ID   OSPG_SHIDS              Reviewed;         196 AA.
AC   Q326Z4;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Protein kinase OspG;
DE            EC=2.7.-.-;
DE   AltName: Full=Effector protein OspG;
GN   Name=ospG; OrderedLocusNames=SDY_P101;
OS   Shigella dysenteriae serotype 1 (strain Sd197).
OG   Plasmid pSD1_197.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=300267;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sd197;
RX   PubMed=16275786; DOI=10.1093/nar/gki954;
RA   Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J.,
RA   Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J.,
RA   Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J.,
RA   Jin Q.;
RT   "Genome dynamics and diversity of Shigella species, the etiologic agents of
RT   bacillary dysentery.";
RL   Nucleic Acids Res. 33:6445-6458(2005).
CC   -!- FUNCTION: Effector proteins function to alter host cell physiology and
CC       promote bacterial survival in host tissues. This protein is a kinase
CC       that is involved in down-regulation of the host innate response induced
CC       by invasive bacteria (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Host cell {ECO:0000250}.
CC       Note=Secreted via Mxi-Spa type III secretion system (TTSS), and
CC       delivered into the host cell. {ECO:0000250}.
CC   -!- PTM: Autophosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000035; ABB64614.1; -; Genomic_DNA.
DR   RefSeq; WP_000705601.1; NC_007607.1.
DR   RefSeq; YP_406102.1; NC_007607.1.
DR   AlphaFoldDB; Q326Z4; -.
DR   SMR; Q326Z4; -.
DR   EnsemblBacteria; ABB64614; ABB64614; SDY_P101.
DR   KEGG; sdy:SDY_P101; -.
DR   PATRIC; fig|300267.13.peg.5654; -.
DR   HOGENOM; CLU_120872_0_0_6; -.
DR   OMA; YTEYYSA; -.
DR   Proteomes; UP000002716; Plasmid pSD1_197.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
DR   GO; GO:0016301; F:kinase activity; ISS:UniProtKB.
DR   GO; GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   Kinase; Phosphoprotein; Plasmid; Reference proteome; Secreted; Transferase;
KW   Virulence.
FT   CHAIN           1..196
FT                   /note="Protein kinase OspG"
FT                   /id="PRO_0000395878"
SQ   SEQUENCE   196 AA;  22570 MW;  E90908CB43BCB28A CRC64;
     MKITSTIIQT PFPFENNNSH AGIVTEPILG KLIGQGSTAE IFEDVNDSSA LYKKYDLIGN
     QYNEILEMAW QESELFNAFY GDEASVVIQY GGDVYLRMLR VPGTPLSDID TADIPDNIES
     LYLQLICKLN ELSIIHYDLN TGNMLYDKES ESLFPIDFRN IYAEYYAATK KDKEIIDRRL
     QMRTNDFYSL LNRKYL