ID   OSM_OSMRU               Reviewed;          17 AA.
AC   P0CD70;
DT   09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Osmin;
OS   Osmia rufa (Red mason bee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC   Megachilidae; Megachilinae; Osmia.
OX   NCBI_TaxID=1437190;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, FUNCTION, AMIDATION AT VAL-17, AND
RP   SYNTHESIS.
RC   TISSUE=Venom;
RX   PubMed=19109988; DOI=10.1016/j.toxicon.2008.12.011;
RA   Stocklin R., Favreau P., Thai R., Pflugfelder J., Bulet P., Mebs D.;
RT   "Structural identification by mass spectrometry of a novel antimicrobial
RT   peptide from the venom of the solitary bee Osmia rufa (hymenoptera:
RT   megachilidae).";
RL   Toxicon 55:20-27(2010).
CC   -!- FUNCTION: Synthetic peptide exhibits hemolytic activities (less than
CC       melittin) and inhibits bacterial (M.luteus and E.coli) and fungal
CC       (F.oxysporum) growth at micromolar concentrations. A synthetic peptide
CC       with a free C-terminus shows weaker hemolytic, antibacterial and
CC       antifungal activities. {ECO:0000269|PubMed:19109988}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MASS SPECTROMETRY: Mass=1924.20; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:19109988};
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DR   AlphaFoldDB; P0CD70; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing;
KW   Fungicide; Hemolysis; Secreted; Toxin.
FT   PEPTIDE         1..17
FT                   /note="Osmin"
FT                   /id="PRO_0000391364"
FT   MOD_RES         17
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000269|PubMed:19109988"
SQ   SEQUENCE   17 AA;  1926 MW;  84184CCE1E83C64D CRC64;
     GFLSALKKYL PIVLKHV