OSR2_RAT
ID OSR2_RAT Reviewed; 276 AA.
AC Q6AY34;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Protein odd-skipped-related 2;
GN Name=Osr2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Odd C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; BC079211; AAH79211.1; -; mRNA.
DR RefSeq; NP_001012118.1; NM_001012118.1.
DR AlphaFoldDB; Q6AY34; -.
DR BMRB; Q6AY34; -.
DR SMR; Q6AY34; -.
DR STRING; 10116.ENSRNOP00000014879; -.
DR PhosphoSitePlus; Q6AY34; -.
DR PaxDb; Q6AY34; -.
DR PRIDE; Q6AY34; -.
DR Ensembl; ENSRNOT00000014879; ENSRNOP00000014879; ENSRNOG00000011136.
DR GeneID; 315039; -.
DR KEGG; rno:315039; -.
DR UCSC; RGD:1305812; rat.
DR CTD; 116039; -.
DR RGD; 1305812; Osr2.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160530; -.
DR HOGENOM; CLU_051854_0_0_1; -.
DR InParanoid; Q6AY34; -.
DR OMA; QMNHWTL; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6AY34; -.
DR TreeFam; TF350876; -.
DR PRO; PR:Q6AY34; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000011136; Expressed in ovary and 11 other tissues.
DR Genevisible; Q6AY34; RN.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0060349; P:bone morphogenesis; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; ISO:RGD.
DR GO; GO:0002062; P:chondrocyte differentiation; ISO:RGD.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; ISS:UniProtKB.
DR GO; GO:0042733; P:embryonic digit morphogenesis; ISO:RGD.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; ISO:RGD.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; ISO:RGD.
DR GO; GO:0072498; P:embryonic skeletal joint development; ISO:RGD.
DR GO; GO:0060272; P:embryonic skeletal joint morphogenesis; ISO:RGD.
DR GO; GO:0036023; P:embryonic skeletal limb joint morphogenesis; ISO:RGD.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISS:UniProtKB.
DR GO; GO:0061029; P:eyelid development in camera-type eye; ISS:UniProtKB.
DR GO; GO:0060322; P:head development; ISO:RGD.
DR GO; GO:0001823; P:mesonephros development; ISS:UniProtKB.
DR GO; GO:0001656; P:metanephros development; ISS:UniProtKB.
DR GO; GO:0042474; P:middle ear morphogenesis; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0042476; P:odontogenesis; ISS:UniProtKB.
DR GO; GO:0033687; P:osteoblast proliferation; ISS:UniProtKB.
DR GO; GO:0030501; P:positive regulation of bone mineralization; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:UniProtKB.
DR GO; GO:2000543; P:positive regulation of gastrulation; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0048793; P:pronephros development; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060021; P:roof of mouth development; ISS:UniProtKB.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR GO; GO:0001655; P:urogenital system development; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..276
FT /note="Protein odd-skipped-related 2"
FT /id="PRO_0000047009"
FT ZN_FING 172..194
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 200..222
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 228..250
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 129..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 276 AA; 30513 MW; 5BFBC932B42B3ED6 CRC64;
MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PAAVDHLQGL YGLSAVQTMH MNHWTLGYPN
VHEITRSTIT EMAAAQGLVD ARFPFPALPF ATHLFHPKQG AIAHVLPALH KDRPRFDFAN
LAVAATQEDP PKMGDLSKLS PGLGSPISGL SKLTPDRKPS RGRLPSKTKK EFICKFCGRH
FTKSYNLLIH ERTHTDERPY TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS
RTLAVHKTLH MQTSSPTAAS SAAKCSGETV ICGGTA
