ID   OSR2A_XENLA             Reviewed;         271 AA.
AC   Q32NK7;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Protein odd-skipped-related 2-A;
DE            Short=XOsr2 {ECO:0000303|PubMed:17011543};
GN   Name=osr2-a; Synonyms=osr2 {ECO:0000303|PubMed:17011543};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAI08580.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAI08580.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=17011543; DOI=10.1016/j.ydbio.2006.08.063;
RA   Tena J.J., Neto A., de la Calle-Mustienes E., Bras-Pereira C., Casares F.,
RA   Gomez-Skarmeta J.L.;
RT   "Odd-skipped genes encode repressors that control kidney development.";
RL   Dev. Biol. 301:518-531(2007).
CC   -!- FUNCTION: Transcriptional repressor. Required for pronephric kidney
CC       development. {ECO:0000269|PubMed:17011543}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17011543,
CC       ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: At early gastrula stage, expressed in the
CC       involuting mesoderm and endoderm. At the end of gastrulation, expressed
CC       in the intermediate mesoderm. During neurulation, expressed in the
CC       pronephric primordium, preceding expression of osr1. During tailbud
CC       (stage 35), expressed broadly in both the kidney ducts and tubules.
CC       {ECO:0000269|PubMed:17011543}.
CC   -!- SIMILARITY: Belongs to the Odd C2H2-type zinc-finger protein family.
CC       {ECO:0000255}.
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DR   EMBL; BC108579; AAI08580.1; -; mRNA.
DR   RefSeq; NP_001089872.1; NM_001096403.1.
DR   AlphaFoldDB; Q32NK7; -.
DR   BMRB; Q32NK7; -.
DR   SMR; Q32NK7; -.
DR   DNASU; 734939; -.
DR   GeneID; 734939; -.
DR   KEGG; xla:734939; -.
DR   CTD; 734939; -.
DR   Xenbase; XB-GENE-6254720; osr2.S.
DR   OMA; QMNHWTL; -.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 734939; Expressed in neurula embryo and 12 other tissues.
DR   GO; GO:0005634; C:nucleus; IC:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR   GO; GO:0048793; P:pronephros development; IMP:UniProtKB.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Developmental protein; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..271
FT                   /note="Protein odd-skipped-related 2-A"
FT                   /id="PRO_0000390733"
FT   ZN_FING         172..194
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         200..222
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         228..250
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   271 AA;  30300 MW;  00E0287C9E35D3C4 CRC64;
     MGSKALPAPV PLHPSLQLTN YSFLQAVNTF PAAVDHLQGL YGLSAVQTMH MNHWTLGYPN
     LHGLTRSTIT EMAAAQGLMD ARFSFPALPF ATHLFHPKQG TIAHVIPALH KDRPRFDFAN
     LAIAATQEDP PKIGDLSKLS PGLGSPISEI SKLSPDRKPS RGRLPSKTKK EFICKFCGRH
     FTKSYNLLIH ERTHTDERPY TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS
     RTLAVHKTLH MQTSSPTVVS SAEKFSGEIA I