ID   OSR2B_XENLA             Reviewed;         271 AA.
AC   Q0IHB8;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Protein odd-skipped-related 2-B;
GN   Name=osr2-b; Synonyms=osr2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAI23223.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAI23223.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor. Required for pronephric kidney
CC       development (By similarity). {ECO:0000250|UniProtKB:Q32NK7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q32NK7}.
CC   -!- SIMILARITY: Belongs to the Odd C2H2-type zinc-finger protein family.
CC       {ECO:0000255}.
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DR   EMBL; BC123222; AAI23223.1; -; mRNA.
DR   RefSeq; NP_001090353.1; NM_001096884.1.
DR   AlphaFoldDB; Q0IHB8; -.
DR   BMRB; Q0IHB8; -.
DR   SMR; Q0IHB8; -.
DR   DNASU; 779263; -.
DR   GeneID; 779263; -.
DR   KEGG; xla:779263; -.
DR   CTD; 779263; -.
DR   Xenbase; XB-GENE-864802; osr2.L.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 779263; Expressed in internal ear and 16 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0048793; P:pronephros development; ISS:UniProtKB.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Developmental protein; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..271
FT                   /note="Protein odd-skipped-related 2-B"
FT                   /id="PRO_0000390734"
FT   ZN_FING         172..194
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         200..222
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         228..250
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   271 AA;  30314 MW;  75BEB41A2B6299A0 CRC64;
     MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PAAVDHLQGL YGLSAVQTMH MNHWTLGYPN
     LHGITRSTIT EMAAAQGLMD ARFSFPALPF ATHLFHPKQG TIAHVIPALH KDRPRFDFAN
     LAIAATQEDP PKIGDLSKLS PGLGSPISEI SKLSPDRKPS RGRLPSKTKK EFICKFCGRH
     FTKSYNLLIH ERTHTDERPY TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS
     RTLAVHKTLH MQTSSPTVVS SAEKFSGEIA I