ID   OSTF1_CHICK             Reviewed;         202 AA.
AC   Q5ZJJ9;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Osteoclast-stimulating factor 1;
GN   Name=OSTF1; ORFNames=RCJMB04_17j8;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Induces bone resorption, acting probably through a signaling
CC       cascade which results in the secretion of factor(s) enhancing
CC       osteoclast formation and activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AJ720435; CAG32094.1; -; mRNA.
DR   AlphaFoldDB; Q5ZJJ9; -.
DR   SMR; Q5ZJJ9; -.
DR   STRING; 9031.ENSGALP00000028084; -.
DR   PaxDb; Q5ZJJ9; -.
DR   VEuPathDB; HostDB:geneid_427258; -.
DR   eggNOG; ENOG502QTZB; Eukaryota.
DR   InParanoid; Q5ZJJ9; -.
DR   PhylomeDB; Q5ZJJ9; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Cytoplasm; Reference proteome; Repeat; SH3 domain.
FT   CHAIN           1..202
FT                   /note="Osteoclast-stimulating factor 1"
FT                   /id="PRO_0000238957"
FT   DOMAIN          12..71
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REPEAT          72..101
FT                   /note="ANK 1"
FT   REPEAT          105..135
FT                   /note="ANK 2"
FT   REPEAT          139..168
FT                   /note="ANK 3"
SQ   SEQUENCE   202 AA;  22296 MW;  7CBF9C11CB4A43E2 CRC64;
     MSKPPPKPAK PGQVKVFRAL YTFEPRTPDE LYFEEGDIIY ISDMSDTNWW KGTCKGRTGL
     IPSNYVAEQA ESIDNPLHEA AKRGNLSWLR ECLDNQVGVN GLDKAGNTAL YWACHGGHKD
     IVDVLFTQAN LELNQQNKLG DTALHAAAWK GYADIVEMLL AKGARTDLKN NEKKLALDMA
     TNAACASLLK KKQTAGTART FK