OSMW_SALTY
ID OSMW_SALTY Reviewed; 215 AA.
AC Q8ZPK3;
DT 03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Osmoprotectant import permease protein OsmW;
GN Name=osmW; OrderedLocusNames=STM1492;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2]
RP FUNCTION, SUBUNIT, INDUCTION, DISRUPTION PHENOTYPE, AND GENE NAME.
RC STRAIN=LT2;
RX PubMed=22609924; DOI=10.1128/jb.00495-12;
RA Frossard S.M., Khan A.A., Warrick E.C., Gately J.M., Hanson A.D.,
RA Oldham M.L., Sanders D.A., Csonka L.N.;
RT "Identification of a third osmoprotectant transport system, the osmU
RT system, in Salmonella enterica.";
RL J. Bacteriol. 194:3861-3871(2012).
CC -!- FUNCTION: Part of the OsmU ABC transporter complex, which is involved
CC in the uptake of osmoprotectants such as choline-O-sulfate and glycine
CC betaine. Probably responsible for the translocation of the substrate
CC across the membrane. {ECO:0000269|PubMed:22609924}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (OsmV),
CC two transmembrane proteins (OsmW and OsmY) and a solute-binding protein
CC (OsmX). {ECO:0000305|PubMed:22609924}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- INDUCTION: Induced by osmotic stress. Part of the osmU operon, which
CC consists of four genes (osmV, osmW, osmX and osmY).
CC {ECO:0000269|PubMed:22609924}.
CC -!- DISRUPTION PHENOTYPE: Deletion of the osmU operon eliminates the
CC residual osmoprotection by glycine betaine in a mutant that is lacking
CC the ProP and the ProU systems. OsmU deletion has no effect on the
CC utilization of glycine betaine as an osmoprotectant when ProP or ProU
CC are functional. {ECO:0000269|PubMed:22609924}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000305}.
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DR EMBL; AE006468; AAL20411.1; -; Genomic_DNA.
DR RefSeq; NP_460452.1; NC_003197.2.
DR RefSeq; WP_000379677.1; NC_003197.2.
DR AlphaFoldDB; Q8ZPK3; -.
DR SMR; Q8ZPK3; -.
DR STRING; 99287.STM1492; -.
DR TCDB; 3.A.1.12.14; the atp-binding cassette (abc) superfamily.
DR PaxDb; Q8ZPK3; -.
DR EnsemblBacteria; AAL20411; AAL20411; STM1492.
DR GeneID; 1253010; -.
DR KEGG; stm:STM1492; -.
DR PATRIC; fig|99287.12.peg.1577; -.
DR HOGENOM; CLU_046113_7_2_6; -.
DR OMA; NMGQATP; -.
DR PhylomeDB; Q8ZPK3; -.
DR BioCyc; SENT99287:STM1492-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..215
FT /note="Osmoprotectant import permease protein OsmW"
FT /id="PRO_0000430044"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 51..73
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 78..100
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 18..202
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 215 AA; 22883 MW; CBBE7E8FFF5C77AF CRC64;
MDTIHYMLDN AGYLASLTFQ HLWLVALAVG LAIIIGVPLG VLIVRHKWLA TPVLGAATLL
LTIPSIALFG LMIPLFSLIG HGIGVLPAVT AVFLYSLLPI VRNTHTALDS LPPGLREAGR
GIGMTFWQRL RWVEIPMALP VIFGGIRTAV VMNIGVMAIA AVIGAGGLGL LLLNGISGSD
IRMLIAGALM ICLLAIVLDW LLHRLQVVLT PKGIR
