OSM8_CAEEL
ID OSM8_CAEEL Reviewed; 331 AA.
AC Q09423;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 09-JUL-2014, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Osmotic avoidance abnormal protein 8;
DE Flags: Precursor;
GN Name=osm-8; ORFNames=R07G3.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=21253570; DOI=10.1371/journal.pgen.1001267;
RA Rohlfing A.K., Miteva Y., Moronetti L., He L., Lamitina T.;
RT "The Caenorhabditis elegans mucin-like protein OSM-8 negatively regulates
RT osmosensitive physiology via the transmembrane protein PTR-23.";
RL PLoS Genet. 7:E1001267-E1001267(2011).
CC -!- FUNCTION: Negative regulator of the osmotic stress response. Acts via
CC the transmembrane protein ptr-23. {ECO:0000269|PubMed:21253570}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21253570}.
CC -!- TISSUE SPECIFICITY: Expressed in the hypodermal syncitium but not in
CC hypodermal seam cells. {ECO:0000269|PubMed:21253570}.
CC -!- DEVELOPMENTAL STAGE: Expressed during larval development and strongly
CC down-regulated in adults. {ECO:0000269|PubMed:21253570}.
CC -!- DISRUPTION PHENOTYPE: Normal physiological responses to hypertonic
CC stress, such as accumulation of organic osmolytes and activation of
CC osmoresponsive genes, are constitutively activated with mutants
CC exhibiting resistance to normally lethal levels of hypertonic stress.
CC {ECO:0000269|PubMed:21253570}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CCD70517.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; FO081291; CCD70517.1; ALT_SEQ; Genomic_DNA.
DR PIR; T16704; T16704.
DR RefSeq; NP_495595.2; NM_063194.6.
DR AlphaFoldDB; Q09423; -.
DR STRING; 6239.R07G3.6; -.
DR EPD; Q09423; -.
DR PaxDb; Q09423; -.
DR PeptideAtlas; Q09423; -.
DR PRIDE; Q09423; -.
DR EnsemblMetazoa; R07G3.6.1; R07G3.6.1; WBGene00003888.
DR GeneID; 187684; -.
DR KEGG; cel:CELE_R07G3.6; -.
DR UCSC; R07G3.6; c. elegans.
DR CTD; 187684; -.
DR WormBase; R07G3.6; CE50739; WBGene00003888; osm-8.
DR eggNOG; ENOG502TFRG; Eukaryota.
DR HOGENOM; CLU_915973_0_0_1; -.
DR InParanoid; Q09423; -.
DR OMA; PQFKLQD; -.
DR OrthoDB; 1038947at2759; -.
DR PRO; PR:Q09423; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00003888; Expressed in embryo and 4 other tissues.
DR GO; GO:0005615; C:extracellular space; IMP:UniProtKB.
DR GO; GO:0006970; P:response to osmotic stress; IMP:UniProtKB.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal; Stress response.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..331
FT /note="Osmotic avoidance abnormal protein 8"
FT /id="PRO_0000065426"
SQ SEQUENCE 331 AA; 37994 MW; 9A96CD3170A4570A CRC64;
MPAKMLKWLL IHIFLIHSIF CQDAPAQMPF FANSDPMMSK LSQIQFADAP TLKGDKYPDV
DAHRIIAPII SPIMEVFDQM KENQRARDQA EKIRKDREDH PLSTSRSLWE MFQRLQRPTT
TTTEAPPLIE RLFKPYIEPW QKQLDDFSKD MAGITLIPTT TTTPAPTTTT TPNFLEKSLS
MFFPSLRRKP QSIPTLPPTT TPTPRLFDPE MFDRLFFKRD KRQATIAPAP KFDIFTVPPP
PPLFQEWEKP ILSLSNPFTL NPLMKMFTTP SPPQTLAPLP KIPEPNPYEI KKGLPEPQFK
LQDPFYNPLF PSRKSKMFDF LAGGEAGRLL G
