ID   OSTA3_CAEEL             Reviewed;         348 AA.
AC   Q9XU63;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Organic solute transporter alpha-like protein 3;
DE   AltName: Full=Solute carrier family 51 subunit alpha homolog B;
GN   Name=osta-3; ORFNames=W01D2.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Probable transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OST-alpha family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z83128; CAB05639.1; -; Genomic_DNA.
DR   PIR; T26059; T26059.
DR   RefSeq; NP_497071.1; NM_064670.4.
DR   AlphaFoldDB; Q9XU63; -.
DR   IntAct; Q9XU63; 1.
DR   STRING; 6239.W01D2.5a.1; -.
DR   PaxDb; Q9XU63; -.
DR   EnsemblMetazoa; W01D2.5a.1; W01D2.5a.1; WBGene00012182.
DR   EnsemblMetazoa; W01D2.5a.2; W01D2.5a.2; WBGene00012182.
DR   GeneID; 175140; -.
DR   KEGG; cel:CELE_W01D2.5; -.
DR   UCSC; W01D2.5; c. elegans.
DR   CTD; 175140; -.
DR   WormBase; W01D2.5a; CE20128; WBGene00012182; osta-3.
DR   eggNOG; KOG2641; Eukaryota.
DR   InParanoid; Q9XU63; -.
DR   OMA; YLEDAVY; -.
DR   OrthoDB; 1345827at2759; -.
DR   PhylomeDB; Q9XU63; -.
DR   SignaLink; Q9XU63; -.
DR   PRO; PR:Q9XU63; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00012182; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q9XU63; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005178; Ostalpha/TMEM184C.
DR   PANTHER; PTHR23423; PTHR23423; 1.
DR   Pfam; PF03619; Solute_trans_a; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..348
FT                   /note="Organic solute transporter alpha-like protein 3"
FT                   /id="PRO_0000331549"
FT   TOPO_DOM        1..49
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..84
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        106..109
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        131..180
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        202..213
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..240
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        262..291
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        313..348
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        26
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   348 AA;  39464 MW;  5D62C98702F744B5 CRC64;
     MAKEHGAMRS VLNLIGSVML PQDTSNCSDR HDTPSAPEFL SHLQPFQTVL LSIASFSTTI
     VLCLSLIHWF YVYKYVSIEK RRNKLYWLIA VFPVACSCSF IAMCVPRTAV ILTCIGVLYY
     LMCLFVIVSL ARHLFGGRES FSTCLQYDDR PIDFRSPPFC CIIPKLPTAR STEKNIRRLE
     WCVLQAPIVR SIIIFLDVVA VAEMREDATP YIRYSDMASL CSLLLAIFGV HTLARVTSNK
     LSAYCFMSMF RLVDISLLFF SAQQPMIFQN VLLRFNLISC GPLLNAQENA YFVCNFIITC
     EMLLLSVLAT WLLAPRHNAM FDAYRPSMAL SETTASLNET EQSMILDH