OSR1_MOUSE
ID OSR1_MOUSE Reviewed; 266 AA.
AC Q9WVG7;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Protein odd-skipped-related 1;
GN Name=Osr1; Synonyms=Odd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10473132; DOI=10.1016/s0925-4773(99)00058-1;
RA So P.L., Danielian P.S.;
RT "Cloning and expression analysis of a mouse gene related to Drosophila odd-
RT skipped.";
RL Mech. Dev. 84:157-160(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=16223478; DOI=10.1016/j.ydbio.2005.09.024;
RA Wang Q., Lan Y., Cho E.S., Maltby K.M., Jiang R.;
RT "Odd-skipped related 1 (Odd 1) is an essential regulator of heart and
RT urogenital development.";
RL Dev. Biol. 288:582-594(2005).
RN [4]
RP INDUCTION.
RX PubMed=18804520; DOI=10.1016/j.gene.2008.08.015;
RA Yamauchi M., Kawai S., Kato T., Ooshima T., Amano A.;
RT "Odd-skipped related 1 gene expression is regulated by Runx2 and Ikzf1
RT transcription factors.";
RL Gene 426:81-90(2008).
RN [5]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-116, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Transcription factor that plays a role in the regulation of
CC embryonic heart and urogenital development.
CC {ECO:0000269|PubMed:16223478}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: During early embryogenesis it is expressed in the
CC intermediate mesoderm and in a dynamic pattern during limb and
CC branchial arch development. Is expressed from the earliest stage of
CC intermediate development. Is expressed in the dorsal atrial wall,
CC including the developing primary atrial septum and the venous valve.
CC {ECO:0000269|PubMed:16223478}.
CC -!- INDUCTION: Transcriptionally regulated by Ikzf1 and Runx2.
CC {ECO:0000269|PubMed:18804520}.
CC -!- DISRUPTION PHENOTYPE: Mice die prenatally with severe heart defects
CC including defective atrioventricular junction and venous valves. They
CC never initiate metanephric kidney formation. Nephrogenic mesenchyme
CC undergo massive apoptosis, which causes a disruption of nephric duct
CC elongation and failure of metanephric induction.
CC {ECO:0000269|PubMed:16223478}.
CC -!- SIMILARITY: Belongs to the Odd C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; AF117814; AAD37115.1; -; mRNA.
DR EMBL; BC023922; AAH23922.1; -; mRNA.
DR CCDS; CCDS25809.1; -.
DR RefSeq; NP_035989.1; NM_011859.3.
DR AlphaFoldDB; Q9WVG7; -.
DR SMR; Q9WVG7; -.
DR BioGRID; 204828; 1.
DR STRING; 10090.ENSMUSP00000055486; -.
DR iPTMnet; Q9WVG7; -.
DR PhosphoSitePlus; Q9WVG7; -.
DR PaxDb; Q9WVG7; -.
DR PRIDE; Q9WVG7; -.
DR ProteomicsDB; 293530; -.
DR Antibodypedia; 12948; 376 antibodies from 30 providers.
DR DNASU; 23967; -.
DR Ensembl; ENSMUST00000057021; ENSMUSP00000055486; ENSMUSG00000048387.
DR GeneID; 23967; -.
DR KEGG; mmu:23967; -.
DR UCSC; uc007nao.2; mouse.
DR CTD; 130497; -.
DR MGI; MGI:1344424; Osr1.
DR VEuPathDB; HostDB:ENSMUSG00000048387; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000158993; -.
DR HOGENOM; CLU_051854_0_0_1; -.
DR InParanoid; Q9WVG7; -.
DR OMA; KPAKIKC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9WVG7; -.
DR TreeFam; TF350876; -.
DR BioGRID-ORCS; 23967; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Osr1; mouse.
DR PRO; PR:Q9WVG7; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q9WVG7; protein.
DR Bgee; ENSMUSG00000048387; Expressed in dorsal pancreas and 218 other tissues.
DR ExpressionAtlas; Q9WVG7; baseline and differential.
DR Genevisible; Q9WVG7; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0019898; C:extrinsic component of membrane; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0030154; P:cell differentiation; IGI:BHF-UCL.
DR GO; GO:0072111; P:cell proliferation involved in kidney development; IMP:UniProtKB.
DR GO; GO:0071300; P:cellular response to retinoic acid; IEP:UniProtKB.
DR GO; GO:0002062; P:chondrocyte differentiation; IGI:BHF-UCL.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IGI:BHF-UCL.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; IGI:BHF-UCL.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; IGI:BHF-UCL.
DR GO; GO:0072498; P:embryonic skeletal joint development; IGI:BHF-UCL.
DR GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IGI:BHF-UCL.
DR GO; GO:0036023; P:embryonic skeletal limb joint morphogenesis; IGI:BHF-UCL.
DR GO; GO:0008406; P:gonad development; IMP:MGI.
DR GO; GO:0007507; P:heart development; IMP:UniProtKB.
DR GO; GO:0048389; P:intermediate mesoderm development; IMP:MGI.
DR GO; GO:0072143; P:mesangial cell development; IMP:UniProtKB.
DR GO; GO:0072180; P:mesonephric duct morphogenesis; IMP:UniProtKB.
DR GO; GO:0001823; P:mesonephros development; IMP:UniProtKB.
DR GO; GO:0090094; P:metanephric cap mesenchymal cell proliferation involved in metanephros development; IMP:UniProtKB.
DR GO; GO:0072207; P:metanephric epithelium development; IMP:UniProtKB.
DR GO; GO:0072239; P:metanephric glomerulus vasculature development; IMP:UniProtKB.
DR GO; GO:0072259; P:metanephric interstitial fibroblast development; IMP:UniProtKB.
DR GO; GO:0072162; P:metanephric mesenchymal cell differentiation; IMP:UniProtKB.
DR GO; GO:0072075; P:metanephric mesenchyme development; IDA:UniProtKB.
DR GO; GO:0072133; P:metanephric mesenchyme morphogenesis; IMP:UniProtKB.
DR GO; GO:0072234; P:metanephric nephron tubule development; IMP:UniProtKB.
DR GO; GO:0072208; P:metanephric smooth muscle tissue development; IMP:UniProtKB.
DR GO; GO:0001656; P:metanephros development; IMP:MGI.
DR GO; GO:0042474; P:middle ear morphogenesis; IGI:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
DR GO; GO:1905408; P:negative regulation of creatine transmembrane transporter activity; ISO:MGI.
DR GO; GO:0030857; P:negative regulation of epithelial cell differentiation; IMP:UniProtKB.
DR GO; GO:0072183; P:negative regulation of nephron tubule epithelial cell differentiation; IMP:UniProtKB.
DR GO; GO:2000650; P:negative regulation of sodium ion transmembrane transporter activity; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:BHF-UCL.
DR GO; GO:0042476; P:odontogenesis; IGI:UniProtKB.
DR GO; GO:0072268; P:pattern specification involved in metanephros development; IMP:UniProtKB.
DR GO; GO:0030501; P:positive regulation of bone mineralization; IGI:BHF-UCL.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IGI:UniProtKB.
DR GO; GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0072166; P:posterior mesonephric tubule development; IMP:UniProtKB.
DR GO; GO:0048793; P:pronephros development; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0072184; P:renal vesicle progenitor cell differentiation; IMP:UniProtKB.
DR GO; GO:0060021; P:roof of mouth development; IGI:UniProtKB.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IMP:MGI.
DR GO; GO:0072168; P:specification of anterior mesonephric tubule identity; IMP:UniProtKB.
DR GO; GO:0072169; P:specification of posterior mesonephric tubule identity; IMP:UniProtKB.
DR GO; GO:0048863; P:stem cell differentiation; IDA:UniProtKB.
DR GO; GO:0072190; P:ureter urothelium development; IMP:UniProtKB.
DR GO; GO:0001657; P:ureteric bud development; IMP:UniProtKB.
DR GO; GO:0001655; P:urogenital system development; IMP:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Metal-binding; Methylation; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..266
FT /note="Protein odd-skipped-related 1"
FT /id="PRO_0000047005"
FT ZN_FING 175..197
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 203..225
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 231..253
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MOD_RES 116
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
SQ SEQUENCE 266 AA; 29584 MW; CC9948ACFC90F7A5 CRC64;
MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV HLHQWTLGYP
AMHLPRSSFS KVPGAVSSLM DARFQLPAFP WFPHVIHPKP EITAGGSGAA LKTKPRFDFA
NLALAATQED PTKLGRGEGP GSPAGGLGAL LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC
GRHFTKSYNL LIHERTHTDE RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF
CQSRTLAVHK TLHSQVKELK TSKIKC
