OSTA2_CAEEL
ID OSTA2_CAEEL Reviewed; 342 AA.
AC Q18071; Q8IG51; Q95QV9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Organic solute transporter alpha-like protein 2;
DE AltName: Full=Solute carrier family 51 subunit alpha homolog A;
GN Name=osta-2; ORFNames=C18A3.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Probable transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a;
CC IsoId=Q18071-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q18071-2; Sequence=VSP_033258;
CC Name=c;
CC IsoId=Q18071-3; Sequence=VSP_033257;
CC -!- SIMILARITY: Belongs to the OST-alpha family. {ECO:0000305}.
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DR EMBL; FO080599; CCD65012.1; -; Genomic_DNA.
DR EMBL; FO080599; CCD65013.1; -; Genomic_DNA.
DR EMBL; FO080599; CCD65014.1; -; Genomic_DNA.
DR PIR; T15541; T15541.
DR RefSeq; NP_741003.1; NM_171004.4. [Q18071-1]
DR AlphaFoldDB; Q18071; -.
DR STRING; 6239.C18A3.4a.1; -.
DR TCDB; 2.A.82.1.4; the organic solute transporter (ost) family.
DR PaxDb; Q18071; -.
DR EnsemblMetazoa; C18A3.4a.1; C18A3.4a.1; WBGene00015942. [Q18071-1]
DR EnsemblMetazoa; C18A3.4a.2; C18A3.4a.2; WBGene00015942. [Q18071-1]
DR GeneID; 173966; -.
DR KEGG; cel:CELE_C18A3.4; -.
DR UCSC; C18A3.4a; c. elegans. [Q18071-1]
DR CTD; 173966; -.
DR WormBase; C18A3.4a; CE01796; WBGene00015942; osta-2. [Q18071-1]
DR eggNOG; KOG2641; Eukaryota.
DR HOGENOM; CLU_061874_0_0_1; -.
DR InParanoid; Q18071; -.
DR OMA; DAIWINC; -.
DR OrthoDB; 984421at2759; -.
DR PhylomeDB; Q18071; -.
DR PRO; PR:Q18071; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00015942; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR005178; Ostalpha/TMEM184C.
DR PANTHER; PTHR23423; PTHR23423; 1.
DR Pfam; PF03619; Solute_trans_a; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..342
FT /note="Organic solute transporter alpha-like protein 2"
FT /id="PRO_0000331548"
FT TOPO_DOM 1..50
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..79
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..176
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..208
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..290
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 312..342
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 206..342
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_033257"
FT VAR_SEQ 287..342
FT /note="YWKNFFTVIEAFCVTLISTVLLQPSKSSFFDKHPSCRSMSSARSTITDVDTD
FT ESTT -> CEFELNITQMRSFCDFCARSRRENFLLNARRCSPLKSTVIPNFRCCGIFID
FT FS (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_033258"
SQ SEQUENCE 342 AA; 38831 MW; A0B8C89F64AFF034 CRC64;
MLEISPWETL VKLLTDSLLN CTGTHEDVPH AKTFLRSLTT TYIASLAVAT AVTVGTVCLA
VLHLIYIHFY ITHSSRRLHI VLLACTAPLV SLLALVAMYM PRVWFLSHLL SFLYFSFALW
VIICLLLHIF DGHHALVTKM MQRLQYVEIA TPPFCCLFPC LPKVRLEGKK IRWCELMVMQ
APIVRLFATL VSLVIYFEYQ DQGLVPLKVL DFITLPSLLA GIYGTHILVT TVSRMDELIS
YRYVVVFRLL DFFFMVFGLQ QPVFDFLARY GAFGCGTVLP AIETSFYWKN FFTVIEAFCV
TLISTVLLQP SKSSFFDKHP SCRSMSSARS TITDVDTDES TT
