ID   ASC11_DIDFA             Reviewed;         573 AA.
AC   A0A5C1RF03;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2019, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Ascochitine biosynthesis cluster transcriptional regulator {ECO:0000303|PubMed:31554725};
DE   AltName: Full=Ascochitine biosynthesis cluster protein 11 {ECO:0000303|PubMed:31554725};
GN   ORFNames=orf11 {ECO:0000303|PubMed:31554725};
OS   Didymella fabae (Leaf and pod spot disease fungus) (Ascochyta fabae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Didymellaceae; Ascochyta.
OX   NCBI_TaxID=372025;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=AF247/15;
RX   PubMed=31554725; DOI=10.1128/msphere.00622-19;
RA   Kim W., Lichtenzveig J., Syme R.A., Williams A.H., Peever T.L., Chen W.;
RT   "Identification of a polyketide synthase gene responsible for ascochitine
RT   biosynthesis in Ascochyta fabae and its abrogation in sister taxa.";
RL   MSphere 4:0-0(2019).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of the mycotoxin
CC       ascochitine, an o-quinone methide that plays a possible protective role
CC       against other microbial competitors in nature and is considered to be
CC       important for pathogenicity of legume-associated Didymella species.
CC       {ECO:0000305|PubMed:31554725}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255}.
CC   -!- CAUTION: The deduced amino acid sequence of the orf11 gene lacks a DNA-
CC       binding domain and contains only the conserved domain (termed 'middle
CC       homology region') that is commonly found in Zn(II)2Cys6-type
CC       transcription factors. {ECO:0000269|PubMed:31554725}.
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DR   EMBL; MN052632; QEN17979.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A5C1RF03; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   SMART; SM00906; Fungal_trans; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Virulence; Zinc.
FT   CHAIN           1..573
FT                   /note="Ascochitine biosynthesis cluster transcriptional
FT                   regulator"
FT                   /id="PRO_0000448996"
SQ   SEQUENCE   573 AA;  65361 MW;  C06302821B3BB061 CRC64;
     MAALRKRIAE LEGRLASQEP AEREEHEEVT HNILDFPGDD HLPDWNDFNN MSLPTSNNTS
     VGDTETSFSN FIASTTAQSM PMTMASLTST PVTTASLTTA ALMPVVPLTP ATTVSIATPQ
     LHTLSGFIPA ELDQLYFERV HPAIPLLHQR TYLSWSRKDI KKKSQLCLQH AMWTLAALQS
     AQYRYLQETL YRSCTQMLTS ICLSDSGQDP FDTEQIQAWL LITVYELMRS FHRQAWMSVG
     RAFRLLQLLR YHELDNPALG IPAGQDFIER EEQRRAFWMA YVLDHLFGVS NNWPITLNEL
     VVCTRLPAFE EDFQSERPVL GSFLSEAITE QTPRYLSAFN ETIIFATLCG RRLFYGQQFH
     VRSAYGDMYS NWSNSTLMLD NILRQRVDIL SQCYPPLDEA SGPMMHFVST MAQCSIIYSC
     TGADMMLRVD EGNAAMQTEY ALRAATAAEH VIRLAQMLTR CFVFKVLSFS PPSFTTQHRH
     TSEKKYTLTR RQQIHPLASI PLMLCAEFLF KNQNVSEKFA TLLERLLKEF EQIRDIEDPA
     QSYIDVMKRW QCSAKNSDRQ QRQPSVDSAA LSA