OSCP1_HUMAN
ID OSCP1_HUMAN Reviewed; 389 AA.
AC Q8WVF1; A6NHM5; A6NHS9; A6NIN9; Q4AEJ0; Q8N7G2; Q8TDF1;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 4.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Protein OSCP1;
DE Short=hOSCP1;
DE AltName: Full=Organic solute transport protein 1;
DE AltName: Full=Oxidored-nitro domain-containing protein 1;
GN Name=OSCP1; Synonyms=C1orf102, NOR1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, AND VARIANT
RP ARG-31.
RX PubMed=12819961; DOI=10.1007/s00432-003-0451-9;
RA Nie X., Zhang B., Li X., Xiang J., Xiao B., Ma J., Zhou M., Zhu S., Lu H.,
RA Gui R., Shen S., Li G.;
RT "Cloning, expression, and mutation analysis of NOR1, a novel human gene
RT down-regulated in HNE-1 nasopharyngeal carcinoma cell line.";
RL J. Cancer Res. Clin. Oncol. 129:410-414(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, BIOPHYSICOCHEMICAL
RP PROPERTIES, TISSUE SPECIFICITY, AND VARIANT ALA-141.
RC TISSUE=Placenta;
RX PubMed=16006562; DOI=10.1074/jbc.m504246200;
RA Kobayashi Y., Shibusawa A., Saito H., Ohshiro N., Ohbayashi M., Kohyama N.,
RA Yamamoto T.;
RT "Isolation and functional characterization of a novel organic solute
RT carrier protein, hOSCP1.";
RL J. Biol. Chem. 280:32332-32339(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT ARG-31.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in drug clearance in the placenta.
CC {ECO:0000269|PubMed:16006562}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Kinetic parameters:
CC KM=35.0 uM for p-aminohippurate (PAH) {ECO:0000269|PubMed:16006562};
CC KM=62.3 uM for tetraethylammonium {ECO:0000269|PubMed:16006562};
CC Note=In Xenopus laevis oocytes, in a sodium-independent manner.;
CC -!- SUBCELLULAR LOCATION: Basal cell membrane. Note=Syncytiotrophoblast in
CC placenta.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8WVF1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WVF1-2; Sequence=VSP_020826;
CC Name=3;
CC IsoId=Q8WVF1-3; Sequence=VSP_039475;
CC Name=4;
CC IsoId=Q8WVF1-4; Sequence=VSP_039475, VSP_039476, VSP_039477;
CC -!- TISSUE SPECIFICITY: Expressed predominantly in testis, also found in
CC placenta and to a lesser extent in thymus and small intestine;
CC abundantly expressed in tumor-derived cell lines (PubMed:16006562).
CC Ubiquitously expressed (PubMed:12819961). {ECO:0000269|PubMed:12819961,
CC ECO:0000269|PubMed:16006562}.
CC -!- MISCELLANEOUS: May be involved in the development and/or progression of
CC nosopharyngeal carcinoma.
CC -!- CAUTION: The polymorphism 'Glu58Gly' (described in PubMed:12819961) is
CC in fact an error, the G to A change described representing a synonymous
CC mutation that does not induce any amino acid change in Gly-32.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL89738.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF462348; AAL89738.1; ALT_INIT; mRNA.
DR EMBL; AB079075; BAE16984.1; -; mRNA.
DR EMBL; AK098541; BAC05326.1; -; mRNA.
DR EMBL; AC119675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX07365.1; -; Genomic_DNA.
DR EMBL; BC018069; AAH18069.2; -; mRNA.
DR CCDS; CCDS409.2; -. [Q8WVF1-3]
DR CCDS; CCDS410.1; -. [Q8WVF1-4]
DR CCDS; CCDS81301.1; -. [Q8WVF1-1]
DR RefSeq; NP_001317422.1; NM_001330493.1. [Q8WVF1-1]
DR RefSeq; NP_659484.4; NM_145047.4. [Q8WVF1-3]
DR RefSeq; NP_996668.1; NM_206837.2. [Q8WVF1-4]
DR AlphaFoldDB; Q8WVF1; -.
DR BioGRID; 126078; 15.
DR IntAct; Q8WVF1; 5.
DR STRING; 9606.ENSP00000235532; -.
DR TCDB; 9.B.68.1.1; the putative na-independent organic solute carrier protein (oscp1) family.
DR iPTMnet; Q8WVF1; -.
DR PhosphoSitePlus; Q8WVF1; -.
DR BioMuta; OSCP1; -.
DR DMDM; 300669715; -.
DR EPD; Q8WVF1; -.
DR jPOST; Q8WVF1; -.
DR MassIVE; Q8WVF1; -.
DR MaxQB; Q8WVF1; -.
DR PaxDb; Q8WVF1; -.
DR PeptideAtlas; Q8WVF1; -.
DR PRIDE; Q8WVF1; -.
DR ProteomicsDB; 74786; -. [Q8WVF1-1]
DR ProteomicsDB; 74787; -. [Q8WVF1-2]
DR ProteomicsDB; 74788; -. [Q8WVF1-3]
DR ProteomicsDB; 74789; -. [Q8WVF1-4]
DR Antibodypedia; 31691; 63 antibodies from 19 providers.
DR DNASU; 127700; -.
DR Ensembl; ENST00000235532.9; ENSP00000235532.5; ENSG00000116885.18. [Q8WVF1-3]
DR Ensembl; ENST00000354267.3; ENSP00000346216.3; ENSG00000116885.18. [Q8WVF1-4]
DR Ensembl; ENST00000356637.9; ENSP00000349052.5; ENSG00000116885.18. [Q8WVF1-1]
DR GeneID; 127700; -.
DR KEGG; hsa:127700; -.
DR MANE-Select; ENST00000235532.9; ENSP00000235532.5; NM_145047.5; NP_659484.4. [Q8WVF1-3]
DR UCSC; uc001caq.4; human. [Q8WVF1-1]
DR CTD; 127700; -.
DR DisGeNET; 127700; -.
DR GeneCards; OSCP1; -.
DR HGNC; HGNC:29971; OSCP1.
DR HPA; ENSG00000116885; Tissue enhanced (fallopian tube, testis).
DR MIM; 608854; gene.
DR neXtProt; NX_Q8WVF1; -.
DR OpenTargets; ENSG00000116885; -.
DR PharmGKB; PA165752125; -.
DR VEuPathDB; HostDB:ENSG00000116885; -.
DR eggNOG; KOG4033; Eukaryota.
DR GeneTree; ENSGT00390000004808; -.
DR HOGENOM; CLU_039360_1_0_1; -.
DR InParanoid; Q8WVF1; -.
DR OMA; MMVKYQL; -.
DR OrthoDB; 1398008at2759; -.
DR PhylomeDB; Q8WVF1; -.
DR TreeFam; TF105789; -.
DR PathwayCommons; Q8WVF1; -.
DR SignaLink; Q8WVF1; -.
DR BioGRID-ORCS; 127700; 6 hits in 1067 CRISPR screens.
DR ChiTaRS; OSCP1; human.
DR GenomeRNAi; 127700; -.
DR Pharos; Q8WVF1; Tbio.
DR PRO; PR:Q8WVF1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8WVF1; protein.
DR Bgee; ENSG00000116885; Expressed in right uterine tube and 99 other tissues.
DR ExpressionAtlas; Q8WVF1; baseline and differential.
DR Genevisible; Q8WVF1; HS.
DR GO; GO:0009925; C:basal plasma membrane; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IMP:UniProtKB.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IMP:UniProtKB.
DR InterPro; IPR019332; OSCP1.
DR PANTHER; PTHR21439; PTHR21439; 1.
DR Pfam; PF10188; Oscp1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Membrane; Reference proteome;
KW Transport.
FT CHAIN 1..389
FT /note="Protein OSCP1"
FT /id="PRO_0000251965"
FT VAR_SEQ 38..47
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:12819961,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:16006562"
FT /id="VSP_039475"
FT VAR_SEQ 183..231
FT /note="VSMFLKDKVQNNNGRFVLPVSGPVPWGTEVPGLIRMFNNKGEEVKRIEF ->
FT RECFWKHMQETVHSAQCCLPGVGNYMEDRRRRLTFHYVYPFENFEFCTWAK (in
FT isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_039476"
FT VAR_SEQ 232..389
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_039477"
FT VAR_SEQ 329..378
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_020826"
FT VARIANT 31
FT /note="P -> R (in dbSNP:rs11547025)"
FT /evidence="ECO:0000269|PubMed:12819961,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_027741"
FT VARIANT 141
FT /note="T -> A (in dbSNP:rs34409118)"
FT /evidence="ECO:0000269|PubMed:16006562"
FT /id="VAR_056958"
FT VARIANT 242
FT /note="K -> E (in dbSNP:rs2359016)"
FT /id="VAR_027742"
FT CONFLICT 51
FT /note="D -> G (in Ref. 3; BAC05326)"
FT /evidence="ECO:0000305"
FT CONFLICT 317
FT /note="G -> R (in Ref. 2; BAE16984)"
FT /evidence="ECO:0000305"
FT CONFLICT 377
FT /note="S -> G (in Ref. 1; AAL89738 and 5; AAH18069)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 389 AA; 44586 MW; 8EA5C1EF2D9973F4 CRC64;
MSVRTLPLLF LNLGGEMLYI LDQRLRAQNI PGDKARKDEW TEVDRKRVLN DIISTMFNRK
FMEELFKPQE LYSKKALRTV YERLAHASIM KLNQASMDKL YDLMTMAFKY QVLLCPRPKD
VLLVTFNHLD TIKGFIRDSP TILQQVDETL RQLTEIYGGL SAGEFQLIRQ TLLIFFQDLH
IRVSMFLKDK VQNNNGRFVL PVSGPVPWGT EVPGLIRMFN NKGEEVKRIE FKHGGNYVPA
PKEGSFELYG DRVLKLGTNM YSVNQPVETH VSGSSKNLAS WTQESIAPNP LAKEELNFLA
RLMGGMEIKK PSGPEPGFRL NLFTTDEEEE QAALTRPEEL SYEVINIQAT QDQQRSEELA
RIMGEFEITE QPRLSTSKGD DLLAMMDEL
