OSM11_CAEEL
ID OSM11_CAEEL Reviewed; 189 AA.
AC O45346;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Notch ligand osm-11 {ECO:0000303|PubMed:18700817};
DE AltName: Full=Osmotic avoidance abnormal protein 11 {ECO:0000312|WormBase:F11C7.5};
DE Flags: Precursor;
GN Name=osm-11 {ECO:0000312|WormBase:F11C7.5};
GN ORFNames=F11C7.5 {ECO:0000312|WormBase:F11C7.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, INTERACTION WITH LIN-12, SUBCELLULAR LOCATION, DEVELOPMENTAL
RP STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=18700817; DOI=10.1371/journal.pbio.0060196;
RA Komatsu H., Chao M.Y., Larkins-Ford J., Corkins M.E., Somers G.A.,
RA Tucey T., Dionne H.M., White J.Q., Wani K., Boxem M., Hart A.C.;
RT "OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans
RT vulval development.";
RL PLoS Biol. 6:e196-e196(2008).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=21549604; DOI=10.1016/j.cub.2011.04.010;
RA Singh K., Chao M.Y., Somers G.A., Komatsu H., Corkins M.E.,
RA Larkins-Ford J., Tucey T., Dionne H.M., Walsh M.B., Beaumont E.K.,
RA Hart D.P., Lockery S.R., Hart A.C.;
RT "C. elegans Notch signaling regulates adult chemosensory response and
RT larval molting quiescence.";
RL Curr. Biol. 21:825-834(2011).
CC -!- FUNCTION: Probable secreted lin-12/Notch ligand or co-ligand involved
CC in the mediation of Notch signaling (PubMed:18700817, PubMed:21549604).
CC Involved in the lin-12/Notch pathway signaling of cell fate in vulval
CC precursor cells (VPCs), acting redundantly with dsl-1 and lag-2
CC (PubMed:18700817). Required for normal octanol avoidance response,
CC acting via both lin-12/Notch and glp-1/Notch signaling pathways in
CC neurons, in concert with lag-2 (PubMed:21549604). Involved in
CC regulation of sleep-like quiescence during the larval to adult
CC transition, acting via Notch receptor activation and in parallel with
CC EGF signaling (PubMed:21549604). {ECO:0000269|PubMed:18700817,
CC ECO:0000269|PubMed:21549604}.
CC -!- SUBUNIT: May interact with lin-12/Notch receptor.
CC {ECO:0000269|PubMed:18700817}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000269|PubMed:18700817}; Peripheral membrane protein
CC {ECO:0000269|PubMed:18700817}. Note=Concentrated on the apical surface
CC of vulval precursor cells. {ECO:0000269|PubMed:18700817}.
CC -!- TISSUE SPECIFICITY: Expressed in coelomocytes (at protein level).
CC {ECO:0000269|PubMed:21549604}.
CC -!- DEVELOPMENTAL STAGE: Expressed in VPCs and hypodermal cells during
CC larval development (PubMed:18700817). Expressed in VPCs of L3 stage
CC larvae prior to and during cell fate specification and in the seam
CC cells of L1 stage larvae and adult animals (at protein level)
CC (PubMed:18700817). Expressed in developing uterus of L4 stage larvae
CC and in the spermatheca (at protein level) (PubMed:18700817).
CC {ECO:0000269|PubMed:18700817}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown causes moderately
CC abnormal vulval development (PubMed:18700817). RNAi-mediated knockdown
CC causes defects in octanol response (PubMed:21549604).
CC {ECO:0000269|PubMed:18700817, ECO:0000269|PubMed:21549604}.
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DR EMBL; BX284606; CCD66914.1; -; Genomic_DNA.
DR PIR; F89753; F89753.
DR RefSeq; NP_510823.1; NM_078422.5.
DR AlphaFoldDB; O45346; -.
DR DIP; DIP-46050N; -.
DR IntAct; O45346; 2.
DR STRING; 6239.F11C7.5; -.
DR EPD; O45346; -.
DR PaxDb; O45346; -.
DR PeptideAtlas; O45346; -.
DR EnsemblMetazoa; F11C7.5.1; F11C7.5.1; WBGene00003891.
DR EnsemblMetazoa; F11C7.5.2; F11C7.5.2; WBGene00003891.
DR GeneID; 181772; -.
DR KEGG; cel:CELE_F11C7.5; -.
DR UCSC; F11C7.5; c. elegans.
DR CTD; 181772; -.
DR WormBase; F11C7.5; CE17657; WBGene00003891; osm-11.
DR eggNOG; ENOG502TFHE; Eukaryota.
DR HOGENOM; CLU_1429188_0_0_1; -.
DR InParanoid; O45346; -.
DR OMA; KFCPAYE; -.
DR OrthoDB; 1318528at2759; -.
DR PhylomeDB; O45346; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00003891; Expressed in adult organism and 4 other tissues.
DR GO; GO:0045177; C:apical part of cell; IDA:WormBase.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IDA:WormBase.
DR GO; GO:0005112; F:Notch binding; IPI:WormBase.
DR GO; GO:0001708; P:cell fate specification; IMP:WormBase.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IGI:WormBase.
DR GO; GO:0006970; P:response to osmotic stress; IMP:WormBase.
DR GO; GO:0040025; P:vulval development; IMP:WormBase.
PE 1: Evidence at protein level;
KW Cell membrane; Developmental protein; Membrane; Notch signaling pathway;
KW Reference proteome; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..189
FT /note="Notch ligand osm-11"
FT /evidence="ECO:0000255"
FT /id="PRO_5004158500"
SQ SEQUENCE 189 AA; 20729 MW; 5E1161004C597334 CRC64;
MNFITVAALA IVMVLAQANP ARVRRNEEMS ERYCIKHLDH YNKYCGDNAG PIDRALFGKV
AKFCPAYEKH CAVGKAGLVE LPDLGSPLVM PPVLPRGSDF ASLDLPIADE RKPAHIHSSR
TAPQTTRLTA AIVATCTPEC TAAHCTDECK CAHTHPKVHQ MCNPPSSAAM AETCQRWYSK
CTMFTPVQY
