ID   OSPA_BORBZ              Reviewed;         273 AA.
AC   B7IZU3; P14013; Q44882; Q44964; Q44967; Q44969; Q44971; Q57123; Q57272;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Outer surface protein A;
DE   Flags: Precursor;
GN   Name=ospA; OrderedLocusNames=BbuZS7_A13;
OS   Borreliella burgdorferi (strain ZS7) (Borrelia burgdorferi).
OG   Plasmid ZS7_lp54.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=445985;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2587225; DOI=10.1093/nar/17.21.8864;
RA   Wallich R., Schaible U.E., Simon M.M., Heiberger A., Kramer M.D.;
RT   "Cloning and sequencing of the gene encoding the outer surface protein A
RT   (OspA) of a European Borrelia burgdorferi isolate.";
RL   Nucleic Acids Res. 17:8864-8864(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ZS7;
RX   PubMed=20935092; DOI=10.1128/jb.01158-10;
RA   Schutzer S.E., Fraser-Liggett C.M., Casjens S.R., Qiu W.G., Dunn J.J.,
RA   Mongodin E.F., Luft B.J.;
RT   "Whole-genome sequences of thirteen isolates of Borrelia burgdorferi.";
RL   J. Bacteriol. 193:1018-1020(2011).
RN   [3]
RP   PROTEIN SEQUENCE OF 118-135.
RX   PubMed=1829104; DOI=10.1093/infdis/164.1.123;
RA   Simon M.M., Schaible U.E., Kramer M.D., Eckerskorn C., Museteanu C.,
RA   Muller-Hermelink H.K., Wallich R.;
RT   "Recombinant outer surface protein a from Borrelia burgdorferi induces
RT   antibodies protective against spirochetal infection in mice.";
RL   J. Infect. Dis. 164:123-132(1991).
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Lipid-anchor.
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DR   EMBL; X16467; CAA34487.1; -; Genomic_DNA.
DR   EMBL; CP001199; ACK74228.1; -; Genomic_DNA.
DR   PIR; S14906; MMLYAZ.
DR   RefSeq; WP_012615002.1; NC_011784.1.
DR   AlphaFoldDB; B7IZU3; -.
DR   BMRB; B7IZU3; -.
DR   SMR; B7IZU3; -.
DR   EnsemblBacteria; ACK74228; ACK74228; BbuZS7_A13.
DR   KEGG; bbz:BbuZS7_A13; -.
DR   HOGENOM; CLU_1014382_0_0_12; -.
DR   OMA; ALIACKQ; -.
DR   OrthoDB; 1143880at2; -.
DR   Proteomes; UP000006901; Plasmid ZS7_lp54.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001809; OM_lipoprot_Borrelia.
DR   InterPro; IPR023322; OM_lipoprot_dom_sf.
DR   Pfam; PF00820; Lipoprotein_1; 1.
DR   PRINTS; PR00968; OUTRSURFACE.
DR   SUPFAM; SSF51087; SSF51087; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Direct protein sequencing; Lipoprotein; Membrane;
KW   Palmitate; Plasmid; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           17..273
FT                   /note="Outer surface protein A"
FT                   /id="PRO_0000370271"
FT   LIPID           17
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           17
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   273 AA;  29455 MW;  0889191B09F45EC2 CRC64;
     MKKYLLGIGL ILALIACKQN VSSLDEKNSV SVDLPGEMNV LVSKEKNKDG KYDLIATVDK
     LELKGTSDKN NGSGVLEGVK ADKSKVKLTI SDDLGQTTLE VFKEDGKTLV SKKVTSKDKS
     STEEKFNEKG EVSEKIITRA DGTRLEYTEI KSDGSGKAKE VLKSYVLEGT LTAEKTTLVV
     KEGTVTLSKN ISKSGEVSVE LNDTDSSAAT KKTAAWNSGT STLTITVNSK KTKDLVFTKE
     NTITVQQYDS NGTKLEGSAV EITKLDEIKN ALK