ID   OSCP1_MOUSE             Reviewed;         379 AA.
AC   Q8BHW2; Q8BHQ7;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Protein OSCP1;
GN   Name=Oscp1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo, and Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Olfactory epithelium;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=16006562; DOI=10.1074/jbc.m504246200;
RA   Kobayashi Y., Shibusawa A., Saito H., Ohshiro N., Ohbayashi M., Kohyama N.,
RA   Yamamoto T.;
RT   "Isolation and functional characterization of a novel organic solute
RT   carrier protein, hOSCP1.";
RL   J. Biol. Chem. 280:32332-32339(2005).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May be involved in drug clearance in the placenta.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Basal cell membrane {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in testis.
CC       {ECO:0000269|PubMed:16006562}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC36814.1; Type=Frameshift; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK077909; BAC37056.1; -; mRNA.
DR   EMBL; AK077467; BAC36814.1; ALT_FRAME; mRNA.
DR   EMBL; BC045150; AAH45150.1; -; mRNA.
DR   CCDS; CCDS38879.1; -.
DR   RefSeq; NP_766289.2; NM_172701.2.
DR   AlphaFoldDB; Q8BHW2; -.
DR   STRING; 10090.ENSMUSP00000045241; -.
DR   PhosphoSitePlus; Q8BHW2; -.
DR   MaxQB; Q8BHW2; -.
DR   PaxDb; Q8BHW2; -.
DR   PRIDE; Q8BHW2; -.
DR   ProteomicsDB; 295476; -.
DR   Antibodypedia; 31691; 63 antibodies from 19 providers.
DR   Ensembl; ENSMUST00000035497; ENSMUSP00000045241; ENSMUSG00000042616.
DR   GeneID; 230751; -.
DR   KEGG; mmu:230751; -.
DR   UCSC; uc008ush.1; mouse.
DR   CTD; 127700; -.
DR   MGI; MGI:1916308; Oscp1.
DR   VEuPathDB; HostDB:ENSMUSG00000042616; -.
DR   eggNOG; KOG4033; Eukaryota.
DR   GeneTree; ENSGT00390000004808; -.
DR   HOGENOM; CLU_039360_1_0_1; -.
DR   InParanoid; Q8BHW2; -.
DR   OMA; MMVKYQL; -.
DR   OrthoDB; 1398008at2759; -.
DR   PhylomeDB; Q8BHW2; -.
DR   TreeFam; TF105789; -.
DR   BioGRID-ORCS; 230751; 3 hits in 72 CRISPR screens.
DR   ChiTaRS; Oscp1; mouse.
DR   PRO; PR:Q8BHW2; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q8BHW2; protein.
DR   Bgee; ENSMUSG00000042616; Expressed in spermatid and 197 other tissues.
DR   ExpressionAtlas; Q8BHW2; baseline and differential.
DR   Genevisible; Q8BHW2; MM.
DR   GO; GO:0009925; C:basal plasma membrane; ISO:MGI.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; ISO:MGI.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; ISO:MGI.
DR   InterPro; IPR019332; OSCP1.
DR   PANTHER; PTHR21439; PTHR21439; 1.
DR   Pfam; PF10188; Oscp1; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transport.
FT   CHAIN           1..379
FT                   /note="Protein OSCP1"
FT                   /id="PRO_0000251966"
SQ   SEQUENCE   379 AA;  43232 MW;  E0D8719480A9C800 CRC64;
     MSVRTLPLLF LNLGGEMLYV LDQRLRAQNI PGDKARKVLN DIISTMFNRK FMDELFKPQE
     LYSKKALRTV YDRLAHASIM RLNQASMDKL YDLMTMAFKY QVLLCPRPKD VLLVTFNHLD
     AIKGFVQDSP TVIHQVDETF RQLSEVYGKL SEGEFQLIRQ TLLNFFQDLH IRVSTFLKDK
     VQNSNGRFVL PVSGPVPWGT EVPGVIRVFS VKGKEVKKMK FRHGGDYVAA QKEGSFELYG
     DRVLKLGTNM YSASRPVETH MSATSKNAAS RAQENIVPNP LAKEELNFLA RLMGGMEIKK
     PSGPEPGFRL NLFTTDEEEE HAALSRPEEL SYEVISIQAT QDQQRNEELA RIMGEFEITE
     QLEQNTSKGD DLLAMMDRL