OSR1_RAT
ID OSR1_RAT Reviewed; 266 AA.
AC B0K011;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Protein odd-skipped-related 1;
GN Name=Osr1; Synonyms=Odd1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcription factor that plays a role in the regulation of
CC embryonic heart and urogenital development. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Odd C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; CH473947; EDM03089.1; -; Genomic_DNA.
DR EMBL; BC159410; AAI59411.1; -; mRNA.
DR RefSeq; NP_001100186.1; NM_001106716.2.
DR RefSeq; XP_006239948.1; XM_006239886.2.
DR AlphaFoldDB; B0K011; -.
DR SMR; B0K011; -.
DR STRING; 10116.ENSRNOP00000005666; -.
DR PhosphoSitePlus; B0K011; -.
DR PaxDb; B0K011; -.
DR GeneID; 298878; -.
DR KEGG; rno:298878; -.
DR CTD; 130497; -.
DR RGD; 1311807; Osr1.
DR VEuPathDB; HostDB:ENSRNOG00000004210; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_051854_0_0_1; -.
DR InParanoid; B0K011; -.
DR OMA; KPAKIKC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; B0K011; -.
DR TreeFam; TF350876; -.
DR PRO; PR:B0K011; -.
DR Proteomes; UP000002494; Chromosome 6.
DR Proteomes; UP000234681; Chromosome 6.
DR Bgee; ENSRNOG00000004210; Expressed in skeletal muscle tissue and 17 other tissues.
DR GO; GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL.
DR GO; GO:0019898; C:extrinsic component of membrane; IDA:ParkinsonsUK-UCL.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0030154; P:cell differentiation; ISO:RGD.
DR GO; GO:0072111; P:cell proliferation involved in kidney development; ISS:UniProtKB.
DR GO; GO:0071300; P:cellular response to retinoic acid; ISO:RGD.
DR GO; GO:0002062; P:chondrocyte differentiation; ISO:RGD.
DR GO; GO:0042733; P:embryonic digit morphogenesis; ISO:RGD.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; ISO:RGD.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; ISO:RGD.
DR GO; GO:0072498; P:embryonic skeletal joint development; ISO:RGD.
DR GO; GO:0060272; P:embryonic skeletal joint morphogenesis; ISO:RGD.
DR GO; GO:0036023; P:embryonic skeletal limb joint morphogenesis; ISO:RGD.
DR GO; GO:0008406; P:gonad development; ISO:RGD.
DR GO; GO:0007507; P:heart development; ISS:UniProtKB.
DR GO; GO:0048389; P:intermediate mesoderm development; ISO:RGD.
DR GO; GO:0072143; P:mesangial cell development; ISS:UniProtKB.
DR GO; GO:0072180; P:mesonephric duct morphogenesis; ISS:UniProtKB.
DR GO; GO:0001823; P:mesonephros development; ISS:UniProtKB.
DR GO; GO:0090094; P:metanephric cap mesenchymal cell proliferation involved in metanephros development; ISS:UniProtKB.
DR GO; GO:0072207; P:metanephric epithelium development; ISS:UniProtKB.
DR GO; GO:0072239; P:metanephric glomerulus vasculature development; ISS:UniProtKB.
DR GO; GO:0072259; P:metanephric interstitial fibroblast development; ISS:UniProtKB.
DR GO; GO:0072162; P:metanephric mesenchymal cell differentiation; ISS:UniProtKB.
DR GO; GO:0072075; P:metanephric mesenchyme development; ISS:UniProtKB.
DR GO; GO:0072133; P:metanephric mesenchyme morphogenesis; ISS:UniProtKB.
DR GO; GO:0072234; P:metanephric nephron tubule development; ISS:UniProtKB.
DR GO; GO:0072208; P:metanephric smooth muscle tissue development; ISS:UniProtKB.
DR GO; GO:0001656; P:metanephros development; ISO:RGD.
DR GO; GO:0042474; P:middle ear morphogenesis; ISS:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:1905408; P:negative regulation of creatine transmembrane transporter activity; ISO:RGD.
DR GO; GO:0030857; P:negative regulation of epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0072183; P:negative regulation of nephron tubule epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:2000650; P:negative regulation of sodium ion transmembrane transporter activity; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0042476; P:odontogenesis; ISS:UniProtKB.
DR GO; GO:0072268; P:pattern specification involved in metanephros development; ISS:UniProtKB.
DR GO; GO:0030501; P:positive regulation of bone mineralization; ISO:RGD.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:UniProtKB.
DR GO; GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0072166; P:posterior mesonephric tubule development; ISS:UniProtKB.
DR GO; GO:0048793; P:pronephros development; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0072184; P:renal vesicle progenitor cell differentiation; ISS:UniProtKB.
DR GO; GO:0060021; P:roof of mouth development; ISS:UniProtKB.
DR GO; GO:0035725; P:sodium ion transmembrane transport; ISO:RGD.
DR GO; GO:0072168; P:specification of anterior mesonephric tubule identity; ISS:UniProtKB.
DR GO; GO:0072169; P:specification of posterior mesonephric tubule identity; ISS:UniProtKB.
DR GO; GO:0048863; P:stem cell differentiation; ISS:UniProtKB.
DR GO; GO:0072190; P:ureter urothelium development; ISS:UniProtKB.
DR GO; GO:0001657; P:ureteric bud development; ISS:UniProtKB.
DR GO; GO:0001655; P:urogenital system development; ISS:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW Metal-binding; Methylation; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..266
FT /note="Protein odd-skipped-related 1"
FT /id="PRO_0000402805"
FT ZN_FING 175..197
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 203..225
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 231..253
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MOD_RES 116
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q9WVG7"
SQ SEQUENCE 266 AA; 29584 MW; CC9948ACFC90F7A5 CRC64;
MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV HLHQWTLGYP
AMHLPRSSFS KVPGAVSSLM DARFQLPAFP WFPHVIHPKP EITAGGSGAA LKTKPRFDFA
NLALAATQED PTKLGRGEGP GSPAGGLGAL LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC
GRHFTKSYNL LIHERTHTDE RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF
CQSRTLAVHK TLHSQVKELK TSKIKC
