ID   OSTCN_HOMNE             Reviewed;          24 AA.
AC   P84351;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Osteocalcin;
DE   AltName: Full=Bone Gla protein;
DE            Short=BGP;
DE   AltName: Full=Gamma-carboxyglutamic acid-containing protein;
DE   Flags: Fragment;
GN   Name=BGLAP {ECO:0000250|UniProtKB:P02819};
OS   Homo sapiens neanderthalensis (Neanderthal).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=63221;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE.
RC   TISSUE=Bone {ECO:0000269|PubMed:15753298};
RX   PubMed=15753298; DOI=10.1073/pnas.0500450102;
RA   Nielsen-Marsh C.M., Richards M.P., Hauschka P.V., Thomas-Oates J.E.,
RA   Trinkaus E., Pettit P.B., Karavanic I., Poinar H., Collins M.J.;
RT   "Osteocalcin protein sequences of Neanderthals and modern primates.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:4409-4413(2005).
CC   -!- FUNCTION: Constitutes 1-2% of the total bone protein. It binds strongly
CC       to apatite and calcium. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- PTM: Gamma-carboxyglutamate residues are formed by vitamin K dependent
CC       carboxylation. These residues are essential for the binding of calcium.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P84351; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
DR   InterPro; IPR035972; GLA-like_dom_SF.
DR   InterPro; IPR000294; GLA_domain.
DR   SUPFAM; SSF57630; SSF57630; 1.
DR   PROSITE; PS50998; GLA_2; 1.
PE   1: Evidence at protein level;
KW   Biomineralization; Calcium; Direct protein sequencing; Disulfide bond;
KW   Extinct organism protein; Gamma-carboxyglutamic acid; Metal-binding;
KW   Secreted.
FT   CHAIN           <1..>24
FT                   /note="Osteocalcin"
FT                   /id="PRO_0000148899"
FT   DOMAIN          <1..>24
FT                   /note="Gla"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT   BINDING         2
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         5
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         5
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         11
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250|UniProtKB:P83489,
FT                   ECO:0000255|PROSITE-ProRule:PRU00463"
FT   MOD_RES         5
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250|UniProtKB:P83489,
FT                   ECO:0000255|PROSITE-ProRule:PRU00463"
FT   DISULFID        4..10
FT                   /evidence="ECO:0000250|UniProtKB:P02819,
FT                   ECO:0000255|PROSITE-ProRule:PRU00463"
FT   NON_TER         1
FT                   /evidence="ECO:0000303|PubMed:15753298"
FT   NON_TER         24
FT                   /evidence="ECO:0000303|PubMed:15753298"
SQ   SEQUENCE   24 AA;  2823 MW;  4882FA3A71F29E89 CRC64;
     REVCELNPDC DELADHIGFQ EAYR