OSER1_RAT
ID OSER1_RAT Reviewed; 291 AA.
AC Q703I1;
DT 24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Oxidative stress-responsive serine-rich protein 1;
DE AltName: Full=Oxidative stress-responsive protein 1;
DE AltName: Full=Peroxide-inducible transcript 1 protein;
GN Name=Oser1; Synonyms=Osr1, Perit1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, AND
RP INDUCTION.
RX PubMed=17148688; DOI=10.1152/physiolgenomics.00168.2006;
RA Clerk A., Kemp T.J., Zoumpoulidou G., Sugden P.H.;
RT "Cardiac myocyte gene expression profiling during H2O2-induced apoptosis.";
RL Physiol. Genomics 29:118-127(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-143, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16641100; DOI=10.1073/pnas.0600895103;
RA Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
RT "Quantitative phosphoproteomics of vasopressin-sensitive renal cells:
RT regulation of aquaporin-2 phosphorylation at two sites.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q703I1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q703I1-2; Sequence=VSP_047453;
CC -!- TISSUE SPECIFICITY: [Isoform 1]: Ubiquitous with high level in testis,
CC placenta and cardiac myocytes. {ECO:0000269|PubMed:17148688}.
CC -!- TISSUE SPECIFICITY: [Isoform 2]: Expressed in testis, unpreganant
CC uterus and cardiac myocytes. {ECO:0000269|PubMed:17148688}.
CC -!- INDUCTION: [Isoform 1]: Up-regulated by DNA damaging agents like
CC H(2)O(2) in cardiac myocytes. {ECO:0000269|PubMed:17148688}.
CC -!- INDUCTION: [Isoform 2]: Up-regulated by DNA damaging agents like
CC H(2)O(2) in cardiac myocytes. {ECO:0000269|PubMed:17148688}.
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DR EMBL; AJ621831; CAF21998.1; -; mRNA.
DR EMBL; AABR06027504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH474005; EDL96584.1; -; Genomic_DNA.
DR EMBL; CH474005; EDL96585.1; -; Genomic_DNA.
DR EMBL; BC082096; AAH82096.1; -; mRNA.
DR RefSeq; NP_963854.1; NM_201560.2. [Q703I1-1]
DR RefSeq; XP_006235590.1; XM_006235528.3. [Q703I1-1]
DR RefSeq; XP_017447097.1; XM_017591608.1. [Q703I1-1]
DR AlphaFoldDB; Q703I1; -.
DR STRING; 10116.ENSRNOP00000011610; -.
DR iPTMnet; Q703I1; -.
DR PhosphoSitePlus; Q703I1; -.
DR PaxDb; Q703I1; -.
DR Ensembl; ENSRNOT00000113431; ENSRNOP00000084346; ENSRNOG00000008297. [Q703I1-1]
DR GeneID; 296346; -.
DR KEGG; rno:296346; -.
DR UCSC; RGD:1303142; rat. [Q703I1-1]
DR CTD; 51526; -.
DR RGD; 1303142; Oser1.
DR eggNOG; ENOG502QUK0; Eukaryota.
DR GeneTree; ENSGT00390000018547; -.
DR HOGENOM; CLU_050222_0_0_1; -.
DR InParanoid; Q703I1; -.
DR OMA; ACADKAC; -.
DR OrthoDB; 1164781at2759; -.
DR PhylomeDB; Q703I1; -.
DR TreeFam; TF331727; -.
DR PRO; PR:Q703I1; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Proteomes; UP000234681; Chromosome 3.
DR Bgee; ENSRNOG00000008297; Expressed in testis and 19 other tissues.
DR Genevisible; Q703I1; RN.
DR GO; GO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB.
DR InterPro; IPR008494; DUF776.
DR PANTHER; PTHR31383; PTHR31383; 1.
DR Pfam; PF05604; DUF776; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..291
FT /note="Oxidative stress-responsive serine-rich protein 1"
FT /id="PRO_0000422974"
FT REGION 44..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..87
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 143
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:16641100"
FT VAR_SEQ 60..280
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17148688"
FT /id="VSP_047453"
SQ SEQUENCE 291 AA; 32008 MW; 1FFA4CAD8FAF8A2E CRC64;
MKSEAKDGEE ESLQTAFKKL RVDASGSIVS LSVGEGTSVR ASVRTTVDDT KPKTMCAPKD
SWHGSTRKSS RGAVRIQRRR RSKSPVLHPP KFIHCSTTAS PSSSQLKQRS QTEPLDGSSG
RGISTPKEFS TGENSTSLDI NHTGAAIEPL RSSVLRLPSE SKTEELSDAT QVSPESLTAN
DLSDFQSVSK LSQGKPCVCV GKACQCKRWH DMEVYSFSGL QNVPPLAPER RSLEDYSQSL
HTRTLSGSPR SCSEQARVYV DDVTIEDLAG YMEYYLYIPK KMSHMAEMMY T
