ASB7_MOUSE
ID ASB7_MOUSE Reviewed; 318 AA.
AC Q91ZU0; G3UVX4;
DT 28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Ankyrin repeat and SOCS box protein 7;
DE Short=ASB-7;
GN Name=Asb7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11509662; DOI=10.1128/mcb.21.18.6189-6197.2001;
RA Kile B.T., Metcalf D., Mifsud S., DiRago L., Nicola N.A., Hilton D.J.,
RA Alexander W.S.;
RT "Functional analysis of Asb-1 using genetic modification in mice.";
RL Mol. Cell. Biol. 21:6189-6197(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Interacts with CUL5 and RNF7. {ECO:0000250}.
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000305}.
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DR EMBL; AF398968; AAK97490.1; -; mRNA.
DR EMBL; AC115761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC120791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466543; EDL07214.1; -; Genomic_DNA.
DR CCDS; CCDS21346.1; -.
DR RefSeq; NP_536691.2; NM_080443.2.
DR RefSeq; XP_006540630.1; XM_006540567.3.
DR AlphaFoldDB; Q91ZU0; -.
DR SMR; Q91ZU0; -.
DR STRING; 10090.ENSMUSP00000122395; -.
DR iPTMnet; Q91ZU0; -.
DR PhosphoSitePlus; Q91ZU0; -.
DR PaxDb; Q91ZU0; -.
DR PRIDE; Q91ZU0; -.
DR ProteomicsDB; 277252; -.
DR Antibodypedia; 1147; 154 antibodies from 19 providers.
DR Ensembl; ENSMUST00000124899; ENSMUSP00000122395; ENSMUSG00000030509.
DR GeneID; 117589; -.
DR KEGG; mmu:117589; -.
DR UCSC; uc009hhn.3; mouse.
DR CTD; 140460; -.
DR MGI; MGI:2152835; Asb7.
DR VEuPathDB; HostDB:ENSMUSG00000030509; -.
DR eggNOG; KOG4177; Eukaryota.
DR GeneTree; ENSGT00940000158068; -.
DR HOGENOM; CLU_084795_0_0_1; -.
DR InParanoid; Q91ZU0; -.
DR OMA; CNGWTLL; -.
DR OrthoDB; 1514637at2759; -.
DR PhylomeDB; Q91ZU0; -.
DR TreeFam; TF331695; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 117589; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Asb7; mouse.
DR PRO; PR:Q91ZU0; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q91ZU0; protein.
DR Bgee; ENSMUSG00000030509; Expressed in granulocyte and 216 other tissues.
DR ExpressionAtlas; Q91ZU0; baseline and differential.
DR Genevisible; Q91ZU0; MM.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03726; SOCS_ASB7; 1.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037326; ASB7_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 7.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF158235; SSF158235; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..318
FT /note="Ankyrin repeat and SOCS box protein 7"
FT /id="PRO_0000066937"
FT REPEAT 13..42
FT /note="ANK 1"
FT REPEAT 46..75
FT /note="ANK 2"
FT REPEAT 80..109
FT /note="ANK 3"
FT REPEAT 116..145
FT /note="ANK 4"
FT REPEAT 149..178
FT /note="ANK 5"
FT REPEAT 180..208
FT /note="ANK 6"
FT REPEAT 213..242
FT /note="ANK 7"
FT DOMAIN 265..318
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT CONFLICT 273
FT /note="R -> S (in Ref. 1; AAK97490)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 318 AA; 35984 MW; F725AF4F350DF83E CRC64;
MLHHHCRRNP ELQEELQIQA AVAAGDVHTV RKMLEQGYSP NGRDANGWTL LHFSAARGKE
RCVRVFLEHG ADPTVKDLIG GFTALHYAAM HGRARIARLM LESEYRSDII NAKSNDGWTP
LHVAAHYGRD SFVRLLLEFK AEVDPLSDKG TTPLQLAIIR ERSSCVKILL DHNANIDIQN
GFLLRYAVIK SNHSYCRMFL QRGADTNLGR LEDGQTPLHL SALRDDVLCA RMLYNYGADT
NTRNYEGQTP LAVSISISGS SRPCLDFLQD VTRQPRTLQD LCRIKIRQCI GLQNLKLLDE
LPIAKVMKDY LKHKFDDI
