ID   OSGI1_MOUSE             Reviewed;         478 AA.
AC   Q8VC10;
DT   03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Oxidative stress-induced growth inhibitor 1 {ECO:0000305};
GN   Name=Osgin1 {ECO:0000312|MGI:MGI:1919089};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Regulates the differentiation and proliferation through the
CC       regulation of cell death. {ECO:0000250|UniProtKB:Q9UJX0}.
CC   -!- SIMILARITY: Belongs to the OKL38 family. {ECO:0000305}.
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DR   EMBL; AC166781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466525; EDL11597.1; -; Genomic_DNA.
DR   EMBL; BC022135; AAH22135.1; -; mRNA.
DR   EMBL; BC132440; AAI32441.1; -; mRNA.
DR   EMBL; BC138192; AAI38193.1; -; mRNA.
DR   CCDS; CCDS22704.1; -.
DR   RefSeq; NP_082226.1; NM_027950.1.
DR   RefSeq; XP_006531440.1; XM_006531377.3.
DR   RefSeq; XP_006531444.1; XM_006531381.3.
DR   AlphaFoldDB; Q8VC10; -.
DR   STRING; 10090.ENSMUSP00000114467; -.
DR   iPTMnet; Q8VC10; -.
DR   PhosphoSitePlus; Q8VC10; -.
DR   MaxQB; Q8VC10; -.
DR   PaxDb; Q8VC10; -.
DR   PRIDE; Q8VC10; -.
DR   ProteomicsDB; 330372; -.
DR   Antibodypedia; 16990; 142 antibodies from 22 providers.
DR   DNASU; 71839; -.
DR   Ensembl; ENSMUST00000152420; ENSMUSP00000114467; ENSMUSG00000074063.
DR   GeneID; 71839; -.
DR   KEGG; mmu:71839; -.
DR   UCSC; uc009npp.1; mouse.
DR   CTD; 29948; -.
DR   MGI; MGI:1919089; Osgin1.
DR   VEuPathDB; HostDB:ENSMUSG00000074063; -.
DR   eggNOG; ENOG502QRUQ; Eukaryota.
DR   GeneTree; ENSGT00390000006658; -.
DR   HOGENOM; CLU_019308_2_0_1; -.
DR   InParanoid; Q8VC10; -.
DR   OMA; ASWDIQT; -.
DR   OrthoDB; 890629at2759; -.
DR   PhylomeDB; Q8VC10; -.
DR   TreeFam; TF313502; -.
DR   BioGRID-ORCS; 71839; 5 hits in 72 CRISPR screens.
DR   PRO; PR:Q8VC10; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q8VC10; protein.
DR   Bgee; ENSMUSG00000074063; Expressed in granulocyte and 143 other tissues.
DR   ExpressionAtlas; Q8VC10; baseline and differential.
DR   GO; GO:0008083; F:growth factor activity; ISO:MGI.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0030308; P:negative regulation of cell growth; ISO:MGI.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:InterPro.
DR   GO; GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR029731; OKL38_fam.
DR   InterPro; IPR029724; OSGIN1.
DR   PANTHER; PTHR15192; PTHR15192; 1.
DR   PANTHER; PTHR15192:SF15; PTHR15192:SF15; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   2: Evidence at transcript level;
KW   Differentiation; Growth regulation; Phosphoprotein; Reference proteome.
FT   CHAIN           1..478
FT                   /note="Oxidative stress-induced growth inhibitor 1"
FT                   /id="PRO_0000447508"
FT   MOD_RES         12
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UJX0"
SQ   SEQUENCE   478 AA;  52170 MW;  0B617024A867F76D CRC64;
     MTSWRHDSLG ASSSEPLPVV IIGNGPSGIC LSYLLSGHIP YVKPGAVHPH PLLQRKLAEA
     PGVSILDQDL EYLSEGLEGR SQSPVALLFD ALLRPDTDFG GSIDSVLSWK RQKDRAVPHL
     VLGRNLPGGA WHSIEGSMVT LSQGQWMSLP DLQVKDWMRK KCRGLRNSRA TAGDIAHYYR
     DYVIKKGLSH NFVSGAVVTA VEWAKSEHGS PEVQASSPLF QVNGYLTTKD HGHQPFSLRA
     RNVVLATGTF DSPAMLGIPG ETLPFVHHDL SALEAALRAG TVNPTSDPVL IVGAGLSAAD
     AVLFARHYNI QVIHAFRRSV HDPGLVFNQL PKMLYPEYHK VQQMMRDQSI LSPSPYEGYR
     SLPEHQPLLF KEDHQAVFQD PQGGQQLFGV SMVLVLIGSH PDLSYLPRAG ADLVIDPDQP
     LSPKRNPIDV DPFTHESTHQ EGLYALGPLA GDNFVRFVQG GALAAASSLL KKETRKPP