OSER1_HUMAN
ID OSER1_HUMAN Reviewed; 292 AA.
AC Q9NX31; B2RCK4; O95912; Q9NZ84; Q9P0R8;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2003, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Oxidative stress-responsive serine-rich protein 1;
DE AltName: Full=Oxidative stress-responsive protein 1;
DE AltName: Full=Peroxide-inducible transcript 1 protein;
GN Name=OSER1; Synonyms=C20orf111; ORFNames=BM-038, HSPC168, HSPC207;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow, and Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Stavrides G.S., Huckle E.J., Deloukas P.;
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastric carcinoma, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-233, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF36127.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAF67625.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAA91191.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF161517; AAF29132.1; -; mRNA.
DR EMBL; AF151041; AAF36127.1; ALT_FRAME; mRNA.
DR EMBL; AF217514; AAF67625.1; ALT_FRAME; mRNA.
DR EMBL; AL133000; CAB61348.1; -; mRNA.
DR EMBL; AK000476; BAA91191.1; ALT_FRAME; mRNA.
DR EMBL; AK315155; BAG37601.1; -; mRNA.
DR EMBL; AL035447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW75938.1; -; Genomic_DNA.
DR EMBL; BC064973; AAH64973.1; -; mRNA.
DR CCDS; CCDS13327.1; -.
DR RefSeq; NP_057554.4; NM_016470.7.
DR RefSeq; XP_011527153.1; XM_011528851.1.
DR RefSeq; XP_011527155.1; XM_011528853.2.
DR RefSeq; XP_016883362.1; XM_017027873.1.
DR AlphaFoldDB; Q9NX31; -.
DR SMR; Q9NX31; -.
DR BioGRID; 119588; 13.
DR IntAct; Q9NX31; 10.
DR STRING; 9606.ENSP00000362061; -.
DR iPTMnet; Q9NX31; -.
DR PhosphoSitePlus; Q9NX31; -.
DR BioMuta; OSER1; -.
DR DMDM; 28212214; -.
DR EPD; Q9NX31; -.
DR jPOST; Q9NX31; -.
DR MassIVE; Q9NX31; -.
DR MaxQB; Q9NX31; -.
DR PaxDb; Q9NX31; -.
DR PeptideAtlas; Q9NX31; -.
DR PRIDE; Q9NX31; -.
DR ProteomicsDB; 83026; -.
DR Antibodypedia; 43666; 76 antibodies from 17 providers.
DR DNASU; 51526; -.
DR Ensembl; ENST00000255174.3; ENSP00000255174.2; ENSG00000132823.11.
DR Ensembl; ENST00000372970.6; ENSP00000362061.1; ENSG00000132823.11.
DR GeneID; 51526; -.
DR KEGG; hsa:51526; -.
DR MANE-Select; ENST00000255174.3; ENSP00000255174.2; NM_016470.8; NP_057554.4.
DR UCSC; uc002xlk.4; human.
DR CTD; 51526; -.
DR DisGeNET; 51526; -.
DR GeneCards; OSER1; -.
DR HGNC; HGNC:16105; OSER1.
DR HPA; ENSG00000132823; Low tissue specificity.
DR neXtProt; NX_Q9NX31; -.
DR OpenTargets; ENSG00000132823; -.
DR PharmGKB; PA25651; -.
DR VEuPathDB; HostDB:ENSG00000132823; -.
DR eggNOG; ENOG502QUK0; Eukaryota.
DR GeneTree; ENSGT00390000018547; -.
DR HOGENOM; CLU_050222_0_0_1; -.
DR InParanoid; Q9NX31; -.
DR OMA; ACADKAC; -.
DR OrthoDB; 1164781at2759; -.
DR PhylomeDB; Q9NX31; -.
DR TreeFam; TF331727; -.
DR PathwayCommons; Q9NX31; -.
DR SignaLink; Q9NX31; -.
DR BioGRID-ORCS; 51526; 12 hits in 1046 CRISPR screens.
DR ChiTaRS; OSER1; human.
DR GeneWiki; C20orf111; -.
DR GenomeRNAi; 51526; -.
DR Pharos; Q9NX31; Tdark.
DR PRO; PR:Q9NX31; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9NX31; protein.
DR Bgee; ENSG00000132823; Expressed in left testis and 199 other tissues.
DR Genevisible; Q9NX31; HS.
DR GO; GO:0070301; P:cellular response to hydrogen peroxide; IBA:GO_Central.
DR InterPro; IPR008494; DUF776.
DR PANTHER; PTHR31383; PTHR31383; 1.
DR Pfam; PF05604; DUF776; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..292
FT /note="Oxidative stress-responsive serine-rich protein 1"
FT /id="PRO_0000079453"
FT REGION 24..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..87
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 143
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q703I1"
FT MOD_RES 233
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 74
FT /note="V -> G (in dbSNP:rs9346)"
FT /id="VAR_024333"
SQ SEQUENCE 292 AA; 31779 MW; 4DB0FFBA241FFEF4 CRC64;
MKSEAKDGEE ESLQTAFKKL RVDASGSVAS LSVGEGTGVR APVRTATDDT KPKTTCASKD
SWHGSTRKSS RGAVRTQRRR RSKSPVLHPP KFIHCSTIAS SSSSQLKHKS QTDSPDGSSG
LGISSPKEFS AGESSTSLDA NHTGAVVEPL RTSVPRLPSE SKKEDSSDAT QVPQASLKAS
DLSDFQSVSK LNQGKPCTCI GKECQCKRWH DMEVYSFSGL QSVPPLAPER RSTLEDYSQS
LHARTLSGSP RSCSEQARVF VDDVTIEDLS GYMEYYLYIP KKMSHMAEMM YT
