OSG1_CAEEL
ID OSG1_CAEEL Reviewed; 1182 AA.
AC Q21653;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 4.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Rho guanine nucleotide exchange factor osg-1 {ECO:0000303|PubMed:25527286};
DE AltName: Full=Oxidative stress-susceptible GEF1 {ECO:0000312|WormBase:R02F2.2};
GN Name=osg-1 {ECO:0000312|WormBase:R02F2.2};
GN ORFNames=R02F2.2/R02F2.3 {ECO:0000312|WormBase:R02F2.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=25527286; DOI=10.1534/genetics.114.173500;
RA Duan Z., Sesti F.;
RT "Guanine nucleotide exchange factor OSG-1 confers functional aging via
RT dysregulated Rho signaling in Caenorhabditis elegans neurons.";
RL Genetics 199:487-496(2015).
CC -!- FUNCTION: Probable guanine nucleotide exchange factor which regulates
CC the Rho GTPase rho-1. Functions in ASE sensory neurons where it
CC promotes neuronal degeneration under conditions of oxidative stress.
CC {ECO:0000269|PubMed:25527286}.
CC -!- TISSUE SPECIFICITY: Expressed in muscles in the body wall and head, and
CC in the nervous system in neurons including FLP and ASE neurons in the
CC head. {ECO:0000269|PubMed:25527286}.
CC -!- DISRUPTION PHENOTYPE: Viable with normal development, size and
CC lifespan. Reduced sensitivity to factors that induce neurodegeneration.
CC Improved chemosensory response in aging worms.
CC {ECO:0000269|PubMed:25527286}.
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DR EMBL; FO081002; CCD68397.1; -; Genomic_DNA.
DR RefSeq; NP_498172.3; NM_065771.5.
DR AlphaFoldDB; Q21653; -.
DR SMR; Q21653; -.
DR STRING; 6239.R02F2.2; -.
DR EPD; Q21653; -.
DR PaxDb; Q21653; -.
DR PeptideAtlas; Q21653; -.
DR EnsemblMetazoa; R02F2.2.1; R02F2.2.1; WBGene00019832.
DR GeneID; 175756; -.
DR KEGG; cel:CELE_R02F2.2; -.
DR CTD; 175756; -.
DR WormBase; R02F2.2; CE39517; WBGene00019832; osg-1.
DR eggNOG; KOG3522; Eukaryota.
DR GeneTree; ENSGT00940000153798; -.
DR HOGENOM; CLU_001213_2_0_1; -.
DR InParanoid; Q21653; -.
DR OMA; HQNDKCD; -.
DR OrthoDB; 312949at2759; -.
DR PhylomeDB; Q21653; -.
DR Reactome; R-CEL-193648; NRAGE signals death through JNK.
DR Reactome; R-CEL-416482; G alpha (12/13) signalling events.
DR Reactome; R-CEL-8980692; RHOA GTPase cycle.
DR Reactome; R-CEL-9013026; RHOB GTPase cycle.
DR Reactome; R-CEL-9013106; RHOC GTPase cycle.
DR PRO; PR:Q21653; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00019832; Expressed in embryo and 4 other tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IMP:WormBase.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; -; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR039917; ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR PANTHER; PTHR12877; PTHR12877; 1.
DR PANTHER; PTHR12877:SF15; PTHR12877:SF15; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; SSF48065; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Guanine-nucleotide releasing factor; Reference proteome.
FT CHAIN 1..1182
FT /note="Rho guanine nucleotide exchange factor osg-1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000030435"
FT DOMAIN 357..544
FT /note="DH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 863..884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 637..669
FT /evidence="ECO:0000255"
FT COILED 897..922
FT /evidence="ECO:0000255"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1182 AA; 132770 MW; 822ED4D043E9455D CRC64;
MLNPNDADDS DSSTDSSPPV AVPRPKRSAT VSPSTRNSFY NSRRRSDANL NFFNERERQR
ERRRSMVRAS RERSESRRAS QQNLRKTNSE PNVDMPSIDV EALQKLLLSI PKFVSASRNR
INQRHDSDSG GEMTTEIEEL KDAAKSIQSL QRVLAYPSQT SSDRGGNRRL ADPVESCLES
SVFSDVDESS LATDTIEGRR SGISTRLGHP RGVMQFIPSI RNDQFVPTSE IRRNSISRKS
SVPDGFMTSE MESEPVPNVR NRRRGIVDEM FSSSTSLLVD RPSETLAGVN RFAKLLDTFR
SRPTSPEQHP SISWNPYVYS DGGEALETCG MEDSLHEADI LLWKKRSRAS LRRHYSVRHL
AARELLDTEK SFVEGLEFLV TKYMRPLRQP LECTLIEASL VDKIFYRIPE ILAHHQVLLT
TLSQRIDQWH KDAILGDVLL AHFSKQSMIE TYISFVDNFK FAKASIIQAR QKHAFEKYYN
RCCRDHPNKL DLDSLLISPI QRVPRYELIV KQMLKHTPVE HEDRERLLRA QRHIHCLAVA
INQHKDGSEQ MEQRLREIEA IVDGLDDLVT KDRTLLRHDI ITLKGTDRER CIFMLSDLLL
VTSVKKKPKV LYSKMSSQSM GFLEGNRFKL LFKVALEDVQ ISKDTLSQLE EVERKLESSR
EDDRVLKKMS QLCSLLKCER KVLMEMLETM ETSNSMSIRE LNEQMSSDPD LSAVHLDVLT
SNGFEPFVLE FPNAEKRSVF EAMFKDAKAT LAKNLLAAPS CSLKTIIAHQ TRPGLQLCTA
TVVPGKRVDS TPSLWVCASD KFSGQVAVMA LDTGEITIES CSAIGNAAVT AMCTVPPPMK
LRKRKIKSQK SLEHLLNETI MDINSSGSDT ESSSDEGTST AGQTTVWIGN DDGEVFVVNS
TERVRSRARD RLARLRNSIT SICAANGNVL VATSYSNQVQ LLLFRPASDG SWDLENPQTV
GHVCQAPITS MQLIGRRVII ASGNWLHAYF VDTGKFQPPV EILPSSDVIT LMYVTGQNVF
LCGRKSTEVF VVDVFNLSII NHFNVVSFVR SQLSGREHIL REHKMGCLRI SCLTVARSHL
WIGTSAGCVL STSVQSARSQ PTPDLRVCEI GHSGPCRILL PVHTPSHSNH PSRKQKRSSL
NVPAQQSSQL MLVSCGEGLD DGTATQDPST DAINHLIFWK CS
