OSKA_DROVI
ID OSKA_DROVI Reviewed; 594 AA.
AC Q24741;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Maternal effect protein oskar;
GN Name=osk;
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7925007; DOI=10.1242/dev.120.7.2027;
RA Webster P.J., Suen J., Macdonald P.M.;
RT "Drosophila virilis oskar transgenes direct body patterning but not pole
RT cell formation or maintenance of mRNA localization in D. melanogaster.";
RL Development 120:2027-2037(1994).
CC -!- FUNCTION: Organizes the germ plasm and directs localization of the
CC posterior determinant nanos. Oskar protein is required to keep oskar
CC RNA and staufen protein at the posterior pole (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with smaug (smg). {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Posterior pole of the oocyte.
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DR EMBL; L22556; AAA28426.1; -; Genomic_DNA.
DR AlphaFoldDB; Q24741; -.
DR SMR; Q24741; -.
DR STRING; 7244.FBpp0238207; -.
DR eggNOG; ENOG502SUPD; Eukaryota.
DR GO; GO:0043073; C:germ cell nucleus; IEA:EnsemblMetazoa.
DR GO; GO:0043186; C:P granule; IEA:EnsemblMetazoa.
DR GO; GO:0061803; C:posterior cell cortex; IEA:EnsemblMetazoa.
DR GO; GO:0003729; F:mRNA binding; IEA:EnsemblMetazoa.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:EnsemblMetazoa.
DR GO; GO:0008103; P:oocyte microtubule cytoskeleton polarization; IEA:EnsemblMetazoa.
DR GO; GO:1903863; P:P granule assembly; IEA:EnsemblMetazoa.
DR GO; GO:0007279; P:pole cell formation; IEA:EnsemblMetazoa.
DR GO; GO:0007359; P:posterior abdomen determination; IEA:EnsemblMetazoa.
DR GO; GO:0034504; P:protein localization to nucleus; IEA:EnsemblMetazoa.
DR GO; GO:0043488; P:regulation of mRNA stability; IEA:EnsemblMetazoa.
DR GO; GO:0040040; P:thermosensory behavior; IEA:EnsemblMetazoa.
DR GO; GO:0008542; P:visual learning; IEA:EnsemblMetazoa.
DR Gene3D; 3.30.420.610; -; 1.
DR Gene3D; 3.40.50.1110; -; 1.
DR InterPro; IPR041966; LOTUS-like.
DR InterPro; IPR033447; OSK.
DR InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR Pfam; PF17182; OSK; 1.
DR PROSITE; PS51644; HTH_OST; 1.
PE 2: Evidence at transcript level;
KW Developmental protein.
FT CHAIN 1..594
FT /note="Maternal effect protein oskar"
FT /id="PRO_0000058087"
FT DOMAIN 174..243
FT /note="HTH OST-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT REGION 44..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 594 AA; 68823 MW; 176B4D4246FE475C CRC64;
MATFRSEFNS VPNTYNQRLT ALKKKLTTCF QQWRQQLLKL HQQQQQPKQQ QQQQQHQSQH
QHQQQKQKQR GSEHFYNIFV RADCSILSEK VTYLRKFKRI FTARQNLASA RTAATAASAK
QPVLGRCIGQ EEQQLQIVAS LFSSTLISKH SSSASITSSS MTIMDNTYIG VRDEYPDIDT
EIRSILLANA QNGITISSIK KEYRQLTGTA FPLHDNITDF LLTIPHVTAE CCESGKRIFN
IKPTEHTRHL HEMILQQRQR DSVSNPIQAQ EPPRLWRAQY KRRIPQHFNF NLNTSEKPPA
VKISKLQPLA TAAAMSNDVY QDNWKHLNNQ YQLPQLNAPK NNIHSHIASN PAQLQAALPA
EHHPSKHVEE YAHKRRHEYT RTPTTLSCPS TQHDSMFTIN SDYDAYLLDF PLLGDDFFLY
LARMELKCRF KKFEKVLQSG LCISGQTINA ARQRLRLVEL PEMTQIIVNI GSEDIMRGRS
LVQIEHDFRL LVKEMHNRRF VPVLTTLAPL ANCRHDKQTC DKVSRFNKFI RSEGRHLKVI
DIHSCLINEN GIVRFDCFQN GPRSVTGSSE PYVFWNKIGR QRVLHMIEEN LEYY
