OSR2_HUMAN
ID OSR2_HUMAN Reviewed; 312 AA.
AC Q8N2R0; A8K626; B4E3B7; Q96AM6; Q96LB6; Q96LB7;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Protein odd-skipped-related 2;
GN Name=OSR2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RA Jiang R., Cho E.-S., Lan Y.;
RT "Isolation of the human OSR2 gene.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Embryo, and Ovary;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N2R0; P25788: PSMA3; NbExp=3; IntAct=EBI-5660512, EBI-348380;
CC Q8N2R0-2; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-12850348, EBI-12111050;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=OSR2A;
CC IsoId=Q8N2R0-1; Sequence=Displayed;
CC Name=2; Synonyms=OSR2B;
CC IsoId=Q8N2R0-2; Sequence=VSP_017121;
CC Name=3;
CC IsoId=Q8N2R0-3; Sequence=VSP_054849;
CC -!- SIMILARITY: Belongs to the Odd C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; AY038072; AAK74066.1; -; mRNA.
DR EMBL; AY038073; AAK74067.1; -; mRNA.
DR EMBL; AK074518; BAC11035.1; -; mRNA.
DR EMBL; AK291491; BAF84180.1; -; mRNA.
DR EMBL; AK304654; BAG65429.1; -; mRNA.
DR EMBL; AC016877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471060; EAW91785.1; -; Genomic_DNA.
DR EMBL; BC016936; AAH16936.1; -; mRNA.
DR CCDS; CCDS47901.1; -. [Q8N2R0-1]
DR CCDS; CCDS47902.1; -. [Q8N2R0-2]
DR CCDS; CCDS69520.1; -. [Q8N2R0-3]
DR RefSeq; NP_001135934.1; NM_001142462.2. [Q8N2R0-1]
DR RefSeq; NP_001273770.1; NM_001286841.1. [Q8N2R0-3]
DR RefSeq; NP_443727.2; NM_053001.3. [Q8N2R0-2]
DR RefSeq; XP_011515129.1; XM_011516827.2. [Q8N2R0-1]
DR RefSeq; XP_016868507.1; XM_017013018.1. [Q8N2R0-1]
DR AlphaFoldDB; Q8N2R0; -.
DR SMR; Q8N2R0; -.
DR BioGRID; 125467; 9.
DR IntAct; Q8N2R0; 3.
DR STRING; 9606.ENSP00000414657; -.
DR iPTMnet; Q8N2R0; -.
DR PhosphoSitePlus; Q8N2R0; -.
DR BioMuta; OSR2; -.
DR DMDM; 146345473; -.
DR MassIVE; Q8N2R0; -.
DR MaxQB; Q8N2R0; -.
DR PaxDb; Q8N2R0; -.
DR PeptideAtlas; Q8N2R0; -.
DR PRIDE; Q8N2R0; -.
DR ProteomicsDB; 71727; -. [Q8N2R0-1]
DR ProteomicsDB; 71728; -. [Q8N2R0-2]
DR Antibodypedia; 26083; 145 antibodies from 29 providers.
DR DNASU; 116039; -.
DR Ensembl; ENST00000297565.9; ENSP00000297565.4; ENSG00000164920.10. [Q8N2R0-1]
DR Ensembl; ENST00000435298.6; ENSP00000402862.2; ENSG00000164920.10. [Q8N2R0-2]
DR Ensembl; ENST00000457907.3; ENSP00000414657.2; ENSG00000164920.10. [Q8N2R0-3]
DR Ensembl; ENST00000522510.5; ENSP00000430780.1; ENSG00000164920.10. [Q8N2R0-1]
DR GeneID; 116039; -.
DR KEGG; hsa:116039; -.
DR MANE-Select; ENST00000297565.9; ENSP00000297565.4; NM_001142462.3; NP_001135934.1.
DR UCSC; uc003yiq.5; human. [Q8N2R0-1]
DR CTD; 116039; -.
DR DisGeNET; 116039; -.
DR GeneCards; OSR2; -.
DR HGNC; HGNC:15830; OSR2.
DR HPA; ENSG00000164920; Tissue enhanced (cervix, endometrium, fallopian tube).
DR MIM; 611297; gene.
DR neXtProt; NX_Q8N2R0; -.
DR OpenTargets; ENSG00000164920; -.
DR PharmGKB; PA134924513; -.
DR VEuPathDB; HostDB:ENSG00000164920; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160530; -.
DR HOGENOM; CLU_051854_0_0_1; -.
DR InParanoid; Q8N2R0; -.
DR OMA; HTPHQDY; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N2R0; -.
DR TreeFam; TF350876; -.
DR PathwayCommons; Q8N2R0; -.
DR SignaLink; Q8N2R0; -.
DR BioGRID-ORCS; 116039; 16 hits in 1107 CRISPR screens.
DR ChiTaRS; OSR2; human.
DR GeneWiki; OSR2_(gene); -.
DR GenomeRNAi; 116039; -.
DR Pharos; Q8N2R0; Tbio.
DR PRO; PR:Q8N2R0; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q8N2R0; protein.
DR Bgee; ENSG00000164920; Expressed in palpebral conjunctiva and 145 other tissues.
DR ExpressionAtlas; Q8N2R0; baseline and differential.
DR Genevisible; Q8N2R0; HS.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:ARUK-UCL.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISS:ARUK-UCL.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0060349; P:bone morphogenesis; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; ISS:BHF-UCL.
DR GO; GO:0002062; P:chondrocyte differentiation; ISS:BHF-UCL.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; ISS:UniProtKB.
DR GO; GO:0042733; P:embryonic digit morphogenesis; ISS:BHF-UCL.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; ISS:BHF-UCL.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; ISS:BHF-UCL.
DR GO; GO:0072498; P:embryonic skeletal joint development; ISS:BHF-UCL.
DR GO; GO:0060272; P:embryonic skeletal joint morphogenesis; ISS:BHF-UCL.
DR GO; GO:0036023; P:embryonic skeletal limb joint morphogenesis; ISS:BHF-UCL.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISS:UniProtKB.
DR GO; GO:0061029; P:eyelid development in camera-type eye; ISS:UniProtKB.
DR GO; GO:0060322; P:head development; ISS:BHF-UCL.
DR GO; GO:0001823; P:mesonephros development; ISS:UniProtKB.
DR GO; GO:0001656; P:metanephros development; ISS:UniProtKB.
DR GO; GO:0042474; P:middle ear morphogenesis; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:BHF-UCL.
DR GO; GO:0042476; P:odontogenesis; ISS:UniProtKB.
DR GO; GO:0033687; P:osteoblast proliferation; ISS:UniProtKB.
DR GO; GO:0030501; P:positive regulation of bone mineralization; ISS:BHF-UCL.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:BHF-UCL.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060021; P:roof of mouth development; ISS:UniProtKB.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR GO; GO:0001655; P:urogenital system development; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..312
FT /note="Protein odd-skipped-related 2"
FT /id="PRO_0000047007"
FT ZN_FING 172..194
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 200..222
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 228..250
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 256..278
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 284..306
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 129..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1
FT /note="M -> MGLRAEEGKRKPPRSVRGEVSPSQGPLAQEDEARRLRSCTPACHPGK
FT RGKGGHRARRQRSAWDLTTHPLTHRSQELRGAAATEGFLYVLLSHWVFVGAPRPPASDS
FT WKKGLVPSAPPASRKM (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054849"
FT VAR_SEQ 253..312
FT /note="ESPHKCPTCGRTFNQRSNLKTHLLTHTDIKPYSCEQCGKVFRRNCDLRRHSL
FT THTPRQDF -> TSSPTAASSAAKCSGETVICGGTA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_017121"
FT CONFLICT 132
FT /note="K -> G (in Ref. 1; AAK74066)"
FT /evidence="ECO:0000305"
FT CONFLICT 286
FT /note="C -> R (in Ref. 2; BAC11035)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 35513 MW; 312E5A688EFB88B6 CRC64;
MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PATVDHLQGL YGLSAVQTMH MNHWTLGYPN
VHEITRSTIT EMAAAQGLVD ARFPFPALPF TTHLFHPKQG AIAHVLPALH KDRPRFDFAN
LAVAATQEDP PKMGDLSKLS PGLGSPISGL SKLTPDRKPS RGRLPSKTKK EFICKFCGRH
FTKSYNLLIH ERTHTDERPY TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS
RTLAVHKTLH MQESPHKCPT CGRTFNQRSN LKTHLLTHTD IKPYSCEQCG KVFRRNCDLR
RHSLTHTPRQ DF
