OSER1_MOUSE
ID OSER1_MOUSE Reviewed; 291 AA.
AC Q9D722; A2A477; Q3U5N3; Q9CXJ2; Q9D9G1;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Oxidative stress-responsive serine-rich protein 1;
DE AltName: Full=Oxidative stress-responsive protein 1;
DE AltName: Full=Peroxide-inducible transcript 1 protein;
GN Name=Oser1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-201.
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Bone marrow, Embryonic head, Testis, Thymus, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK006969; BAB24812.1; -; mRNA.
DR EMBL; AK009708; BAB26453.1; -; mRNA.
DR EMBL; AK014323; BAB29272.1; -; mRNA.
DR EMBL; AK088622; BAC40460.1; -; mRNA.
DR EMBL; AK153499; BAE32045.1; -; mRNA.
DR EMBL; AL589876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC005579; AAH05579.1; -; mRNA.
DR CCDS; CCDS17009.1; -.
DR RefSeq; NP_079975.2; NM_025699.2.
DR RefSeq; XP_006500088.1; XM_006500025.1.
DR RefSeq; XP_006500089.1; XM_006500026.2.
DR AlphaFoldDB; Q9D722; -.
DR STRING; 10090.ENSMUSP00000131932; -.
DR iPTMnet; Q9D722; -.
DR PhosphoSitePlus; Q9D722; -.
DR MaxQB; Q9D722; -.
DR PaxDb; Q9D722; -.
DR PRIDE; Q9D722; -.
DR ProteomicsDB; 294121; -.
DR Antibodypedia; 43666; 76 antibodies from 17 providers.
DR Ensembl; ENSMUST00000046908; ENSMUSP00000039190; ENSMUSG00000035399.
DR Ensembl; ENSMUST00000104954; ENSMUSP00000131932; ENSMUSG00000035399.
DR GeneID; 66680; -.
DR KEGG; mmu:66680; -.
DR UCSC; uc008nsq.2; mouse.
DR CTD; 51526; -.
DR MGI; MGI:1913930; Oser1.
DR VEuPathDB; HostDB:ENSMUSG00000035399; -.
DR eggNOG; ENOG502QUK0; Eukaryota.
DR GeneTree; ENSGT00390000018547; -.
DR HOGENOM; CLU_050222_0_0_1; -.
DR InParanoid; Q9D722; -.
DR OMA; ACADKAC; -.
DR OrthoDB; 1164781at2759; -.
DR PhylomeDB; Q9D722; -.
DR TreeFam; TF331727; -.
DR BioGRID-ORCS; 66680; 6 hits in 71 CRISPR screens.
DR ChiTaRS; Oser1; mouse.
DR PRO; PR:Q9D722; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9D722; protein.
DR Bgee; ENSMUSG00000035399; Expressed in primary oocyte and 62 other tissues.
DR ExpressionAtlas; Q9D722; baseline and differential.
DR Genevisible; Q9D722; MM.
DR GO; GO:0070301; P:cellular response to hydrogen peroxide; ISO:MGI.
DR InterPro; IPR008494; DUF776.
DR PANTHER; PTHR31383; PTHR31383; 1.
DR Pfam; PF05604; DUF776; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..291
FT /note="Oxidative stress-responsive serine-rich protein 1"
FT /id="PRO_0000079454"
FT REGION 29..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..87
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 143
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q703I1"
FT VARIANT 201
FT /note="G -> R (in strain: NOD)"
FT /evidence="ECO:0000269|PubMed:16141072"
FT CONFLICT 67
FT /note="R -> K (in Ref. 1; BAB29272)"
FT /evidence="ECO:0000305"
FT CONFLICT 81
FT /note="R -> A (in Ref. 1; BAB29272)"
FT /evidence="ECO:0000305"
FT CONFLICT 81
FT /note="R -> G (in Ref. 1; BAB24812)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 291 AA; 32011 MW; DDDF55F4645EFC1A CRC64;
MKSEAKDGEE ESLQTAFKKL RVDASGSIIS LSVGEGPSVR ASARTAADDT KPKTMCASKD
SWHGSTRKSS RGAVRTQRRR RSKSPVLHPP KFIHCSTTAP PSSSQLKHRS QTEPPDGISG
RGISTPKEFN AGENSTSLDV NHTGAAIEPL RSSVLRLPSE SKTEELSDAT QVSQESLTAN
DLSDFQSVSK LSQGKPCVCV GKECQCKRWH DMEVYSFSGL QNVPPLAPER RSLEDYSQSL
HTRTLSGSPR SCSEQARVYV DDVTIEDLAG YMEYYLYIPK KMSHMAEMMY T
