ID   OSTF1_MONAL             Reviewed;         214 AA.
AC   Q6XJU9;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Osteoclast-stimulating factor 1;
DE   AltName: Full=Osteoclast-stimulating factor-like;
GN   Name=ostf1; Synonyms=osf;
OS   Monopterus albus (Swamp eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Synbranchidae; Monopterus.
OX   NCBI_TaxID=43700;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=15054860; DOI=10.1002/jez.b.20008;
RA   Xia L., Cheng H., Yu H., Guo Y., Zhou R.;
RT   "Molecular cloning and expression of the osteoclast-stimulating-factor-like
RT   gene from the rice field eel.";
RL   J. Exp. Zool. B Mol. Dev. Evol. 302:174-181(2004).
CC   -!- FUNCTION: Induces bone resorption, acting probably through a signaling
CC       cascade which results in the secretion of factor(s) enhancing
CC       osteoclast formation and activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC       {ECO:0000269|PubMed:15054860}.
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DR   EMBL; AY230261; AAP55655.1; -; mRNA.
DR   AlphaFoldDB; Q6XJU9; -.
DR   SMR; Q6XJU9; -.
DR   STRING; 43700.ENSMALP00000026580; -.
DR   Ensembl; ENSMALT00000027048; ENSMALP00000026563; ENSMALG00000018408.
DR   OrthoDB; 1453481at2759; -.
DR   Proteomes; UP000261600; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Cytoplasm; Repeat; SH3 domain.
FT   CHAIN           1..214
FT                   /note="Osteoclast-stimulating factor 1"
FT                   /id="PRO_0000238959"
FT   DOMAIN          12..71
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REPEAT          72..101
FT                   /note="ANK 1"
FT   REPEAT          105..135
FT                   /note="ANK 2"
FT   REPEAT          139..168
FT                   /note="ANK 3"
SQ   SEQUENCE   214 AA;  23948 MW;  16537B51D269163C CRC64;
     MSKPPPKPAK PGQVKVFRAL FTFDPRTPDE LYFEEGDILY ISDTSDTNWW KGTCRGRTGL
     IPSNYVAEQA ETIDHPMHEA AKRGNLSWLR ECVENKVGIN GLDKAGNTAL YWACHGGHKD
     VVELLLNQPS VELNQQNKLG DTVLHAAAWK GYSDIVEMLL DKNARTDIRN NENKLALEMA
     TNAQCASLLK RKQGTNVTRT LSNAEEYLDD DDSD