OSPB_BORBU
ID OSPB_BORBU Reviewed; 296 AA.
AC P17739; O50909; Q44963; Q44965; Q44966; Q44968; Q44970; Q44972; Q44975;
AC Q57510;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 2.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=Outer surface protein B;
DE Flags: Precursor;
GN Name=ospB; OrderedLocusNames=BB_A16;
OS Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS (Borrelia burgdorferi).
OG Plasmid lp54.
OC Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX NCBI_TaxID=224326;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX PubMed=2761388; DOI=10.1111/j.1365-2958.1989.tb00194.x;
RA Bergstroem S., Bundoc V., Barbour A.G.;
RT "Molecular analysis of linear plasmid-encoded major surface proteins, OspA
RT and OspB, of the Lyme disease spirochaete Borrelia burgdorferi.";
RL Mol. Microbiol. 3:479-486(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Various strains;
RX PubMed=8121286; DOI=10.1093/oxfordjournals.molbev.a040092;
RA Caporale D.A., Kocher T.D.;
RT "Sequence variation in the outer-surface-protein genes of Borrelia
RT burgdorferi.";
RL Mol. Biol. Evol. 11:51-64(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=HB19;
RX PubMed=7513309; DOI=10.1128/iai.62.5.2037-2045.1994;
RA Sadziene A., Jonsson M., Bergstroem S., Bright R.K., Kennedy R.C.,
RA Barbour A.G.;
RT "A bactericidal antibody to Borrelia burgdorferi is directed against a
RT variable region of the OspB protein.";
RL Infect. Immun. 62:2037-2045(1994).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L.,
RA Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L.,
RA Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M.,
RA van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F.,
RA Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C.,
RA Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B.,
RA Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL Nature 390:580-586(1997).
RN [5]
RP SEQUENCE REVISION TO 198.
RA Mongodin E.F., Fraser-Liggett C.M., Qiu W.-G., Dunn J.J., Luft B.J.,
RA Schutzer S.E., Casjens S.R.;
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane; Lipid-anchor.
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DR EMBL; X14407; CAA32580.1; -; Genomic_DNA.
DR EMBL; L23136; AAA22952.1; -; Genomic_DNA.
DR EMBL; L23137; AAA22954.1; -; Genomic_DNA.
DR EMBL; L23138; AAA20948.1; -; Genomic_DNA.
DR EMBL; L23139; AAA20950.1; -; Genomic_DNA.
DR EMBL; L23140; AAA20952.1; -; Genomic_DNA.
DR EMBL; L23141; AAA20954.1; -; Genomic_DNA.
DR EMBL; L23142; AAA20956.1; -; Genomic_DNA.
DR EMBL; L23143; AAA20958.1; -; Genomic_DNA.
DR EMBL; L23144; AAA20960.1; -; Genomic_DNA.
DR EMBL; L31399; AAA63758.1; -; Genomic_DNA.
DR EMBL; AE000790; AAC66243.2; -; Genomic_DNA.
DR PIR; H70208; H70208.
DR PIR; I40250; I40250.
DR PIR; I40252; I40252.
DR PIR; I40256; I40256.
DR PIR; I40258; I40258.
DR PIR; I40260; I40260.
DR PIR; I40264; I40264.
DR PIR; I40266; I40266.
DR PIR; I40267; I40267.
DR PIR; S06915; S06915.
DR RefSeq; NP_045689.2; NC_001857.2.
DR RefSeq; WP_010890379.1; NC_001857.2.
DR PDB; 1P4P; X-ray; 2.00 A; A=152-296.
DR PDB; 1RJL; X-ray; 2.60 A; C=202-296.
DR PDBsum; 1P4P; -.
DR PDBsum; 1RJL; -.
DR AlphaFoldDB; P17739; -.
DR SMR; P17739; -.
DR DIP; DIP-60765N; -.
DR IntAct; P17739; 1.
DR ABCD; P17739; 1 sequenced antibody.
DR EnsemblBacteria; AAC66243; AAC66243; BB_A16.
DR GeneID; 56568597; -.
DR KEGG; bbu:BB_A16; -.
DR PATRIC; fig|224326.49.peg.1534; -.
DR HOGENOM; CLU_1014382_0_0_12; -.
DR EvolutionaryTrace; P17739; -.
DR Proteomes; UP000001807; Plasmid lp54.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IDA:CAFA.
DR InterPro; IPR001809; OM_lipoprot_Borrelia.
DR InterPro; IPR023322; OM_lipoprot_dom_sf.
DR Pfam; PF00820; Lipoprotein_1; 1.
DR PRINTS; PR00968; OUTRSURFACE.
DR SUPFAM; SSF51087; SSF51087; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Lipoprotein; Membrane; Palmitate;
KW Plasmid; Reference proteome; Signal.
FT SIGNAL 1..15
FT CHAIN 16..296
FT /note="Outer surface protein B"
FT /id="PRO_0000018081"
FT REGION 25..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 16
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000305"
FT LIPID 16
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000305"
FT VARIANT 42
FT /note="H -> Y (in strain: CA7)"
FT VARIANT 89
FT /note="K -> R (in strain: 41552MA)"
FT VARIANT 123
FT /note="T -> S (in strain: CA8)"
FT VARIANT 126
FT /note="A -> T (in strain: 21343WI, 41552MA, 42373NY3, HB19
FT and HB19CT1)"
FT VARIANT 128
FT /note="D -> N (in strain: 21343WI, 41552MA, HB19 and
FT HB19CT1)"
FT VARIANT 132
FT /note="Q -> P (in strain: CA8)"
FT VARIANT 176
FT /note="A -> T (in strain: CA8)"
FT VARIANT 189
FT /note="S -> G (in strain: CA8)"
FT VARIANT 192
FT /note="L -> F (in strain: CA8)"
FT VARIANT 198
FT /note="G -> V (in strain: 21343WI, CA3 and CA7)"
FT VARIANT 218
FT /note="K -> Q (in strain: CA8)"
FT VARIANT 253
FT /note="K -> T (in strain: 21343WI, 41552MA, 42373NY3, HB19
FT and HB19CT1)"
FT CONFLICT 12
FT /note="A -> R (in Ref. 3; AAA63758)"
FT /evidence="ECO:0000305"
FT CONFLICT 198
FT /note="G -> V (in Ref. 1; CAA32580)"
FT /evidence="ECO:0000305"
FT CONFLICT 214
FT /note="R -> I (in Ref. 3; AAA63758)"
FT /evidence="ECO:0000305"
FT STRAND 158..161
FT /evidence="ECO:0007829|PDB:1P4P"
FT STRAND 167..177
FT /evidence="ECO:0007829|PDB:1P4P"
FT STRAND 179..186
FT /evidence="ECO:0007829|PDB:1P4P"
FT HELIX 187..189
FT /evidence="ECO:0007829|PDB:1P4P"
FT STRAND 190..197
FT /evidence="ECO:0007829|PDB:1P4P"
FT STRAND 200..207
FT /evidence="ECO:0007829|PDB:1P4P"
FT STRAND 210..216
FT /evidence="ECO:0007829|PDB:1P4P"
FT STRAND 218..228
FT /evidence="ECO:0007829|PDB:1P4P"
FT STRAND 231..233
FT /evidence="ECO:0007829|PDB:1P4P"
FT STRAND 235..240
FT /evidence="ECO:0007829|PDB:1P4P"
FT HELIX 241..243
FT /evidence="ECO:0007829|PDB:1P4P"
FT STRAND 245..250
FT /evidence="ECO:0007829|PDB:1P4P"
FT STRAND 253..260
FT /evidence="ECO:0007829|PDB:1P4P"
FT STRAND 266..271
FT /evidence="ECO:0007829|PDB:1P4P"
FT STRAND 275..278
FT /evidence="ECO:0007829|PDB:1P4P"
FT HELIX 288..294
FT /evidence="ECO:0007829|PDB:1P4P"
SQ SEQUENCE 296 AA; 31733 MW; 4B54CBABC39880A5 CRC64;
MRLLIGFALA LALIGCAQKG AESIGSQKEN DLNLEDSSKK SHQNAKQDLP AVTEDSVSLF
NGNKIFVSKE KNSSGKYDLR ATIDQVELKG TSDKNNGSGT LEGSKPDKSK VKLTVSADLN
TVTLEAFDAS NQKISSKVTK KQGSITEETL KANKLDSKKL TRSNGTTLEY SQITDADNAT
KAVETLKNSI KLEGSLVGGK TTVEIKEGTV TLKREIEKDG KVKVFLNDTA GSNKKTGKWE
DSTSTLTISA DSKKTKDLVF LTDGTITVQQ YNTAGTSLEG SASEIKNLSE LKNALK
