ID   OSCRI_HUMAN             Reviewed;         120 AA.
AC   C0HLS1;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 1.
DT   03-AUG-2022, entry version 3.
DE   RecName: Full=SCRIB overlapping open reading frame protein {ECO:0000305|PubMed:34535749};
DE            Short=oSCRIB {ECO:0000303|PubMed:34535749};
GN   Name=SCRIB {ECO:0000303|PubMed:34535749};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION, PROTEIN SEQUENCE OF 53-69 AND 76-93, AND FUNCTION.
RX   PubMed=34535749; DOI=10.1038/s42003-021-02619-8;
RA   Nomura Y., Dohmae N.;
RT   "Discovery of a small protein-encoding cis-regulatory overlapping gene of
RT   the tumor suppressor gene Scribble in humans.";
RL   Commun. Biol. 4:1098-1098(2021).
CC   -!- FUNCTION: Represses translation of the downstream SCRIB protein
CC       (PubMed:34535749). Translation of oSCRIB hinders SCRIB translation but
CC       does not completely abolish it, probably due to leaky scanning which
CC       allows the ribosome to bypass the weaker oSCRIB start codon and
CC       initiate translation at the stronger SCRIB start codon
CC       (PubMed:34535749). {ECO:0000269|PubMed:34535749}.
CC   -!- MISCELLANEOUS: This protein is produced by a polycistronic gene which
CC       also produces the tumor suppressor gene SCRIB from an overlapping
CC       reading frame. {ECO:0000269|PubMed:34535749}.
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DR   EMBL; AC105219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   HGNC; HGNC:30377; SCRIB.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0045947; P:negative regulation of translational initiation; IMP:UniProtKB.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Reference proteome; Translation regulation.
FT   CHAIN           1..120
FT                   /note="SCRIB overlapping open reading frame protein"
FT                   /id="PRO_0000454656"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          86..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   120 AA;  11984 MW;  8F91C24A69B31DBC CRC64;
     MRTEPRPPAP SPPSAAAGAR AAHPHHAQVH PAVALQPARG VGGQAALFAA GRAGGDLPLQ
     PQPGGAAARR QPAARAAQAF FPAAELAQAG PERQRDPAVA SRGGQLHAAG GAGRVPERYP