493.1; -; mRNA.
DR EMBL; AF391161; AAL68494.1; -; mRNA.
DR CCDS; CCDS20718.1; -. [Q8VBT3-2]
DR CCDS; CCDS71872.1; -. [Q8VBT3-1]
DR RefSeq; NP_001277306.1; NM_001290377.1. [Q8VBT3-1]
DR RefSeq; NP_783440.1; NM_175632.3. [Q8VBT3-2]
DR AlphaFoldDB; Q8VBT3; -.
DR SMR; Q8VBT3; -.
DR STRING; 10090.ENSMUSP00000041306; -.
DR GlyGen; Q8VBT3; 2 sites.
DR PaxDb; Q8VBT3; -.
DR PRIDE; Q8VBT3; -.
DR Antibodypedia; 32787; 227 antibodies from 27 providers.
DR DNASU; 232790; -.
DR Ensembl; ENSMUST00000039507; ENSMUSP00000041306; ENSMUSG00000054594. [Q8VBT3-2]
DR Ensembl; ENSMUST00000108645; ENSMUSP00000104285; ENSMUSG00000054594. [Q8VBT3-1]
DR GeneID; 232790; -.
DR KEGG; mmu:232790; -.
DR UCSC; uc009evb.2; mouse. [Q8VBT3-2]
DR UCSC; uc009evc.1; mouse. [Q8VBT3-1]
DR CTD; 126014; -.
DR MGI; MGI:2179720; Oscar.
DR VEuPathDB; HostDB:ENSMUSG00000054594; -.
DR eggNOG; ENOG502T2B6; Eukaryota.
DR GeneTree; ENSGT01050000244944; -.
DR InParanoid; Q8VBT3; -.
DR OMA; CELSLPW; -.
DR OrthoDB; 1327293at2759; -.
DR PhylomeDB; Q8VBT3; -.
DR TreeFam; TF336644; -.
DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 232790; 3 hits in 74 CRISPR screens.
DR PRO; PR:Q8VBT3; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8VBT3; protein.
DR Bgee; ENSMUSG00000054594; Expressed in morula and 29 other tissues.
DR ExpressionAtlas; Q8VBT3; baseline and differential.
DR Genevisible; Q8VBT3; MM.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0038064; F:collagen receptor activity; IMP:MGI.
DR GO; GO:0038094; P:Fc-gamma receptor signaling pathway; IMP:MGI.
DR GO; GO:0072674; P:multinuclear osteoclast differentiation; IMP:MGI.
DR GO; GO:0030316; P:osteoclast differentiation; IDA:MGI.
DR GO; GO:0045780; P:positive regulation of bone resorption; IMP:MGI.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF13895; Ig_2; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..265
FT /note="Osteoclast-associated immunoglobulin-like receptor"
FT /id="PRO_0000310952"
FT TOPO_DOM 19..231
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..265
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 22..115
FT /note="Ig-like 1"
FT DOMAIN 125..218
FT /note="Ig-like 2"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 52..99
FT /evidence="ECO:0000250"
FT VAR_SEQ 12
FT /note="L -> LCELSLP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11805147"
FT /id="VSP_029356"
SQ SEQUENCE 265 AA; 28726 MW; E2E5F1E2CA037DBC CRC64;
MVLSLILQLS TLWPACRADF TPTAPLASYP QPWLGAHPAA VVTPGINVTL TCRAPQSAWR
FALFKSGLVT PLLLRDVSVE LAEFFLEEVT PAQGGSYHCR YRKTDWGPGV WSQPSNVLEL
LVTDQLPRPS LVALPGPVVA PGANVSLRCA GRIPGMSFAL YRVGVATPLQ YIDSVQPWAD
FLLIGTHTPG TYCCYYHTPS APYVLSQRSQ PLVISFEGSG SLDYTQGNLI RLGLAGMVLI
CLGIIVTCDW HSRSSAFDGL LPQQN
