ID   OSR1_XENLA              Reviewed;         259 AA.
AC   P86413; D0Z721;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Protein odd-skipped-related 1 {ECO:0000303|PubMed:17011543};
DE            Short=XOsr1 {ECO:0000303|PubMed:17011543};
GN   Name=osr1 {ECO:0000303|PubMed:17011543};
GN   Synonyms=odd1 {ECO:0000303|PubMed:17011543};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Gastrula {ECO:0000269|Ref.1};
RA   Kitayama A., Terasaka C., Mochii M., Ueno N., Shin-i T., Kohara Y.;
RT   "Expressed genes in X. laevis embryo.";
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   IDENTIFICATION, FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=17011543; DOI=10.1016/j.ydbio.2006.08.063;
RA   Tena J.J., Neto A., de la Calle-Mustienes E., Bras-Pereira C., Casares F.,
RA   Gomez-Skarmeta J.L.;
RT   "Odd-skipped genes encode repressors that control kidney development.";
RL   Dev. Biol. 301:518-531(2007).
CC   -!- FUNCTION: Transcriptional repressor. Required for pronephric kidney
CC       development. {ECO:0000269|PubMed:17011543}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17011543,
CC       ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: At early gastrula stage, expressed in the
CC       involuting mesoderm and endoderm. During neurulation, expressed in the
CC       pronephric primordium, following expression of osr2. During tailbud
CC       (stage 35), expressed in the rectal diverticulum and in the kidney
CC       ducts. {ECO:0000269|PubMed:17011543}.
CC   -!- SIMILARITY: Belongs to the Odd C2H2-type zinc-finger protein family.
CC       {ECO:0000255}.
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DR   EMBL; BJ624584; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BJ637112; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BN000922; CAJ80803.1; -; mRNA.
DR   RefSeq; NP_001161853.1; NM_001168381.1.
DR   AlphaFoldDB; P86413; -.
DR   SMR; P86413; -.
DR   GeneID; 100313967; -.
DR   KEGG; xla:100313967; -.
DR   CTD; 100313967; -.
DR   Xenbase; XB-GENE-17344349; osr1.L.
DR   OMA; KPAKIKC; -.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 100313967; Expressed in zone of skin and 15 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0071300; P:cellular response to retinoic acid; IEP:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR   GO; GO:0048793; P:pronephros development; IMP:UniProtKB.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Developmental protein; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..259
FT                   /note="Protein odd-skipped-related 1"
FT                   /id="PRO_0000390730"
FT   ZN_FING         168..190
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         196..218
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         224..246
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   259 AA;  29418 MW;  B6E57E798FD8C116 CRC64;
     MGSKTLPAPV PIHPSLQLTN YSFLQAFNGL PVPAEHVPNL YGFSALHAVH LHQWTLGYPT
     LHLPRSSFSK VPGVSSLVDS RFQIPTFPLF PHMIHPKQES PNLSNKTKPR FDFANLAVAA
     TQEDHCKLGL MNDQGSPPAM GGLLDVTKLT PEKKPTRGRL PSKTKKEFVC KFCGRHFTKS
     YNLLIHERTH TDERPYTCDI CHKAFRRQDH LRDHRYIHSK EKPFKCQECG KGFCQSRTLA
     VHKTLHTQVK ELKPSKIKC