ID   ASB8_BOVIN              Reviewed;         288 AA.
AC   Q08E43;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Ankyrin repeat and SOCS box protein 8;
DE            Short=ASB-8;
GN   Name=ASB8;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC       (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC       which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC       complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC       {ECO:0000305}.
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DR   EMBL; BC123430; AAI23431.1; -; mRNA.
DR   RefSeq; NP_001069920.1; NM_001076452.1.
DR   RefSeq; XP_005206461.1; XM_005206404.3.
DR   RefSeq; XP_005206463.1; XM_005206406.3.
DR   AlphaFoldDB; Q08E43; -.
DR   SMR; Q08E43; -.
DR   STRING; 9913.ENSBTAP00000000361; -.
DR   PaxDb; Q08E43; -.
DR   PRIDE; Q08E43; -.
DR   Ensembl; ENSBTAT00000000361; ENSBTAP00000000361; ENSBTAG00000000289.
DR   GeneID; 617269; -.
DR   KEGG; bta:617269; -.
DR   CTD; 140461; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000289; -.
DR   VGNC; VGNC:26201; ASB8.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000159366; -.
DR   HOGENOM; CLU_000134_52_0_1; -.
DR   InParanoid; Q08E43; -.
DR   OMA; DDTPLSW; -.
DR   OrthoDB; 896829at2759; -.
DR   TreeFam; TF332452; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000000289; Expressed in semen and 104 other tissues.
DR   ExpressionAtlas; Q08E43; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd03727; SOCS_ASB8; 1.
DR   Gene3D; 1.25.40.20; -; 3.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037332; ASB8_SOCS.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00248; ANK; 4.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF158235; SSF158235; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Cytoplasm; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..288
FT                   /note="Ankyrin repeat and SOCS box protein 8"
FT                   /id="PRO_0000283058"
FT   REPEAT          52..81
FT                   /note="ANK 1"
FT   REPEAT          85..113
FT                   /note="ANK 2"
FT   REPEAT          117..146
FT                   /note="ANK 3"
FT   REPEAT          150..179
FT                   /note="ANK 4"
FT   DOMAIN          235..288
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
SQ   SEQUENCE   288 AA;  31676 MW;  30F27F7B9829FAB0 CRC64;
     MSSSMWYIMQ SIQSKYSLSE RLIRTIAAIR SFPHDNVEDL IRGGADVNCT HGTLKPLHCA
     CMVSDADCVE LLLEKGAEVN ALDGYNRTAL HYAAEKDEAC VEVLLEYGAN PNALDGNRDT
     PLHWAAFKNN AECVRALLES GASVNALDYN NDTPLSWAAM KGNLESVSIL LDYGAEVRVI
     NLKGQTPISR LVALLVRGLG TEKEDSCFEL LHRAVGHFEL RKNGTMPREV AKDQQLCEKL
     TVLCSAPGTL KTLSRYAVRR SLGLQYLPDA VKGLPLPASL KEYLLLIE