ID   OSPA6_BORBG             Reviewed;         273 AA.
AC   P0A3N6; Q09088;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Outer surface protein A;
DE   Flags: Precursor;
GN   Name=ospA;
OS   Borreliella burgdorferi (Lyme disease spirochete) (Borrelia burgdorferi).
OG   Plasmid lp54.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=139;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PKo;
RX   PubMed=8432821; DOI=10.1128/jcm.31.2.340-350.1993;
RA   Zumstein G., Fuchs R., Hofmann A., Preac-Mursic V., Soutschek E.,
RA   Wilske B.;
RT   "An OspA serotyping system for Borrelia burgdorferi based on reactivity
RT   with monoclonal antibodies and OspA sequence analysis.";
RL   J. Clin. Microbiol. 31:340-350(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PKo;
RX   PubMed=1560779; DOI=10.1111/j.1365-2958.1992.tb01495.x;
RA   Fuchs R., Jauris S., Lottspeich F., Preac-Mursic V., Wilske B.,
RA   Soutschek E.;
RT   "Molecular analysis and expression of a Borrelia burgdorferi gene encoding
RT   a 22 kDa protein (pC) in Escherichia coli.";
RL   Mol. Microbiol. 6:503-509(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PBo, PWudl, and PWudl/6;
RX   PubMed=7500914; DOI=10.1007/bf00221390;
RA   Will G., Jauris-Heipke S., Schwab E., Busch U., Roessler D., Soutschek E.,
RA   Wilske B., Preac-Mursic V.;
RT   "Sequence analysis of ospA genes shows homogeneity within Borrelia
RT   burgdorferi sensu stricto and Borrelia afzelii strains but reveals major
RT   subgroups within the Borrelia garinii species.";
RL   Med. Microbiol. Immunol. 184:73-80(1995).
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Lipid-anchor.
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DR   EMBL; S48322; AAB23809.1; -; Genomic_DNA.
DR   EMBL; X62161; CAA44092.1; -; Genomic_DNA.
DR   EMBL; X80183; CAA56468.1; -; Genomic_DNA.
DR   EMBL; X80184; CAA56469.1; -; Genomic_DNA.
DR   EMBL; X80185; CAA56470.1; -; Genomic_DNA.
DR   PIR; S23112; S23112.
DR   AlphaFoldDB; P0A3N6; -.
DR   SMR; P0A3N6; -.
DR   PRIDE; P0A3N6; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001809; OM_lipoprot_Borrelia.
DR   InterPro; IPR023322; OM_lipoprot_dom_sf.
DR   Pfam; PF00820; Lipoprotein_1; 1.
DR   PRINTS; PR00968; OUTRSURFACE.
DR   SUPFAM; SSF51087; SSF51087; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid; Signal.
FT   SIGNAL          1..16
FT   CHAIN           17..273
FT                   /note="Outer surface protein A"
FT                   /id="PRO_0000018079"
FT   LIPID           17
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           17
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   273 AA;  29630 MW;  6DC97D97EEA0AEF8 CRC64;
     MKKYLLGIGL ILALIACKQN VSSLDEKNSA SVDLPGEMKV LVSKEKDKDG KYSLKATVDK
     IELKGTSDKD NGSGVLEGTK DDKSKAKLTI ADDLSKTTFE LFKEDGKTLV SRKVSSKDKT
     STDEMFNEKG ELSAKTMTRE NGTKLEYTEM KSDGTGKAKE VLKNFTLEGK VANDKVTLEV
     KEGTVTLSKE IAKSGEVTVA LNDTNTTQAT KKTGAWDSKT STLTISVNSK KTTQLVFTKQ
     DTITVQKYDS AGTNLEGTAV EIKTLDELKN ALK