ID   OSTC_BOVIN              Reviewed;         149 AA.
AC   Q2KID7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Oligosaccharyltransferase complex subunit OSTC {ECO:0000250|UniProtKB:Q9NRP0};
GN   Name=OSTC {ECO:0000250|UniProtKB:Q9NRP0};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specific component of the STT3A-containing form of the
CC       oligosaccharyl transferase (OST) complex that catalyzes the initial
CC       transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from
CC       the lipid carrier dolichol-pyrophosphate to an asparagine residue
CC       within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains,
CC       the first step in protein N-glycosylation. N-glycosylation occurs
CC       cotranslationally and the complex associates with the Sec61 complex at
CC       the channel-forming translocon complex that mediates protein
CC       translocation across the endoplasmic reticulum (ER). All subunits are
CC       required for a maximal enzyme activity. May be involved in N-
CC       glycosylation of APP (amyloid-beta precursor protein). Can modulate
CC       gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.
CC       {ECO:0000250|UniProtKB:Q9NRP0}.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000250|UniProtKB:Q9NRP0}.
CC   -!- SUBUNIT: Specific component of the STT3A-containing form of the
CC       oligosaccharyltransferase (OST) complex (By similarity). OST exists in
CC       two different complex forms which contain common core subunits RPN1,
CC       RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic
CC       subunits, and form-specific accessory subunits (By similarity). STT3A
CC       complex assembly occurs through the formation of 3 subcomplexes.
CC       Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the
CC       STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core
CC       subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The
CC       STT3A complex can form stable complexes with the Sec61 complex or with
CC       both the Sec61 and TRAP complexes (By similarity). Interacts with PSEN1
CC       and NCSTN; indicative for an association with the gamma-secretase
CC       complex (By similarity). {ECO:0000250|UniProtKB:P86218,
CC       ECO:0000250|UniProtKB:Q9NRP0}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q9NRP0}. Membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the OSTC family. {ECO:0000305}.
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DR   EMBL; BC112676; AAI12677.1; -; mRNA.
DR   RefSeq; NP_001070560.1; NM_001077092.1.
DR   AlphaFoldDB; Q2KID7; -.
DR   SMR; Q2KID7; -.
DR   STRING; 9913.ENSBTAP00000050205; -.
DR   PaxDb; Q2KID7; -.
DR   PeptideAtlas; Q2KID7; -.
DR   PRIDE; Q2KID7; -.
DR   Ensembl; ENSBTAT00000035535; ENSBTAP00000050205; ENSBTAG00000011611.
DR   GeneID; 768033; -.
DR   KEGG; bta:768033; -.
DR   CTD; 58505; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011611; -.
DR   VGNC; VGNC:32478; OSTC.
DR   eggNOG; KOG3356; Eukaryota.
DR   GeneTree; ENSGT00390000001376; -.
DR   HOGENOM; CLU_109136_1_0_1; -.
DR   InParanoid; Q2KID7; -.
DR   OMA; WIFMRMK; -.
DR   OrthoDB; 1575260at2759; -.
DR   TreeFam; TF323315; -.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000009136; Chromosome 6.
DR   Bgee; ENSBTAG00000011611; Expressed in abomasum and 107 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008250; C:oligosaccharyltransferase complex; IBA:GO_Central.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR021149; OligosaccharylTrfase_OST3/OST6.
DR   InterPro; IPR042416; OSTC.
DR   PANTHER; PTHR13160; PTHR13160; 1.
DR   Pfam; PF04756; OST3_OST6; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..149
FT                   /note="Oligosaccharyltransferase complex subunit OSTC"
FT                   /id="PRO_0000320601"
FT   TOPO_DOM        1..32
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        54..83
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..117
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        139..149
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   149 AA;  16769 MW;  F9F85880A53F08A5 CRC64;
     MESLYRVPFL VLECPNLKLK KPPWVHMPSA MTVYALVVVS YFLITGGIIY DVIVEPPSVG
     SVTDEHGHQR PVAFLAYRVN GQYIMEGLAS SFLFTMGGLG FIILDRSNAP NIPKLNRFLL
     LFIGFVCVLL SFFMARVFMR MKLPGYLMG