OSR1_BOVIN
ID OSR1_BOVIN Reviewed; 267 AA.
AC Q08DS3;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Protein odd-skipped-related 1;
GN Name=OSR1; Synonyms=ODD1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal spinal cord;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that plays a role in the regulation of
CC embryonic heart and urogenital development. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Odd C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI23592.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; BC123591; AAI23592.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001070384.2; NM_001076916.2.
DR AlphaFoldDB; Q08DS3; -.
DR SMR; Q08DS3; -.
DR STRING; 9913.ENSBTAP00000010670; -.
DR PaxDb; Q08DS3; -.
DR Ensembl; ENSBTAT00000066336; ENSBTAP00000055571; ENSBTAG00000008113.
DR GeneID; 539430; -.
DR KEGG; bta:539430; -.
DR CTD; 130497; -.
DR VEuPathDB; HostDB:ENSBTAG00000008113; -.
DR VGNC; VGNC:32476; OSR1.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000158993; -.
DR HOGENOM; CLU_051854_0_0_1; -.
DR InParanoid; Q08DS3; -.
DR OMA; KPAKIKC; -.
DR OrthoDB; 1318335at2759; -.
DR TreeFam; TF350876; -.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000008113; Expressed in aorta and 91 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0072111; P:cell proliferation involved in kidney development; ISS:UniProtKB.
DR GO; GO:0071300; P:cellular response to retinoic acid; IEA:Ensembl.
DR GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
DR GO; GO:0036023; P:embryonic skeletal limb joint morphogenesis; IEA:Ensembl.
DR GO; GO:0008406; P:gonad development; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; ISS:UniProtKB.
DR GO; GO:0048389; P:intermediate mesoderm development; IEA:Ensembl.
DR GO; GO:0072143; P:mesangial cell development; ISS:UniProtKB.
DR GO; GO:0072180; P:mesonephric duct morphogenesis; IEA:Ensembl.
DR GO; GO:0090094; P:metanephric cap mesenchymal cell proliferation involved in metanephros development; IEA:Ensembl.
DR GO; GO:0072207; P:metanephric epithelium development; ISS:UniProtKB.
DR GO; GO:0072239; P:metanephric glomerulus vasculature development; ISS:UniProtKB.
DR GO; GO:0072259; P:metanephric interstitial fibroblast development; ISS:UniProtKB.
DR GO; GO:0072162; P:metanephric mesenchymal cell differentiation; ISS:UniProtKB.
DR GO; GO:0072075; P:metanephric mesenchyme development; ISS:UniProtKB.
DR GO; GO:0072234; P:metanephric nephron tubule development; ISS:UniProtKB.
DR GO; GO:0072208; P:metanephric smooth muscle tissue development; ISS:UniProtKB.
DR GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:1905408; P:negative regulation of creatine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0072183; P:negative regulation of nephron tubule epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:2000650; P:negative regulation of sodium ion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0042476; P:odontogenesis; IEA:Ensembl.
DR GO; GO:0072268; P:pattern specification involved in metanephros development; IEA:Ensembl.
DR GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:UniProtKB.
DR GO; GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0048793; P:pronephros development; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0072184; P:renal vesicle progenitor cell differentiation; ISS:UniProtKB.
DR GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0072168; P:specification of anterior mesonephric tubule identity; ISS:UniProtKB.
DR GO; GO:0072169; P:specification of posterior mesonephric tubule identity; ISS:UniProtKB.
DR GO; GO:0048863; P:stem cell differentiation; ISS:UniProtKB.
DR GO; GO:0072190; P:ureter urothelium development; ISS:UniProtKB.
DR GO; GO:0001657; P:ureteric bud development; IEA:Ensembl.
DR GO; GO:0001655; P:urogenital system development; ISS:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW Metal-binding; Methylation; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..267
FT /note="Protein odd-skipped-related 1"
FT /id="PRO_0000402804"
FT ZN_FING 176..198
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 204..226
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 232..254
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 130..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 117
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q9WVG7"
SQ SEQUENCE 267 AA; 29626 MW; E1C59BC05B8D0E6E CRC64;
MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV HLHQWTLGYP
AMHLPRSSFS KVPGAVSSLV DARFQLPAFP WFPHVIQPKP EITAGGSGPA ALKTKPRFDF
ANLALAATQE DPSKLGRGEG PGSPAGGLGA LLDVTKLSPE KKPTRGRLPS KTKKEFVCKF
CGRHFTKSYN LLIHERTHTD ERPYTCDICH KAFRRQDHLR DHRYIHSKEK PFKCQECGKG
FCQSRTLAVH KTLHSQVKEL KTSKIKC