ID   OSTF1_DANRE             Reviewed;         214 AA.
AC   Q6TGW5;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Osteoclast-stimulating factor 1;
GN   Name=ostf1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
CC   -!- FUNCTION: Induces bone resorption, acting probably through a signaling
CC       cascade which results in the secretion of factor(s) enhancing
CC       osteoclast formation and activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AY398391; AAQ97824.1; -; mRNA.
DR   RefSeq; NP_998022.1; NM_212857.2.
DR   RefSeq; XP_009299439.1; XM_009301164.2.
DR   AlphaFoldDB; Q6TGW5; -.
DR   SMR; Q6TGW5; -.
DR   STRING; 7955.ENSDARP00000066307; -.
DR   PaxDb; Q6TGW5; -.
DR   Ensembl; ENSDART00000157402; ENSDARP00000136330; ENSDARG00000091555.
DR   Ensembl; ENSDART00000168698; ENSDARP00000133534; ENSDARG00000091555.
DR   GeneID; 405783; -.
DR   KEGG; dre:405783; -.
DR   CTD; 26578; -.
DR   ZFIN; ZDB-GENE-040625-157; ostf1.
DR   eggNOG; ENOG502QTZB; Eukaryota.
DR   GeneTree; ENSGT00920000149159; -.
DR   HOGENOM; CLU_092255_0_0_1; -.
DR   InParanoid; Q6TGW5; -.
DR   OMA; NMSWLRE; -.
DR   OrthoDB; 1453481at2759; -.
DR   PhylomeDB; Q6TGW5; -.
DR   TreeFam; TF314534; -.
DR   Reactome; R-DRE-6798695; Neutrophil degranulation.
DR   PRO; PR:Q6TGW5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000091555; Expressed in granulocyte and 20 other tissues.
DR   ExpressionAtlas; Q6TGW5; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Cytoplasm; Reference proteome; Repeat; SH3 domain.
FT   CHAIN           1..214
FT                   /note="Osteoclast-stimulating factor 1"
FT                   /id="PRO_0000238958"
FT   DOMAIN          12..71
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REPEAT          72..101
FT                   /note="ANK 1"
FT   REPEAT          105..135
FT                   /note="ANK 2"
FT   REPEAT          139..168
FT                   /note="ANK 3"
SQ   SEQUENCE   214 AA;  23837 MW;  57E7B21475FA07F3 CRC64;
     MSKPPPKPAK PGQVKVYRAL FTFDPRTPDE LYFEEGDILY ISDTSDSNWW KGTCRGRTGL
     IPSNYVAEQA ESIDNPMHEA AKRGNLSWLR ECLDNKVGIN GLDKAGNTSL YWACHGGHKD
     VVEILLSQPN CELNQQNKLG DTPLHAAAWK GYSDIVEMLL NKNARTDVVN NEKKTALDMA
     TNAQCASLLK RKLGGVILRT HSNAEEYLDD EDSD