OSM1_DROME
ID OSM1_DROME Reviewed; 1754 AA.
AC Q9W040;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-MAY-2014, sequence version 3.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Intraflagellar transport protein 172 homolog {ECO:0000250|UniProtKB:Q5DM57};
DE AltName: Full=Osmotic avoidance abnormal protein 1 homolog;
DE AltName: Full=Outer segment 2;
GN Name=Oseg2 {ECO:0000312|FlyBase:FBgn0035317}; Synonyms=osm-1;
GN ORFNames=CG13809 {ECO:0000312|FlyBase:FBgn0035317};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Required for the maintenance and formation of cilia.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IFT172 family. {ECO:0000305}.
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DR EMBL; AE014296; AAF47619.3; -; Genomic_DNA.
DR RefSeq; NP_647700.2; NM_139443.2.
DR AlphaFoldDB; Q9W040; -.
DR BioGRID; 63798; 2.
DR IntAct; Q9W040; 7.
DR STRING; 7227.FBpp0304907; -.
DR PaxDb; Q9W040; -.
DR PRIDE; Q9W040; -.
DR EnsemblMetazoa; FBtr0332661; FBpp0304907; FBgn0035317.
DR GeneID; 38282; -.
DR KEGG; dme:Dmel_CG13809; -.
DR CTD; 38282; -.
DR FlyBase; FBgn0035317; Oseg2.
DR VEuPathDB; VectorBase:FBgn0035317; -.
DR eggNOG; KOG3616; Eukaryota.
DR GeneTree; ENSGT00940000153417; -.
DR HOGENOM; CLU_002716_0_0_1; -.
DR InParanoid; Q9W040; -.
DR OMA; YQQLGMW; -.
DR OrthoDB; 30851at2759; -.
DR PhylomeDB; Q9W040; -.
DR Reactome; R-DME-5610787; Hedgehog 'off' state.
DR Reactome; R-DME-5620924; Intraflagellar transport.
DR SignaLink; Q9W040; -.
DR BioGRID-ORCS; 38282; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 38282; -.
DR PRO; PR:Q9W040; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0035317; Expressed in antenna and 2 other tissues.
DR Genevisible; Q9W040; DM.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0030990; C:intraciliary transport particle; ISS:FlyBase.
DR GO; GO:0030992; C:intraciliary transport particle B; IBA:GO_Central.
DR GO; GO:0097730; C:non-motile cilium; IDA:FlyBase.
DR GO; GO:0060271; P:cilium assembly; IEP:FlyBase.
DR GO; GO:0042073; P:intraciliary transport; IMP:FlyBase.
DR GO; GO:1905515; P:non-motile cilium assembly; IMP:FlyBase.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 3: Inferred from homology;
KW Cell projection; Cilium; Developmental protein; Reference proteome; Repeat;
KW TPR repeat; WD repeat.
FT CHAIN 1..1754
FT /note="Intraflagellar transport protein 172 homolog"
FT /id="PRO_0000328946"
FT REPEAT 14..53
FT /note="WD 1"
FT REPEAT 64..103
FT /note="WD 2"
FT REPEAT 110..149
FT /note="WD 3"
FT REPEAT 151..190
FT /note="WD 4"
FT REPEAT 194..232
FT /note="WD 5"
FT REPEAT 283..322
FT /note="WD 6"
FT REPEAT 519..557
FT /note="WD 7"
FT REPEAT 623..656
FT /note="TPR 1"
FT REPEAT 690..723
FT /note="TPR 2"
FT REPEAT 748..781
FT /note="TPR 3"
FT REPEAT 807..840
FT /note="TPR 4"
FT REPEAT 852..885
FT /note="TPR 5"
FT REPEAT 1041..1074
FT /note="TPR 6"
FT REPEAT 1140..1166
FT /note="TPR 7"
FT REPEAT 1167..1199
FT /note="TPR 8"
FT REPEAT 1211..1250
FT /note="TPR 9"
FT REPEAT 1282..1315
FT /note="TPR 10"
FT REPEAT 1698..1733
FT /note="TPR 11"
SQ SEQUENCE 1754 AA; 195708 MW; 673CE3C889A0C50B CRC64;
MQLKYLRTLL EGQEQIQRIA GLAWSPNQQR LAIATADRHI LLYDDAGERR DKFSTKPANP
ANGKNSYVIR GLAFSPDSTK LAVGQSDSIV YVYKLGESWN DKKVICNKFP QASAVTALIW
LTSGSIIAGL EDGKVRALHS KSNKSQSLYG GDSICISLAA NTKGTGFLSG HNDGTIIRYF
MTDEATEPLG RVVQHPVPPF ALAWPQGGFC AGGCDQRIVF YDSMGRQLRT FDHSRTEGER
EFTVAACSPN GQAVAFGSFD RIRIFAWSPR QGAWSESATK EVACLYTLSS LLWRRDGARL
ALGSVSGAVL LFESVLRRTV WQDKFELIFV APSQLLVRSL TEPSQALTIE SQLGLEIDDV
RIMGRDNYLV ARTEESLILC DLTRNLSSEV PWTASGHHER FYFENPTVCL IFNVGELSLV
EYGENSILGS VRTEFVNPHV ISVRLNERGN AKENKKLAFL LDAKTICVVD LISRMTSGQI
SHETKIDWLE LSETAHKLLF RDKKLRLILV DNYTGKKQTL LSNISFVQWV PQSDVVVAQS
NSNLAIWYNI DLPEHVTMQS VRGEAIEVLR ENGRTVVRSQ DGPSEHNYQL DEGLVEFGTA
VNDSDFGRAV HFLESLGDKP AAKAMWHNLA LIALEDGNLR VAQRCYAALG NVSKAYYLAG
MIQQADEFEE SSGSPGILCP EVRAKLALLG SDLRTAERIY LEQGDIESAL KMYQQLGMWD
EAVALAERRG YNRIAELKQQ HMDYLLSSEQ QEKAGQVLEE QGDLQQAMSL YMKANKPARA
ARLALKTPHI LQDEQVMLQV TEGLVRSELY ELAGDIAHRL SRPEAALALY RKGGAYARAL
EIGRVVAPQE VTALEEEWGD WLVSRKQLDA SINHYIEAGA TQKALEAAVG AKQWRKAVQI
AKVLDEPELI QRYAVDLAKH LAFAGDLDGA EDMLVRANLH KDAIELLNRH GKWERAYLIG
EKHLKAEQVR ELFVQLAGTL EEQGKFRDAE KVLIAVNEPD LAIAMYKRRE LYDSMIRLVE
RYHKDLLDST HLHLARQLES RGKLKNAEMH FVASGDWKSA VHMYCSSGRW EDGYRVAKLK
GTEGASQQVA YMWAKSMPTE GAVRLLSKLG LLDTAVGFAC DSGQFEFAME LCKFAGKPTD
EVHLKIAMSL EDEGKFEAAE AEFLKANKPR EAILMYQHAG DWQAALNVAE NHLPDAVGEV
LIGQASAALE TSNYKDYEAL LLRAHRPDLI IEHYKQESLY EDALRIAEEH YPSALNDLRR
LQAQLQRGQA QAQAGEDAAS ISRSYLQKAA EFAKKEQFRK AAECLMQIDS SNAEDASTLE
RALLRAAEIC NQFLEGQDAQ ELAQSLGPRL LAIKQIGPAA QLYLAADMPK QAVDVFIKTE
QWSKARRLAK EIDPDLQLLA YVEQQQKASL KHEGNIEQLA DIDIVSALDL LAEHGEWQRC
LEKAKGLNPA LLQKYVAVYA AQLIREGNCT TALGLYLSYG APPIEAHFNI YTRIALDCLA
LREEQTERGT TWRQLRDFLF RLLQSLKATP AQSQTKFAAS MEQFLLIAHY YATRAACKEV
QALQPVALRL SLALLRHTDL LPVDKGFYEA GMDLRQAGRE AEAFVMLNHY LDVCEAIEEG
SGQLVDHSDL ASTDFPSSVP LPEDIHLKND PSLHEEVREW VLAVSMDQQV DQQLPTDDRG
LYESSLGPND LPCMLSGFPV RGRQPVTFQG SSNQVNRDVW SKFSVALKMS PGSGIADIIS
FTEKWQGAAN YVMH
