ID   OSTF1_BOVIN             Reviewed;         214 AA.
AC   Q8MJ50;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Osteoclast-stimulating factor 1;
GN   Name=OSTF1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Guo J.H.;
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Induces bone resorption, acting probably through a signaling
CC       cascade which results in the secretion of factor(s) enhancing
CC       osteoclast formation and activity. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SRC and SMN1. Interacts with FASLG (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The SH3 domain mediates interaction with SMN1. {ECO:0000250}.
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DR   EMBL; AF523267; AAM82160.1; -; mRNA.
DR   EMBL; BC112669; AAI12670.1; -; mRNA.
DR   RefSeq; NP_776834.1; NM_174409.2.
DR   AlphaFoldDB; Q8MJ50; -.
DR   SMR; Q8MJ50; -.
DR   STRING; 9913.ENSBTAP00000003560; -.
DR   PaxDb; Q8MJ50; -.
DR   PeptideAtlas; Q8MJ50; -.
DR   PRIDE; Q8MJ50; -.
DR   Ensembl; ENSBTAT00000003560; ENSBTAP00000003560; ENSBTAG00000002746.
DR   GeneID; 281961; -.
DR   KEGG; bta:281961; -.
DR   CTD; 26578; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002746; -.
DR   VGNC; VGNC:32479; OSTF1.
DR   eggNOG; ENOG502QTZB; Eukaryota.
DR   GeneTree; ENSGT00920000149159; -.
DR   HOGENOM; CLU_092255_0_0_1; -.
DR   InParanoid; Q8MJ50; -.
DR   OMA; NMSWLRE; -.
DR   OrthoDB; 1453481at2759; -.
DR   TreeFam; TF314534; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000002746; Expressed in monocyte and 105 other tissues.
DR   ExpressionAtlas; Q8MJ50; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; ANK repeat; Cytoplasm; Phosphoprotein; Reference proteome;
KW   Repeat; SH3 domain.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q92882"
FT   CHAIN           2..214
FT                   /note="Osteoclast-stimulating factor 1"
FT                   /id="PRO_0000238954"
FT   DOMAIN          12..71
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REPEAT          72..101
FT                   /note="ANK 1"
FT   REPEAT          105..135
FT                   /note="ANK 2"
FT   REPEAT          139..168
FT                   /note="ANK 3"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q92882"
FT   MOD_RES         202
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q92882"
FT   MOD_RES         213
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q92882"
SQ   SEQUENCE   214 AA;  23842 MW;  20E051518D032A3C CRC64;
     MSKPPPKPVK PGQVKVFRAL YTFEPRTPDE LYFEEGDIIY ITDMSDTNWW KGTCKGRTGL
     IPSNYVAEQA ESIDNPLHEA AKRGNLSWLR ECLDNRVGVN GLDKAGSTAL YWACHGGHRD
     IVEMLFTQPN IELNQQNKLG DTALHAAAWK GYADIVQLLL EKGARTDLRN NEKKLALDMA
     TNAACASLLK KKQGTDAVRS LSNAEDYLDD EDSD