ID   ASB6_PONAB              Reviewed;         421 AA.
AC   Q5R4M7;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Ankyrin repeat and SOCS box protein 6;
DE            Short=ASB-6;
GN   Name=ASB6;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable substrate-recognition component of a SCF-like ECS
CC       (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC       which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Binds APS. Identified in a complex with ELOB and ELOC.
CC       Interacts with CUL5 and RNF7 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC       complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC       {ECO:0000305}.
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DR   EMBL; CR861219; CAH93289.1; -; mRNA.
DR   RefSeq; NP_001126935.1; NM_001133463.1.
DR   AlphaFoldDB; Q5R4M7; -.
DR   SMR; Q5R4M7; -.
DR   STRING; 9601.ENSPPYP00000022058; -.
DR   GeneID; 100173953; -.
DR   KEGG; pon:100173953; -.
DR   CTD; 140459; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   InParanoid; Q5R4M7; -.
DR   OrthoDB; 668449at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd03725; SOCS_ASB6; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037327; ASB6_SOCS.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00248; ANK; 5.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF158235; SSF158235; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Cytoplasm; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..421
FT                   /note="Ankyrin repeat and SOCS box protein 6"
FT                   /id="PRO_0000285850"
FT   REPEAT          67..97
FT                   /note="ANK 1"
FT   REPEAT          102..131
FT                   /note="ANK 2"
FT   REPEAT          136..166
FT                   /note="ANK 3"
FT   REPEAT          170..205
FT                   /note="ANK 4"
FT   REPEAT          226..255
FT                   /note="ANK 5"
FT   REPEAT          260..289
FT                   /note="ANK 6"
FT   DOMAIN          360..415
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
SQ   SEQUENCE   421 AA;  47212 MW;  7C993FA564B10C97 CRC64;
     MPFLHGFRRI IFEYQPLVDA ILGSLGIQDP ERQESLDRPS YVASEESRIL VLTELLERKA
     HSPFYQEGVS NALLKMAELG LTRAADVLLR HGANLNFEDP VTYYTALHIA VLRNQPDMVE
     LLVHHGADIN RRDRIHESSP LDLASEEPER LPCLQRLLDL GADVNAADKH GKTALLHALA
     SSDGVQIHNT ENIRLLLEGG ADVKATTKDG DTVFTCIIFL LGETVGGDKE EAQMINRFCF
     QVTRLLLAHG ADPSECPAHE SLTHICLKSF KLHFPLLRFL LESGAAYNCS LHGASCWSGF
     HIIFERLCSH PGCTEDESHT DLLRKAETVL DLMVTNSQKL QLPENFDIHP VGSLAEKIQA
     LHFSLRQLES YPPPLKHLCR VAIRLYLQPW PVDVKVKALP LPDRLKWYLL SEHSGSMEDD
     I