ID   OSPC_BORBG              Reviewed;         212 AA.
AC   Q08137; Q9S3P4;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Outer surface protein C;
DE            Short=PC;
DE   Flags: Precursor;
GN   Name=ospC;
OS   Borreliella burgdorferi (Lyme disease spirochete) (Borrelia burgdorferi).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=139;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=PKo;
RX   PubMed=1560779; DOI=10.1111/j.1365-2958.1992.tb01495.x;
RA   Fuchs R., Jauris S., Lottspeich F., Preac-Mursic V., Wilske B.,
RA   Soutschek E.;
RT   "Molecular analysis and expression of a Borrelia burgdorferi gene encoding
RT   a 22 kDa protein (pC) in Escherichia coli.";
RL   Mol. Microbiol. 6:503-509(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=WudI;
RX   PubMed=7665660; DOI=10.1128/jcm.33.7.1860-1866.1995;
RA   Jauris-Heipke S., Liegl G., Preac-Mursic V., Roessler D., Schwab E.,
RA   Soutschek E., Will G., Wilske B.;
RT   "Molecular analysis of genes encoding outer surface protein C (OspC) of
RT   Borrelia burgdorferi sensu lato: relationship to ospA genotype and evidence
RT   of lateral gene exchange of ospC.";
RL   J. Clin. Microbiol. 33:1860-1866(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-205.
RC   STRAIN=DK26;
RX   PubMed=8253951; DOI=10.1128/jcm.31.10.2570-2576.1993;
RA   Theisen M., Frederiksen B., Lebech A.M., Vuust J., Hansen K.;
RT   "Polymorphism in ospC gene of Borrelia burgdorferi and immunoreactivity of
RT   OspC protein: implications for taxonomy and for use of OspC protein as a
RT   diagnostic antigen.";
RL   J. Clin. Microbiol. 31:2570-2576(1993).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-212.
RC   STRAIN=JSB;
RX   PubMed=8709845; DOI=10.1111/j.1365-2958.1995.mmi_18020257.x;
RA   Livey I., Gibbs C.P., Schuster R., Dorner F.;
RT   "Evidence for lateral transfer and recombination in OspC variation in Lyme
RT   disease Borrelia.";
RL   Mol. Microbiol. 18:257-269(1995).
CC   -!- FUNCTION: Not known; major immunodominant protein.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Lipid-anchor.
CC   -!- MISCELLANEOUS: In at least some strains (20004, B31, IPA2, not
CC       represented here) this gene is encoded on a 26 kb circular plasmid, so
CC       it is possible this is also encoded on a plasmid in the strains given
CC       here. {ECO:0000303|PubMed:7665660}.
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DR   EMBL; X62162; CAA44093.1; -; Genomic_DNA.
DR   EMBL; X69590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; X73624; CAA52003.1; -; Genomic_DNA.
DR   EMBL; L42883; AAB36991.1; -; Genomic_DNA.
DR   PIR; S20543; S20543.
DR   AlphaFoldDB; Q08137; -.
DR   SMR; Q08137; -.
DR   PRIDE; Q08137; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.120.240; -; 1.
DR   InterPro; IPR001800; Lipoprotein_OspC.
DR   InterPro; IPR036437; OspC-like_sf.
DR   Pfam; PF01441; Lipoprotein_6; 1.
DR   SUPFAM; SSF63515; SSF63515; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Direct protein sequencing; Lipoprotein; Membrane;
KW   Palmitate; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           19..212
FT                   /note="Outer surface protein C"
FT                   /id="PRO_0000018084"
FT   LIPID           19
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           19
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   212 AA;  22500 MW;  C206C231FBF2E7D4 CRC64;
     MKKNTLSAIL MTLFLFISCN NSGKGGDSAS TNPADESAKG PNLTEISKKI TDSNAFVLAV
     KEVETLVLSI DELAKKAIGQ KIDNNNGLAA LNNQNGSLLA GAYAISTLIT EKLSKLKNLE
     ELKTEIAKAK KCSEEFTNKL KSGHADLGKQ DATDDHAKAA ILKTHATTDK GAKEFKDLFE
     SVEGLLKAAQ VALTNSVKEL TSPVVAESPK KP