ID   A2MG_RALSO              Reviewed;        1582 AA.
AC   Q8XV02;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Alpha-2-macroglobulin {ECO:0000250|UniProtKB:P76578};
DE   Flags: Precursor;
GN   OrderedLocusNames=RSc3030; ORFNames=RS04727;
OS   Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=267608;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GMI1000;
RX   PubMed=11823852; DOI=10.1038/415497a;
RA   Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M.,
RA   Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M.,
RA   Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M.,
RA   Moisan A., Robert C., Saurin W., Schiex T., Siguier P., Thebault P.,
RA   Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A.;
RT   "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL   Nature 415:497-502(2002).
CC   -!- FUNCTION: Protects the bacterial cell from host peptidases.
CC       {ECO:0000250|UniProtKB:P76578}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL646052; CAD16739.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8XV02; -.
DR   SMR; Q8XV02; -.
DR   STRING; 267608.RSc3030; -.
DR   MEROPS; I39.008; -.
DR   EnsemblBacteria; CAD16739; CAD16739; RSc3030.
DR   KEGG; rso:RSc3030; -.
DR   eggNOG; COG2373; Bacteria.
DR   HOGENOM; CLU_004561_0_0_4; -.
DR   OMA; YAYYADW; -.
DR   Proteomes; UP000001436; Chromosome.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SUPFAM; SSF48239; SSF48239; 1.
PE   3: Inferred from homology;
KW   Protease inhibitor; Reference proteome; Signal; Thioester bond.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..1582
FT                   /note="Alpha-2-macroglobulin"
FT                   /id="PRO_0000036243"
FT   CROSSLNK        1080..1083
FT                   /note="Isoglutamyl cysteine thioester (Cys-Gln)"
FT                   /evidence="ECO:0000250|UniProtKB:P76578"
SQ   SEQUENCE   1582 AA;  170091 MW;  8683D148F5AE3C2A CRC64;
     MICLAALAVA VPARADEAAA VRDKPNPTLA EVPASGYVPF TGQPFFLLSD ASYGTDQEAM
     VRLEAPGREY KDELARYGGA DILVYRVPQP LDFLKAQKNL HRIDVKANYT GEGLANTLAY
     LWDNWTRQAR RAWQRVLSFA TRSKAVEAAP QFSMGDQMAA PTRFSNPPQY APLKGYELLG
     RFRYPIWEAK PIAPPKDVKL EGSSSEWMPQ NVGNVMIPVG KLPAGLYIVE AVIGAYRAHT
     LLFVSDTVAV TKGTSQGMMV WTAERKSGKP VAGSAVSWTD GVGVLASGTT QADGTAELRH
     VAPERSYVLG VDRAGGVFIS ENFYYDSEIY NTKLYAFTDR PLYRPGDDVR VKFIGRNFRS
     ATESTAPAAG DIKLDVIDPT GAPVATTTTR LSGETGADAR FTLPSNAQAG GYTLRFDYGG
     STYGGAFRVA EYIKPHFDVN LSLDKAGYGT GEAIKGKISL RYPDGKPVKD GKVSVSLRAQ
     QVTMVEGELQ YAGLFPVKLE QQELTTDGDG NAALTLPAAK EPSRYVVTVF ANDGAAYRVK
     VTRELLVARG AAPYRLSTAA NFTTPGQSVS FNLQPLPAVD GVRGASAPPA KWELVRLESR
     TRTEGALQPD AKGSATFPVK FEQPGSYTLS VRDAAGNLLA ASSHWVAGDG VQTVPGNIEI
     VFDRDRYQIG DTAEALITFP QPVDDALLTL ERDKVERHAL LSGGGDWLAL QRVTPSQYRA
     RIKIGAEFSP NMTFSALTVR DGDMVFQNAG IVVTQPALDL TVRADKAVYA PGETVTLDLS
     SALAGKPVPA NLTVSVVDEM VYVLQPEVAP SIVDFFYHPR RNSVRTTSSQ SFISYDLALS
     SLPGKPGGTY GRHNERGVKV LERPRRDEQD TAAWVANLQT GADGRARMTF TMPDSLARWR
     VTVRAVSTTG AADGIVGQRT ASIRSDKALY LKWTGPSRFR ESDQPRLDMV AFNQTDKDIT
     ADWIVSGAGL NINQRVTLKR GANYLHAPLS GTPALQAGIV NAELKQDDRV SDRLQTTVKL
     DATGWLADRE SIVPLTQLQG TRLPLGLPAD ARDVRLRVVG NTASQFARVA DDLIEYPYGC
     AEQTASRLIP LALAQQSLAA TGARLPDGNP AGTQGVDALL RTQRQRLALL AGTNGTFGWW
     GELTSSSALI TSYAYYADWL ASRAVGISLP ADNWKQVLEA YKRTSQNEPL LHRALALWFA
     NEMGLPVATP LSGVAAELAR NAKAPADAEP APGDSLIFVA PDSPRGRQVA AILTAQLMRQ
     VGQPVPEALV SADIAARTAL ANDTSPLVQS LLLMGGGRSA ADPAPLLARA SAAMPTMDRA
     VALVWLQKGL GGLQGANVAA IQPVLSAGGW QAARSTVGVP TWRWAGAQPP AALDLASTPS
     DVTTQSAIVS YRSRAPEASR LPITVERKLY RLEPVDAAAP KDDAKAPKRA AADVTANAGI
     TFKAKPVKPG DTLDSNALYV DEVVLTPRQG TYRYGLVEVP LPPGAEVEAT TWGIQIDGLK
     GEPNEGNGPQ PFERRAAYEM GQLSYNQPVP TLERPTALRQ LVRFSLPGRF ALPPARYFRM
     YQPEAKALQG DGKAASYPFK VE