ID   OSR1_XENTR              Reviewed;         259 AA.
AC   Q66JF8;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Protein odd-skipped-related 1 {ECO:0000312|EMBL:AAH80931.1};
DE            Short=XOsr1 {ECO:0000303|PubMed:17011543};
GN   Name=osr1 {ECO:0000312|EMBL:AAH80931.1}; ORFNames=TGas143j06.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ81997.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000312|EMBL:CAJ81997.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:CAJ81997.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tail bud {ECO:0000312|EMBL:AAH80931.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000305}
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=17011543; DOI=10.1016/j.ydbio.2006.08.063;
RA   Tena J.J., Neto A., de la Calle-Mustienes E., Bras-Pereira C., Casares F.,
RA   Gomez-Skarmeta J.L.;
RT   "Odd-skipped genes encode repressors that control kidney development.";
RL   Dev. Biol. 301:518-531(2007).
CC   -!- FUNCTION: Transcriptional repressor (By similarity). Required for
CC       pronephric kidney development. {ECO:0000250|UniProtKB:P86413,
CC       ECO:0000269|PubMed:17011543}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P86413}.
CC   -!- DISRUPTION PHENOTYPE: Embryos show a down-regulation of early
CC       pronephric markers lhx1/lim1 and pax8, and disruption of pronephric
CC       development. {ECO:0000269|PubMed:17011543}.
CC   -!- SIMILARITY: Belongs to the Odd C2H2-type zinc-finger protein family.
CC       {ECO:0000255}.
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DR   EMBL; CR761835; CAJ81997.1; -; mRNA.
DR   EMBL; BC080931; AAH80931.1; -; mRNA.
DR   RefSeq; NP_001008046.1; NM_001008045.1.
DR   AlphaFoldDB; Q66JF8; -.
DR   SMR; Q66JF8; -.
DR   STRING; 8364.ENSXETP00000017518; -.
DR   PaxDb; Q66JF8; -.
DR   DNASU; 493408; -.
DR   GeneID; 493408; -.
DR   KEGG; xtr:493408; -.
DR   CTD; 130497; -.
DR   Xenbase; XB-GENE-481410; osr1.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_051854_0_0_1; -.
DR   InParanoid; Q66JF8; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q66JF8; -.
DR   TreeFam; TF350876; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000036783; Expressed in neurula embryo and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0035779; P:angioblast cell differentiation; IEA:Ensembl.
DR   GO; GO:0048389; P:intermediate mesoderm development; IEA:Ensembl.
DR   GO; GO:0048382; P:mesendoderm development; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0033339; P:pectoral fin development; IEA:Ensembl.
DR   GO; GO:0072112; P:podocyte differentiation; IEA:Ensembl.
DR   GO; GO:0035777; P:pronephric distal tubule development; IEA:Ensembl.
DR   GO; GO:0035775; P:pronephric glomerulus morphogenesis; IEA:Ensembl.
DR   GO; GO:0035778; P:pronephric nephron tubule epithelial cell differentiation; IEA:Ensembl.
DR   GO; GO:0035776; P:pronephric proximal tubule development; IEA:Ensembl.
DR   GO; GO:0048793; P:pronephros development; IMP:UniProtKB.
DR   GO; GO:1903224; P:regulation of endodermal cell differentiation; IEA:Ensembl.
DR   GO; GO:1900107; P:regulation of nodal signaling pathway; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0001655; P:urogenital system development; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Developmental protein; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..259
FT                   /note="Protein odd-skipped-related 1"
FT                   /id="PRO_0000390731"
FT   ZN_FING         168..190
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         196..218
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         224..246
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   259 AA;  29492 MW;  33578135916D5792 CRC64;
     MGSKTLPAPV PIHPSLQLTN YSFLQAFNGL PVPAEHMPNL YGFSALHAVH LHQWTLGYPT
     LHLPRSSFSK VPGVSSLVDS RFQIPTFPLF PHMIHPKQES PNLSNKTKPR FDFANLALAA
     TQEDHCKLGQ MDDQGSPPTI GGLLDVTKLT PEKKPTRGRL PSKTKKEFVC KFCGRHFTKS
     YNLLIHERTH TDERPYTCDI CHKAFRRQDH LRDHRYIHSK EKPFKCQECG KGFCQSRTLA
     VHKTLHTQVK ELKPSKIKC