OSPC_BORBU
ID OSPC_BORBU Reviewed; 210 AA.
AC Q07337; Q9S3P3;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Outer surface protein C;
DE Short=PC;
DE Flags: Precursor;
GN Name=ospC; OrderedLocusNames=BB_B19;
OS Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS (Borrelia burgdorferi).
OG Plasmid lp54.
OC Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX NCBI_TaxID=224326;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX PubMed=8098841; DOI=10.1007/bf00195949;
RA Jauris-Heipke S., Fuchs R., Motz M., Preac-Mursic V., Schwab E., Will G.,
RA Wilske B.;
RT "Genetic heterogenity of the genes coding for the outer surface protein C
RT (OspC) and the flagellin of Borrelia burgdorferi.";
RL Med. Microbiol. Immunol. 182:37-50(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX PubMed=8478108; DOI=10.1128/iai.61.5.2182-2191.1993;
RA Wilske B., Preace-Mursic V., Jauris S., Pradel I., Soutschek E., Schwab E.,
RA Wanner G.;
RT "Immunological and molecular polymorphisms of OspC, an immunodominant major
RT outer surface protein of Borrelia burgdorferi.";
RL Infect. Immun. 61:2182-2191(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX PubMed=8225587; DOI=10.1128/iai.61.12.5097-5105.1993;
RA Padula S.J., Sampieri A., Dias F., Szczepanski A., Ryan R.W.;
RT "Molecular characterization and expression of p23 (OspC) from a North
RT American strain of Borrelia burgdorferi.";
RL Infect. Immun. 61:5097-5105(1993).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=PKa;
RX PubMed=7665660; DOI=10.1128/jcm.33.7.1860-1866.1995;
RA Jauris-Heipke S., Liegl G., Preac-Mursic V., Roessler D., Schwab E.,
RA Soutschek E., Will G., Wilske B.;
RT "Molecular analysis of genes encoding outer surface protein C (OspC) of
RT Borrelia burgdorferi sensu lato: relationship to ospA genotype and evidence
RT of lateral gene exchange of ospC.";
RL J. Clin. Microbiol. 33:1860-1866(1995).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX PubMed=7494039; DOI=10.1128/jcm.33.9.2415-2420.1995;
RA Fukunaga M., Hamase A.;
RT "Outer surface protein C gene sequence analysis of Borrelia burgdorferi
RT sensu lato isolates from Japan.";
RL J. Clin. Microbiol. 33:2415-2420(1995).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L.,
RA Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L.,
RA Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M.,
RA van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F.,
RA Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C.,
RA Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B.,
RA Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL Nature 390:580-586(1997).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-210.
RC STRAIN=Ip2;
RX PubMed=8709845; DOI=10.1111/j.1365-2958.1995.mmi_18020257.x;
RA Livey I., Gibbs C.P., Schuster R., Dorner F.;
RT "Evidence for lateral transfer and recombination in OspC variation in Lyme
RT disease Borrelia.";
RL Mol. Microbiol. 18:257-269(1995).
CC -!- FUNCTION: Not known; major immunodominant protein.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane; Lipid-anchor.
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DR EMBL; X69596; CAA49306.1; -; Genomic_DNA.
DR EMBL; U01894; AAA16058.1; -; Unassigned_DNA.
DR EMBL; X69589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; D49497; BAA08457.1; -; Genomic_DNA.
DR EMBL; AE000792; AAC66329.1; -; Genomic_DNA.
DR EMBL; L42887; AAB36995.1; -; Genomic_DNA.
DR PIR; G70218; G70218.
DR PIR; S69927; S69927.
DR RefSeq; NP_047005.1; NC_001903.1.
DR RefSeq; WP_010890595.1; NC_001903.1.
DR PDB; 1GGQ; X-ray; 2.51 A; A/B/C/D=38-210.
DR PDBsum; 1GGQ; -.
DR AlphaFoldDB; Q07337; -.
DR BMRB; Q07337; -.
DR SMR; Q07337; -.
DR PRIDE; Q07337; -.
DR EnsemblBacteria; AAC66329; AAC66329; BB_B19.
DR KEGG; bbu:BB_B19; -.
DR PATRIC; fig|224326.49.peg.1608; -.
DR HOGENOM; CLU_089887_0_0_12; -.
DR OMA; IGKKIHQ; -.
DR EvolutionaryTrace; Q07337; -.
DR Proteomes; UP000001807; Plasmid cp26.
DR GO; GO:0031240; C:external side of cell outer membrane; IDA:CAFA.
DR GO; GO:0016020; C:membrane; IDA:CAFA.
DR Gene3D; 1.20.120.240; -; 1.
DR InterPro; IPR001800; Lipoprotein_OspC.
DR InterPro; IPR036437; OspC-like_sf.
DR Pfam; PF01441; Lipoprotein_6; 1.
DR SUPFAM; SSF63515; SSF63515; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Lipoprotein; Membrane; Palmitate;
KW Plasmid; Reference proteome; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 19..210
FT /note="Outer surface protein C"
FT /id="PRO_0000018083"
FT LIPID 19
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 19
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT HELIX 42..75
FT /evidence="ECO:0007829|PDB:1GGQ"
FT TURN 76..78
FT /evidence="ECO:0007829|PDB:1GGQ"
FT STRAND 79..82
FT /evidence="ECO:0007829|PDB:1GGQ"
FT TURN 83..85
FT /evidence="ECO:0007829|PDB:1GGQ"
FT STRAND 86..89
FT /evidence="ECO:0007829|PDB:1GGQ"
FT HELIX 95..113
FT /evidence="ECO:0007829|PDB:1GGQ"
FT TURN 118..120
FT /evidence="ECO:0007829|PDB:1GGQ"
FT HELIX 121..140
FT /evidence="ECO:0007829|PDB:1GGQ"
FT HELIX 142..145
FT /evidence="ECO:0007829|PDB:1GGQ"
FT STRAND 146..148
FT /evidence="ECO:0007829|PDB:1GGQ"
FT HELIX 152..159
FT /evidence="ECO:0007829|PDB:1GGQ"
FT TURN 167..169
FT /evidence="ECO:0007829|PDB:1GGQ"
FT HELIX 170..195
FT /evidence="ECO:0007829|PDB:1GGQ"
FT HELIX 196..199
FT /evidence="ECO:0007829|PDB:1GGQ"
SQ SEQUENCE 210 AA; 22341 MW; 7A4FC978F91777BF CRC64;
MKKNTLSAIL MTLFLFISCN NSGKDGNTSA NSADESVKGP NLTEISKKIT DSNAVLLAVK
EVEALLSSID EIAAKAIGKK IHQNNGLDTE NNHNGSLLAG AYAISTLIKQ KLDGLKNEGL
KEKIDAAKKC SETFTNKLKE KHTDLGKEGV TDADAKEAIL KTNGTKTKGA EELGKLFESV
EVLSKAAKEM LANSVKELTS PVVAESPKKP
