ID   OSTCB_XENLA             Reviewed;         149 AA.
AC   Q5M9B7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Oligosaccharyltransferase complex subunit ostc-B {ECO:0000250|UniProtKB:Q9NRP0};
GN   Name=ostc-b {ECO:0000250|UniProtKB:Q9NRP0};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specific component of the STT3A-containing form of the
CC       oligosaccharyl transferase (OST) complex that catalyzes the initial
CC       transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from
CC       the lipid carrier dolichol-pyrophosphate to an asparagine residue
CC       within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains,
CC       the first step in protein N-glycosylation. N-glycosylation occurs
CC       cotranslationally and the complex associates with the Sec61 complex at
CC       the channel-forming translocon complex that mediates protein
CC       translocation across the endoplasmic reticulum (ER). All subunits are
CC       required for a maximal enzyme activity. {ECO:0000250|UniProtKB:Q9NRP0}.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000250|UniProtKB:Q9NRP0}.
CC   -!- SUBUNIT: Specific component of the STT3A-containing form of the
CC       oligosaccharyltransferase (OST) complex.
CC       {ECO:0000250|UniProtKB:P86218}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the OSTC family. {ECO:0000305}.
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DR   EMBL; BC087303; AAH87303.1; -; mRNA.
DR   RefSeq; NP_001088833.1; NM_001095364.1.
DR   RefSeq; XP_018094464.1; XM_018238975.1.
DR   RefSeq; XP_018094475.1; XM_018238986.1.
DR   RefSeq; XP_018094482.1; XM_018238993.1.
DR   RefSeq; XP_018094491.1; XM_018239002.1.
DR   AlphaFoldDB; Q5M9B7; -.
DR   SMR; Q5M9B7; -.
DR   MaxQB; Q5M9B7; -.
DR   DNASU; 496140; -.
DR   GeneID; 496140; -.
DR   KEGG; xla:496140; -.
DR   CTD; 496140; -.
DR   Xenbase; XB-GENE-974369; ostc.S.
DR   OMA; WIFMRMK; -.
DR   OrthoDB; 1575260at2759; -.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 496140; Expressed in oocyte and 20 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008250; C:oligosaccharyltransferase complex; IEA:InterPro.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR021149; OligosaccharylTrfase_OST3/OST6.
DR   InterPro; IPR042416; OSTC.
DR   PANTHER; PTHR13160; PTHR13160; 1.
DR   Pfam; PF04756; OST3_OST6; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..149
FT                   /note="Oligosaccharyltransferase complex subunit ostc-B"
FT                   /id="PRO_0000320607"
FT   TOPO_DOM        1..32
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        54..83
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..117
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        139..149
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   149 AA;  16825 MW;  494D875B068DD81C CRC64;
     MESLYRIPFT VLECPNLKLK KPSWLHMPSA MTVYAMVVVS YFLITGGIIY DVIVEPPSVG
     SMTDEHGHQR PVAFLAYRVN GQYIMEGLAS SFLFTMGGLG FIILDRSNAP NIPKLNRFLL
     LFIGFVCVLL SFFMARVFMR MKLPGYLMG